Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092931526> ?p ?o ?g. }
- W2092931526 endingPage "2575" @default.
- W2092931526 startingPage "2565" @default.
- W2092931526 abstract "A Werner syndrome protein homolog in C. elegans (WRN-1) was immunolocalized to the nuclei of germ cells, embryonic cells, and many other cells of larval and adult worms. When wrn-1 expression was inhibited by RNA interference (RNAi), a slight reduction in C. elegans life span was observed, with accompanying signs of premature aging, such as earlier accumulation of lipofuscin and tissue deterioration in the head. In addition,various developmental defects, including small, dumpy, ruptured, transparent body, growth arrest and bag of worms, were induced by RNAi. The frequency of these defects was accentuated by γ-irradiation, implying that they were derived from spontaneous or induced DNA damage. wrn-1(RNAi) worms showed accelerated larval growth irrespective of γ-irradiation, and pre-meiotic germ cells had an abnormal checkpoint response to DNA replication blockage. These observations suggest that WRN-1 acts as a checkpoint protein for DNA damage and replication blockage. This idea is also supported by an accelerated S phase in wrn-1(RNAi) embryonic cells. wrn-1(RNAi) phenotypes similar to those of Werner syndrome, such as premature aging and short stature, suggest wrn-1-deficient C. elegans as a useful model organism for Werner syndrome." @default.
- W2092931526 created "2016-06-24" @default.
- W2092931526 creator A5002829719 @default.
- W2092931526 creator A5013668594 @default.
- W2092931526 creator A5024403087 @default.
- W2092931526 creator A5071662001 @default.
- W2092931526 date "2004-06-01" @default.
- W2092931526 modified "2023-10-03" @default.
- W2092931526 title "A Werner syndrome protein homolog affects<i>C. elegans</i>development, growth rate, life span and sensitivity to DNA damage by acting at a DNA damage checkpoint" @default.
- W2092931526 cites W108104126 @default.
- W2092931526 cites W1486450190 @default.
- W2092931526 cites W1487697828 @default.
- W2092931526 cites W1538603370 @default.
- W2092931526 cites W1966347623 @default.
- W2092931526 cites W1969578702 @default.
- W2092931526 cites W1970285696 @default.
- W2092931526 cites W1975817860 @default.
- W2092931526 cites W1976194927 @default.
- W2092931526 cites W1976634184 @default.
- W2092931526 cites W1987614699 @default.
- W2092931526 cites W1998617902 @default.
- W2092931526 cites W2004963755 @default.
- W2092931526 cites W2015133519 @default.
- W2092931526 cites W2016141642 @default.
- W2092931526 cites W2020454013 @default.
- W2092931526 cites W2022166341 @default.
- W2092931526 cites W2025350653 @default.
- W2092931526 cites W2025997331 @default.
- W2092931526 cites W2026766143 @default.
- W2092931526 cites W2032188321 @default.
- W2092931526 cites W2033227353 @default.
- W2092931526 cites W2033676950 @default.
- W2092931526 cites W2033985470 @default.
- W2092931526 cites W2035174191 @default.
- W2092931526 cites W2050496120 @default.
- W2092931526 cites W2058094663 @default.
- W2092931526 cites W2064310741 @default.
- W2092931526 cites W2066253067 @default.
- W2092931526 cites W2071924188 @default.
- W2092931526 cites W2079060327 @default.
- W2092931526 cites W2089041372 @default.
- W2092931526 cites W2089827948 @default.
- W2092931526 cites W2091170248 @default.
- W2092931526 cites W2095762376 @default.
- W2092931526 cites W2110522968 @default.
- W2092931526 cites W2129849137 @default.
- W2092931526 cites W2135501527 @default.
- W2092931526 cites W2138466316 @default.
- W2092931526 cites W2142517373 @default.
- W2092931526 cites W2147019339 @default.
- W2092931526 cites W2151034892 @default.
- W2092931526 cites W2152472623 @default.
- W2092931526 cites W2159310233 @default.
- W2092931526 cites W2161431287 @default.
- W2092931526 cites W2312706942 @default.
- W2092931526 cites W2330395802 @default.
- W2092931526 doi "https://doi.org/10.1242/dev.01136" @default.
- W2092931526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15115755" @default.
- W2092931526 hasPublicationYear "2004" @default.
- W2092931526 type Work @default.
- W2092931526 sameAs 2092931526 @default.
- W2092931526 citedByCount "51" @default.
- W2092931526 countsByYear W20929315262012 @default.
- W2092931526 countsByYear W20929315262013 @default.
- W2092931526 countsByYear W20929315262014 @default.
- W2092931526 countsByYear W20929315262015 @default.
- W2092931526 countsByYear W20929315262016 @default.
- W2092931526 countsByYear W20929315262017 @default.
- W2092931526 countsByYear W20929315262018 @default.
- W2092931526 countsByYear W20929315262019 @default.
- W2092931526 countsByYear W20929315262020 @default.
- W2092931526 countsByYear W20929315262021 @default.
- W2092931526 countsByYear W20929315262022 @default.
- W2092931526 countsByYear W20929315262023 @default.
- W2092931526 crossrefType "journal-article" @default.
- W2092931526 hasAuthorship W2092931526A5002829719 @default.
- W2092931526 hasAuthorship W2092931526A5013668594 @default.
- W2092931526 hasAuthorship W2092931526A5024403087 @default.
- W2092931526 hasAuthorship W2092931526A5071662001 @default.
- W2092931526 hasConcept C104317684 @default.
- W2092931526 hasConcept C105696609 @default.
- W2092931526 hasConcept C134935766 @default.
- W2092931526 hasConcept C143425029 @default.
- W2092931526 hasConcept C153911025 @default.
- W2092931526 hasConcept C161223559 @default.
- W2092931526 hasConcept C166703698 @default.
- W2092931526 hasConcept C2778090637 @default.
- W2092931526 hasConcept C2778944004 @default.
- W2092931526 hasConcept C2909947164 @default.
- W2092931526 hasConcept C29537977 @default.
- W2092931526 hasConcept C54086632 @default.
- W2092931526 hasConcept C54355233 @default.
- W2092931526 hasConcept C552990157 @default.
- W2092931526 hasConcept C67705224 @default.
- W2092931526 hasConcept C73573662 @default.
- W2092931526 hasConcept C86803240 @default.
- W2092931526 hasConcept C95444343 @default.
- W2092931526 hasConceptScore W2092931526C104317684 @default.