FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092891503> ?p ?o ?g. }

• W2092891503 endingPage "560a" @default.
• W2092891503 startingPage "560a" @default.
• W2092891503 abstract "People with familial hypertrophic cardiomyopathy (FHC) harboring mutations of cardiac troponin T (cTnT) are often at a high risk of sudden cardiac death. Transgenic mice harboring some of these cTnT mutations show increased myofilament sensitivity to Ca2+ and also shortened diastolic sarcomere length (SL). Our computational studies predicted that decreasing the distances between Ca2+ release units (CRUs) of the sarcoplasmic reticulum (SR) by decreasing SL can destabilize the Ca2+ control system and increase the probability of spontaneous Ca2+ waves. Destabilization results from enhanced crosstalk between neighboring CRUs. In this study we mimic the greater myofilament Ca2+ sensitivity conferred by cTnT mutations using the myofilament Ca2+ sensitizer EMD 57033 (EMD). At concentrations up to 3 μM, EMD had no effect on either the peak Ca2+ transient or the diastolic Ca2+ levels and did not alter the SR Ca2+ load. To test the prediction that SL shortening increases the coupling between CRUs, we loaded myocytes with Di8-ANEPPS and Fluo-4 and simultaneously measured SL and Ca2+ sparks in 2 spatial dimensions using the Zeiss 5 Live high-speed 2-D scanning confocal microscope. EMD (1.5 μM) decreased SL significantly compared to the control cells in normal Tyrode (1.58 μm vs.1.69 μm, p<0.05). The spark coupling strength measures the influence of one CRU on another and is derived from an analysis of the spatio-temporal distribution of Ca2+ sparks. EMD treatment significantly increased the spark coupling strength 2.5 fold. The enhanced spark-spark coupling as diastolic SL decreases may contribute to increased frequency of spontaneous Ca2+ waves during diastole that can lead to triggered arrhythmias and sudden cardiac death in FHC." @default.
• W2092891503 created "2016-06-24" @default.
• W2092891503 creator A5034600026 @default.
• W2092891503 creator A5052084992 @default.
• W2092891503 creator A5057315986 @default.
• W2092891503 creator A5068424878 @default.
• W2092891503 creator A5072803970 @default.
• W2092891503 creator A5081924129 @default.
• W2092891503 creator A5087332380 @default.
• W2092891503 date "2011-02-01" @default.
• W2092891503 modified "2023-09-28" @default.
• W2092891503 title "Increased Myofilament Ca2+ Sensitivity Decreases Sarcomere Length and Increases Spark-Spark Interactions" @default.
• W2092891503 doi "https://doi.org/10.1016/j.bpj.2010.12.3253" @default.
• W2092891503 hasPublicationYear "2011" @default.
• W2092891503 type Work @default.
• W2092891503 sameAs 2092891503 @default.
• W2092891503 citedByCount "0" @default.
• W2092891503 crossrefType "journal-article" @default.
• W2092891503 hasAuthorship W2092891503A5034600026 @default.
• W2092891503 hasAuthorship W2092891503A5052084992 @default.
• W2092891503 hasAuthorship W2092891503A5057315986 @default.
• W2092891503 hasAuthorship W2092891503A5068424878 @default.
• W2092891503 hasAuthorship W2092891503A5072803970 @default.
• W2092891503 hasAuthorship W2092891503A5081924129 @default.
• W2092891503 hasAuthorship W2092891503A5087332380 @default.
• W2092891503 hasBestOaLocation W20928915031 @default.
• W2092891503 hasConcept C113217602 @default.
• W2092891503 hasConcept C12554922 @default.
• W2092891503 hasConcept C126322002 @default.
• W2092891503 hasConcept C131584629 @default.
• W2092891503 hasConcept C158617107 @default.
• W2092891503 hasConcept C164705383 @default.
• W2092891503 hasConcept C174054327 @default.
• W2092891503 hasConcept C185592680 @default.
• W2092891503 hasConcept C191897082 @default.
