FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092893243> ?p ?o ?g. }

• W2092893243 endingPage "6431" @default.
• W2092893243 startingPage "6421" @default.
• W2092893243 abstract "How the brain maintains long-term memories is one of the major outstanding questions in modern neuroscience. Evidence from mammalian studies indicates that activity of a protein kinase C (PKC) isoform, protein kinase Mζ (PKMζ), plays a critical role in the maintenance of long-term memory. But the range of memories whose persistence depends on PKMζ, and the mechanisms that underlie the effect of PKMζ on long-term memory, remain obscure. Recently, a PKM isoform, known as PKM Apl III, was cloned from the nervous system of Aplysia . Here, we tested whether PKM Apl III plays a critical role in long-term memory maintenance in Aplysia . Intrahemocoel injections of the pseudosubstrate inhibitory peptide ZIP (ζ inhibitory peptide) or the PKC inhibitor chelerythrine erased the memory for long-term sensitization (LTS) of the siphon-withdrawal reflex (SWR) as late as 7 d after training. In addition, both PKM inhibitors disrupted the maintenance of long-term (≥24 h) facilitation (LTF) of the sensorimotor synapse, a form of synaptic plasticity previously shown to mediate LTS of the SWR. Together with previous results (Bougie et al., 2009), our results support the idea that long-term memory in Aplysia is maintained via a positive-feedback loop involving PKM Apl III-dependent protein phosphorylation. The present data extend the known role of PKM in memory maintenance to a simple and well studied type of long-term learning. Furthermore, the demonstration that PKM activity underlies the persistence of LTF of the Aplysia sensorimotor synapse, a form of synaptic plasticity amenable to rigorous cellular and molecular analyses, should facilitate efforts to understand how PKM activity maintains memory." @default.
• W2092893243 created "2016-06-24" @default.
• W2092893243 creator A5002505495 @default.
• W2092893243 creator A5009878797 @default.
• W2092893243 creator A5069700720 @default.
• W2092893243 creator A5087488298 @default.
• W2092893243 date "2011-04-27" @default.
• W2092893243 modified "2023-10-15" @default.
• W2092893243 title "Protein Kinase M Maintains Long-Term Sensitization and Long-Term Facilitation in<i>Aplysia</i>" @default.
• W2092893243 cites W1536186648 @default.
• W2092893243 cites W1605215937 @default.
• W2092893243 cites W1608785134 @default.
• W2092893243 cites W1815483998 @default.
• W2092893243 cites W1884538784 @default.
• W2092893243 cites W1963628765 @default.
• W2092893243 cites W1967296575 @default.
• W2092893243 cites W1972155455 @default.
• W2092893243 cites W1972434093 @default.
• W2092893243 cites W1974491267 @default.
• W2092893243 cites W1979055157 @default.
• W2092893243 cites W1984260356 @default.
• W2092893243 cites W1985927272 @default.
• W2092893243 cites W2002140212 @default.
• W2092893243 cites W2006758327 @default.
• W2092893243 cites W2008588148 @default.
• W2092893243 cites W2011137853 @default.
• W2092893243 cites W2011420167 @default.
• W2092893243 cites W2011567013 @default.
• W2092893243 cites W2015966635 @default.
• W2092893243 cites W2018187135 @default.
• W2092893243 cites W2026757366 @default.
• W2092893243 cites W2029252387 @default.
• W2092893243 cites W2031104034 @default.
• W2092893243 cites W2032408452 @default.
• W2092893243 cites W2032469042 @default.
• W2092893243 cites W2039329450 @default.
• W2092893243 cites W2041037918 @default.
• W2092893243 cites W2042193675 @default.
• W2092893243 cites W2042402461 @default.
• W2092893243 cites W2044126921 @default.
• W2092893243 cites W2046656964 @default.
• W2092893243 cites W2049541916 @default.
• W2092893243 cites W2058283162 @default.
• W2092893243 cites W2058851330 @default.
• W2092893243 cites W2059117412 @default.
• W2092893243 cites W2072699152 @default.
• W2092893243 cites W2073338028 @default.
• W2092893243 cites W2074873108 @default.
• W2092893243 cites W2080480553 @default.
• W2092893243 cites W2086238626 @default.
• W2092893243 cites W2090985642 @default.
• W2092893243 cites W2091114379 @default.
• W2092893243 cites W2091845852 @default.
• W2092893243 cites W2092112738 @default.
• W2092893243 cites W2098354755 @default.
• W2092893243 cites W2098743881 @default.
• W2092893243 cites W2099036181 @default.
• W2092893243 cites W2103625610 @default.
• W2092893243 cites W2104643304 @default.
• W2092893243 cites W2129972982 @default.
• W2092893243 cites W2135039550 @default.
• W2092893243 cites W2136813339 @default.
• W2092893243 cites W2154806346 @default.
• W2092893243 cites W2169399769 @default.
• W2092893243 cites W2784028944 @default.
• W2092893243 cites W4213256327 @default.
• W2092893243 cites W4319292992 @default.
• W2092893243 doi "https://doi.org/10.1523/jneurosci.4744-10.2011" @default.
• W2092893243 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3102530" @default.
• W2092893243 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21525283" @default.
• W2092893243 hasPublicationYear "2011" @default.
• W2092893243 type Work @default.
• W2092893243 sameAs 2092893243 @default.
• W2092893243 citedByCount "120" @default.
• W2092893243 countsByYear W20928932432012 @default.
• W2092893243 countsByYear W20928932432013 @default.
• W2092893243 countsByYear W20928932432014 @default.
• W2092893243 countsByYear W20928932432015 @default.
• W2092893243 countsByYear W20928932432016 @default.
• W2092893243 countsByYear W20928932432017 @default.
• W2092893243 countsByYear W20928932432018 @default.
• W2092893243 countsByYear W20928932432019 @default.
• W2092893243 countsByYear W20928932432020 @default.
• W2092893243 countsByYear W20928932432021 @default.
• W2092893243 countsByYear W20928932432022 @default.
• W2092893243 countsByYear W20928932432023 @default.
• W2092893243 crossrefType "journal-article" @default.
• W2092893243 hasAuthorship W2092893243A5002505495 @default.
• W2092893243 hasAuthorship W2092893243A5009878797 @default.
• W2092893243 hasAuthorship W2092893243A5069700720 @default.
• W2092893243 hasAuthorship W2092893243A5087488298 @default.
• W2092893243 hasBestOaLocation W20928932431 @default.
• W2092893243 hasConcept C112592302 @default.
• W2092893243 hasConcept C11960822 @default.
• W2092893243 hasConcept C125667969 @default.
• W2092893243 hasConcept C127445978 @default.
• W2092893243 hasConcept C150720761 @default.
• W2092893243 hasConcept C169760540 @default.

• next