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- W2092893116 abstract "Abstract Replication of herpes simplex virus (HSV) in HeLa cells is completely restricted if the cells are superinfected with poliovirus within 5 hr after HSV infection. Poliovirus replicates normally in these dually infected cells unless HSV is given substantial time and multiplicity advantages. Translation, but not replication, of the poliovirus genome appears to be required for the restriction of HSV. DNA and RNA synthesis in HSV-infected cells is not significantly altered after poliovirus superinfection, but HSV directed protein synthesis is completely inhibited, and polyribosomes carrying HSV mRNA are disaggregated within 3 hr after superinfection. These results suggest that the restriction of HSV replication by poliovirus is due to a selective inhibition of HSV mRNA translation." @default.
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- W2092893116 date "1972-04-01" @default.
- W2092893116 modified "2023-09-25" @default.
- W2092893116 title "Restriction of herpes simplex virus replication by poliovirus: A selective inhibition of viral translation" @default.
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- W2092893116 doi "https://doi.org/10.1016/0042-6822(72)90128-6" @default.
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