• W2092891503 hasConcept C192562407 @default.
• W2092891503 hasConcept C207200792 @default.
• W2092891503 hasConcept C2778996579 @default.
• W2092891503 hasConcept C2780185194 @default.
• W2092891503 hasConcept C36036425 @default.
• W2092891503 hasConcept C500558357 @default.
• W2092891503 hasConcept C55493867 @default.
• W2092891503 hasConcept C57900726 @default.
• W2092891503 hasConcept C68731436 @default.
• W2092891503 hasConcept C71924100 @default.
• W2092891503 hasConcept C84393581 @default.
• W2092891503 hasConcept C86803240 @default.
• W2092891503 hasConcept C8880881 @default.
• W2092891503 hasConceptScore W2092891503C113217602 @default.
• W2092891503 hasConceptScore W2092891503C12554922 @default.
• W2092891503 hasConceptScore W2092891503C126322002 @default.
• W2092891503 hasConceptScore W2092891503C131584629 @default.
• W2092891503 hasConceptScore W2092891503C158617107 @default.
• W2092891503 hasConceptScore W2092891503C164705383 @default.
• W2092891503 hasConceptScore W2092891503C174054327 @default.
• W2092891503 hasConceptScore W2092891503C185592680 @default.
• W2092891503 hasConceptScore W2092891503C191897082 @default.
• W2092891503 hasConceptScore W2092891503C192562407 @default.
• W2092891503 hasConceptScore W2092891503C207200792 @default.
• W2092891503 hasConceptScore W2092891503C2778996579 @default.
• W2092891503 hasConceptScore W2092891503C2780185194 @default.
• W2092891503 hasConceptScore W2092891503C36036425 @default.
• W2092891503 hasConceptScore W2092891503C500558357 @default.
• W2092891503 hasConceptScore W2092891503C55493867 @default.
• W2092891503 hasConceptScore W2092891503C57900726 @default.
• W2092891503 hasConceptScore W2092891503C68731436 @default.
• W2092891503 hasConceptScore W2092891503C71924100 @default.
• W2092891503 hasConceptScore W2092891503C84393581 @default.
• W2092891503 hasConceptScore W2092891503C86803240 @default.
• W2092891503 hasConceptScore W2092891503C8880881 @default.
• W2092891503 hasIssue "3" @default.
• W2092891503 hasLocation W20928915031 @default.
• W2092891503 hasOpenAccess W2092891503 @default.
• W2092891503 hasPrimaryLocation W20928915031 @default.
• W2092891503 hasRelatedWork W154966463 @default.
• W2092891503 hasRelatedWork W1968719617 @default.
• W2092891503 hasRelatedWork W1973503604 @default.
• W2092891503 hasRelatedWork W1985950460 @default.
• W2092891503 hasRelatedWork W2006927352 @default.
• W2092891503 hasRelatedWork W2019001590 @default.
• W2092891503 hasRelatedWork W2047389461 @default.
• W2092891503 hasRelatedWork W2060561208 @default.
• W2092891503 hasRelatedWork W2070861639 @default.
• W2092891503 hasRelatedWork W2110874154 @default.
• W2092891503 hasRelatedWork W2120327065 @default.
• W2092891503 hasRelatedWork W2169669126 @default.
• W2092891503 hasRelatedWork W2309341672 @default.
• W2092891503 hasRelatedWork W2916047454 @default.
• W2092891503 hasRelatedWork W2969195416 @default.
• W2092891503 hasRelatedWork W3017381305 @default.
• W2092891503 hasRelatedWork W3031351869 @default.
• W2092891503 hasRelatedWork W610087458 @default.
• W2092891503 hasRelatedWork W190913293 @default.
• W2092891503 hasRelatedWork W2558408392 @default.
• W2092891503 hasVolume "100" @default.
• W2092891503 isParatext "false" @default.
• W2092891503 isRetracted "false" @default.
• W2092891503 magId "2092891503" @default.

• next