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- W2092881964 abstract "Despite the widespread use of sulfanilamide (paraaminobenzenesulfonamide) in the treatment of certain bacterial infections, very scanty data are available concerning its toxicity for animals. Several observers have reported on its toxicity, using very limited numbers of animals. Buttle and his co-workers,<sup>1</sup>giving the drug in acacia suspension by mouth, state that 2.5 Gm. per kilogram is innocuous, 4 Gm. is tolerated but produces incoordination and paralysis, 5 Gm. kills two of six mice, and 10 Gm. kills six of six mice. Rosenthal<sup>2</sup>reports that, administered subcutaneously in olive oil suspension, 4 Gm. per kilogram killed none of five mice, while 6 Gm. per kilogram killed three of four mice. Chen<sup>3</sup>found the L. D.<sub>50</sub><sup>4</sup>for mice by intravenous injection to be from 0.35 to 0.40 Gm. per kilogram. Raiziss and his co-workers<sup>5</sup>report that 2.5 Gm. per kilogram by subcutaneous injection kills six of" @default.
- W2092881964 created "2016-06-24" @default.
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- W2092881964 date "1938-01-22" @default.
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- W2092881964 title "THE TOXICITY OF SULFANILAMIDE" @default.
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- W2092881964 doi "https://doi.org/10.1001/jama.1938.02790040006002" @default.
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