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- W2092912497 abstract "During the course of this study, the luteolytic properties of estradiol-17β injected intramuscularly at midcycle (days 11 and 12), progesterone injected intramuscularly early in the cycle (days 0 through 5), and prostaglandin F2α intrauterine infused on day 8 of cycle were tested by using endometrium-intact and endometrium-modified ewes to elucidate further the mechanisms involved. The results of this experiment suggested the following: (a) the luteolytic action of estradiol-17β administered at mid-cycle is mediated directly through the endometrium, possibly by causing synthesis or release of the uterine luteolytic agent by the endometrium; (b) the luteolytic action of progesterone administered early in the cycle is mediated partially through the endometrium (uterine-gonadal axis) and partially through the hypothalamo-hypophyseal-gonadal axis; (c) the intrauterine infusion of PGF2α in endometrium-modified ewes results in luteolysis, demonstrating that PGF2α is an endometrial luteolytic agent." @default.
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- W2092912497 date "1977-05-01" @default.
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- W2092912497 title "The effects of estradiol-17β, progesterone, and PGF2α-tham on corpora lutea in ewes with intact and partially destroyed endometrium" @default.
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- W2092912497 doi "https://doi.org/10.1016/0093-691x(77)90258-8" @default.
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