FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092914497> ?p ?o ?g. }

• W2092914497 endingPage "756" @default.
• W2092914497 startingPage "745" @default.
• W2092914497 abstract "Pituitary adenylate cyclase activating polypeptide has been shown to reduce apoptosis in neonatal cerebellar and olfactory receptor neurons, however the underlying mechanisms have not been elucidated. In addition, the neuroprotective effects of pituitary adenylate cyclase activating polypeptide have not been examined in adult tissues. To study the effects of pituitary adenylate cyclase activating polypeptide on neurons in apoptosis, we measured caspase activation in adult olfactory receptor neurons in vitro. Interestingly, we found that the protective effects of pituitary adenylate cyclase activating polypeptide were related to the absence of a 4-aminopyridine (IC50=144 microM) sensitive rapidly inactivating potassium current often referred to as A-type current. In the presence of 40 nM pituitary adenylate cyclase activating polypeptide 38, both A-type current and activated caspases were significantly reduced. A-type current reduction by pituitary adenylate cyclase activating polypeptide was blocked by inhibiting the phospholipase C pathway, but not the adenylyl cyclase pathway. Our observation that 5 mM 4-aminopyridine mimicked the caspase inhibiting effects of pituitary adenylate cyclase activating polypeptide indicates that A-type current is involved in apoptosis. This work contributes to our growing understanding that potassium currents are involved with the activation of caspases to affect the balance between cell life and death." @default.
• W2092914497 created "2016-06-24" @default.
• W2092914497 creator A5017850162 @default.
• W2092914497 creator A5091510617 @default.
• W2092914497 date "2005-01-01" @default.
• W2092914497 modified "2023-10-14" @default.
• W2092914497 title "Pituitary adenylate cyclase activating polypeptide reduces A-type K+ currents and caspase activity in cultured adult mouse olfactory neurons" @default.
• W2092914497 cites W1604818604 @default.
• W2092914497 cites W1628568274 @default.
• W2092914497 cites W1748251373 @default.
• W2092914497 cites W1886438078 @default.
• W2092914497 cites W1912063668 @default.
• W2092914497 cites W1965397665 @default.
• W2092914497 cites W1966707756 @default.
• W2092914497 cites W1966936548 @default.
• W2092914497 cites W1978177808 @default.
• W2092914497 cites W1979067492 @default.
• W2092914497 cites W1986245882 @default.
• W2092914497 cites W1991105592 @default.
• W2092914497 cites W1991399785 @default.
• W2092914497 cites W2000493501 @default.
• W2092914497 cites W2001343658 @default.
• W2092914497 cites W2002171978 @default.
• W2092914497 cites W2013920501 @default.
• W2092914497 cites W2016111983 @default.
• W2092914497 cites W2016654953 @default.
• W2092914497 cites W2022199851 @default.
• W2092914497 cites W2022347049 @default.
• W2092914497 cites W2024987339 @default.
• W2092914497 cites W2026441283 @default.
• W2092914497 cites W2046623769 @default.
• W2092914497 cites W2050648377 @default.
• W2092914497 cites W2062808881 @default.
• W2092914497 cites W2063959893 @default.
• W2092914497 cites W2064364835 @default.
• W2092914497 cites W2065026573 @default.
• W2092914497 cites W2065069478 @default.
• W2092914497 cites W2070908828 @default.
• W2092914497 cites W2075482214 @default.
• W2092914497 cites W2078943269 @default.
• W2092914497 cites W2097482307 @default.
• W2092914497 cites W2098565560 @default.
• W2092914497 cites W2107100596 @default.
• W2092914497 cites W2107922680 @default.
• W2092914497 cites W2117044211 @default.
• W2092914497 cites W2117354575 @default.
• W2092914497 cites W2122160136 @default.
• W2092914497 cites W2126744615 @default.
• W2092914497 cites W2138698041 @default.
• W2092914497 cites W2142766154 @default.
• W2092914497 cites W2147074244 @default.
• W2092914497 cites W2151875422 @default.
• W2092914497 cites W2158382367 @default.
• W2092914497 cites W2160154880 @default.
• W2092914497 cites W2188714410 @default.
• W2092914497 cites W2335873000 @default.
• W2092914497 cites W2387856814 @default.
• W2092914497 cites W2410678179 @default.
• W2092914497 doi "https://doi.org/10.1016/j.neuroscience.2005.05.007" @default.
• W2092914497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16019148" @default.
• W2092914497 hasPublicationYear "2005" @default.
• W2092914497 type Work @default.
• W2092914497 sameAs 2092914497 @default.
• W2092914497 citedByCount "28" @default.
• W2092914497 countsByYear W20929144972012 @default.
• W2092914497 countsByYear W20929144972013 @default.
• W2092914497 countsByYear W20929144972014 @default.
• W2092914497 countsByYear W20929144972015 @default.
• W2092914497 countsByYear W20929144972016 @default.
• W2092914497 crossrefType "journal-article" @default.
• W2092914497 hasAuthorship W2092914497A5017850162 @default.
• W2092914497 hasAuthorship W2092914497A5091510617 @default.
• W2092914497 hasConcept C118303440 @default.
• W2092914497 hasConcept C126322002 @default.
• W2092914497 hasConcept C134018914 @default.
• W2092914497 hasConcept C170493617 @default.
• W2092914497 hasConcept C180526460 @default.
• W2092914497 hasConcept C185592680 @default.
• W2092914497 hasConcept C2779178603 @default.
• W2092914497 hasConcept C2779496938 @default.
• W2092914497 hasConcept C2779980732 @default.
• W2092914497 hasConcept C2780069284 @default.
• W2092914497 hasConcept C55493867 @default.
• W2092914497 hasConcept C71924100 @default.
• W2092914497 hasConcept C8330315 @default.
• W2092914497 hasConcept C86803240 @default.
• W2092914497 hasConcept C95444343 @default.
• W2092914497 hasConceptScore W2092914497C118303440 @default.
• W2092914497 hasConceptScore W2092914497C126322002 @default.
• W2092914497 hasConceptScore W2092914497C134018914 @default.
• W2092914497 hasConceptScore W2092914497C170493617 @default.
• W2092914497 hasConceptScore W2092914497C180526460 @default.
• W2092914497 hasConceptScore W2092914497C185592680 @default.
• W2092914497 hasConceptScore W2092914497C2779178603 @default.
• W2092914497 hasConceptScore W2092914497C2779496938 @default.
• W2092914497 hasConceptScore W2092914497C2779980732 @default.
• W2092914497 hasConceptScore W2092914497C2780069284 @default.
• W2092914497 hasConceptScore W2092914497C55493867 @default.

• next