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• W2092920274 abstract "ObjectiveRole of mid-luteal hormonal profile in predicting early pregnancy in patients undergoing IVF/ICSI is investigated. Clinical outcome and hormone profile of the pregnant and non-pregnant women were analyzed.DesignProspective analysis.Materials and methodsThis study was conducted at the Institute of Reproductive Medicine, Salt Lake, Kolkata, India. Approval from the Institutional Ethics Committee was obtained. 270 women (25–42 years) undergoing IVF/ICSI treatment with appropriate endometrial thickness on the day of ET were included. Women with poor ovarian reserve, advanced endometriosis and PCOS were excluded. All patients received mid luteal long protocol down regulation with GnRH-a and recombinant FSH followed by serial folliculometry from d6 of stimulation. Oocytes were retrieved 34–36 hrs following hCG injection and subjected to conventional IVF/ICSI. Day 2 ET was performed and luteal support with micronized progesterone was initiated on the day of ET. Serum E2, P and FSH levels were evaluated on d0, d7 and d14. Luteal support was continued till 12th week when serum βhCG was positive. Data were analyzed using Student's t test, where appropriate.ResultsOut of 270 women, 114 were found pregnant (Group A) while 156 did not conceive (Group B). In 48% of Gr A patients, E2 level was found to decline d0 onwards. However, in the same group (Gr A) remaining 52% exhibited rising E2 level. Interestingly, 76% of Gr B women had gradual decline in their E2 level while remaining 24% showed either no change or only marginal rise d0 onwards. The mean P level on d7 declined significantly in both the groups as compared to d0 but subsequently increased through d14. The initial reduction was observed to be more significant in Gr B as compared to Gr A (P<0.05). However, the subsequent rise in the P level d7 onwards was more significant in Gr A as compared to Gr B (P<0.006). The mean FSH levels declined in both groups from d0 to d7. The decrease was highly significant in Gr A as compared to Gr B (P<0.0002). While FSH level continued to decrease beyond d7 in Gr A, FSH level was found to be considerably high on d14 in Gr B patients.ConclusionsOur results indicate that a declining FSH level can be a useful indicator of successful implantation in IVF/ICSI patients. Decreasing estradiol level (E2), on the other hand, may be correlated with negative pregnancy outcome. Initial suppression followed by elevated progesterone levels indicate endogenous luteal rescue. ObjectiveRole of mid-luteal hormonal profile in predicting early pregnancy in patients undergoing IVF/ICSI is investigated. Clinical outcome and hormone profile of the pregnant and non-pregnant women were analyzed. Role of mid-luteal hormonal profile in predicting early pregnancy in patients undergoing IVF/ICSI is investigated. Clinical outcome and hormone profile of the pregnant and non-pregnant women were analyzed. DesignProspective analysis. Prospective analysis. Materials and methodsThis study was conducted at the Institute of Reproductive Medicine, Salt Lake, Kolkata, India. Approval from the Institutional Ethics Committee was obtained. 270 women (25–42 years) undergoing IVF/ICSI treatment with appropriate endometrial thickness on the day of ET were included. Women with poor ovarian reserve, advanced endometriosis and PCOS were excluded. All patients received mid luteal long protocol down regulation with GnRH-a and recombinant FSH followed by serial folliculometry from d6 of stimulation. Oocytes were retrieved 34–36 hrs following hCG injection and subjected to conventional IVF/ICSI. Day 2 ET was performed and luteal support with micronized progesterone was initiated on the day of ET. Serum E2, P and FSH levels were evaluated on d0, d7 and d14. Luteal support was continued till 12th week when serum βhCG was positive. Data were analyzed using Student's t test, where appropriate. This study was conducted at the Institute of Reproductive Medicine, Salt Lake, Kolkata, India. Approval from the Institutional Ethics Committee was obtained. 270 women (25–42 years) undergoing IVF/ICSI treatment with appropriate endometrial thickness on the day of ET were included. Women with poor ovarian reserve, advanced endometriosis and PCOS were excluded. All patients received mid luteal long protocol down regulation with GnRH-a and recombinant FSH followed by serial folliculometry from d6 of stimulation. Oocytes were retrieved 34–36 hrs following hCG injection and subjected to conventional IVF/ICSI. Day 2 ET was performed and luteal support with micronized progesterone was initiated on the day of ET. Serum E2, P and FSH levels were evaluated on d0, d7 and d14. Luteal support was continued till 12th week when serum βhCG was positive. Data were analyzed using Student's t test, where appropriate. ResultsOut of 270 women, 114 were found pregnant (Group A) while 156 did not conceive (Group B). In 48% of Gr A patients, E2 level was found to decline d0 onwards. However, in the same group (Gr A) remaining 52% exhibited rising E2 level. Interestingly, 76% of Gr B women had gradual decline in their E2 level while remaining 24% showed either no change or only marginal rise d0 onwards. The mean P level on d7 declined significantly in both the groups as compared to d0 but subsequently increased through d14. The initial reduction was observed to be more significant in Gr B as compared to Gr A (P<0.05). However, the subsequent rise in the P level d7 onwards was more significant in Gr A as compared to Gr B (P<0.006). The mean FSH levels declined in both groups from d0 to d7. The decrease was highly significant in Gr A as compared to Gr B (P<0.0002). While FSH level continued to decrease beyond d7 in Gr A, FSH level was found to be considerably high on d14 in Gr B patients. Out of 270 women, 114 were found pregnant (Group A) while 156 did not conceive (Group B). In 48% of Gr A patients, E2 level was found to decline d0 onwards. However, in the same group (Gr A) remaining 52% exhibited rising E2 level. Interestingly, 76% of Gr B women had gradual decline in their E2 level while remaining 24% showed either no change or only marginal rise d0 onwards. The mean P level on d7 declined significantly in both the groups as compared to d0 but subsequently increased through d14. The initial reduction was observed to be more significant in Gr B as compared to Gr A (P<0.05). However, the subsequent rise in the P level d7 onwards was more significant in Gr A as compared to Gr B (P<0.006). The mean FSH levels declined in both groups from d0 to d7. The decrease was highly significant in Gr A as compared to Gr B (P<0.0002). While FSH level continued to decrease beyond d7 in Gr A, FSH level was found to be considerably high on d14 in Gr B patients. ConclusionsOur results indicate that a declining FSH level can be a useful indicator of successful implantation in IVF/ICSI patients. Decreasing estradiol level (E2), on the other hand, may be correlated with negative pregnancy outcome. Initial suppression followed by elevated progesterone levels indicate endogenous luteal rescue. Our results indicate that a declining FSH level can be a useful indicator of successful implantation in IVF/ICSI patients. Decreasing estradiol level (E2), on the other hand, may be correlated with negative pregnancy outcome. Initial suppression followed by elevated progesterone levels indicate endogenous luteal rescue." @default.
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• W2092920274 date "2007-09-01" @default.
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• W2092920274 title "Luteal phase serum follicle stimulating hormone and estradiol levels early predictive markers of pregnancy outcome" @default.
• W2092920274 doi "https://doi.org/10.1016/j.fertnstert.2007.07.572" @default.
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