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• W2092885488 abstract "Granule cells in a dissociated neuro-glial cell culture of cerebellum when exposed to ouabain (10−3 M) for 25 min apparently swell, increase their [Ca2+]i with obvious depolarization of the mitochondrial membrane. In 3 h after ouabain was omitted from the solution, 62±3% of granule cells had pycnotic nuclei. The supplement of a solution with competitive specific antagonist of NMDA receptors, L-2-amino-7-phosphonoheptanoate (10−4 M, APH) together with ouabain prevented cells from swelling, mitochondrial deenergization, neuronal death and increase of [Ca2+]i. These data suggest that cellular Na+/K+-ATPase inactivation in neuro-glial cell cultures of cerebellum leads to glutamate (Glu) accumulation, hyperstimulation of glutamate receptors, higher Ca2+ and Na+ influxes into the cells through the channels activated by Glu. This process leads to cell swelling, mitochondrial deenergization and death of granule cells. Possibly, the decrease of Na+/K+-ATPase activity in brain cells can lead to the onset of at least some chronic neurological disorders." @default.
• W2092885488 created "2016-06-24" @default.
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• W2092885488 date "1999-07-28" @default.
• W2092885488 modified "2023-10-16" @default.
• W2092885488 title "Short-term block of Na⁺ /K⁺ -ATPase in neuro-glial cell cultures of cerebellum induces glutamate dependent damage of granule cells" @default.
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• W2092885488 doi "https://doi.org/10.1016/s0014-5793(99)00922-9" @default.
• W2092885488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10452526" @default.
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