FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092937557> ?p ?o ?g. }

• W2092937557 endingPage "6278" @default.
• W2092937557 startingPage "6272" @default.
• W2092937557 abstract "The modification of homeodomain‐interacting protein kinase 2 (HIPK2) by small ubiquitin‐like modifier 1 (SUMO‐1) plays an important role in its targeting into the promyelocytic leukemia body, as well as in its differential interaction with binding partner, but the desumoylation of HIPK2 by SUMO‐specific proteases is largely unknown. In this study, we show that HIPK2 is a desumoylation target for the SUMO‐specific protease SENP1 that shuttles between the cytoplasm and the nucleus. Mutation analyses reveal that SENP1 contains the nuclear export sequence (NES) within the extreme carboxyl‐terminal region, and SENP1 is exported to the cytoplasm in a NES‐dependent manner. Sumoylated HIPK2 are deconjugated by SENP1 both in vitro and in cultured cells, and the desumoylation is enhanced either by the forced translocation of SENP1 into the nucleus or by the SENP1 NES mutant. Concomitantly, desumoylation induces dissociation of HIPK2 from nuclear bodies. These results demonstrate that HIPK2 is a target for SENP1 desumoylation, and suggest that the desumoylation of HIPK2 may be regulated by the cytoplasmic‐nuclear shuttling of SENP1." @default.
• W2092937557 created "2016-06-24" @default.
• W2092937557 creator A5007409800 @default.
• W2092937557 creator A5011861620 @default.
• W2092937557 creator A5018527317 @default.
• W2092937557 creator A5028840514 @default.
• W2092937557 creator A5028894700 @default.
• W2092937557 creator A5090387178 @default.
• W2092937557 date "2005-10-19" @default.
• W2092937557 modified "2023-10-13" @default.
• W2092937557 title "Desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) through the cytoplasmic-nuclear shuttling of the SUMO-specific protease SENP1" @default.
• W2092937557 cites W1619212443 @default.
• W2092937557 cites W1666755687 @default.
• W2092937557 cites W1965493433 @default.
• W2092937557 cites W1965856748 @default.
• W2092937557 cites W1974051152 @default.
• W2092937557 cites W1984405912 @default.
• W2092937557 cites W1987556650 @default.
• W2092937557 cites W1994432533 @default.
• W2092937557 cites W2037845650 @default.
• W2092937557 cites W2042389934 @default.
• W2092937557 cites W2042862271 @default.
• W2092937557 cites W2048376155 @default.
• W2092937557 cites W2054311839 @default.
• W2092937557 cites W2054826455 @default.
• W2092937557 cites W2057906302 @default.
• W2092937557 cites W2061630866 @default.
• W2092937557 cites W2062413542 @default.
• W2092937557 cites W2062600056 @default.
• W2092937557 cites W2063822655 @default.
• W2092937557 cites W2065309690 @default.
• W2092937557 cites W2072339454 @default.
• W2092937557 cites W2074582828 @default.
• W2092937557 cites W2074760482 @default.
• W2092937557 cites W2081446916 @default.
• W2092937557 cites W2083954549 @default.
• W2092937557 cites W2103724039 @default.
• W2092937557 cites W2110643873 @default.
• W2092937557 cites W2111072547 @default.
• W2092937557 cites W2112441454 @default.
• W2092937557 cites W2118121244 @default.
• W2092937557 cites W2118177072 @default.
• W2092937557 cites W2123256728 @default.
• W2092937557 cites W2134166432 @default.
• W2092937557 cites W2147656349 @default.
• W2092937557 cites W95252060 @default.
• W2092937557 doi "https://doi.org/10.1016/j.febslet.2005.10.010" @default.
• W2092937557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16253240" @default.
• W2092937557 hasPublicationYear "2005" @default.
• W2092937557 type Work @default.
• W2092937557 sameAs 2092937557 @default.
• W2092937557 citedByCount "43" @default.
• W2092937557 countsByYear W20929375572012 @default.
• W2092937557 countsByYear W20929375572013 @default.
• W2092937557 countsByYear W20929375572014 @default.
• W2092937557 countsByYear W20929375572017 @default.
• W2092937557 countsByYear W20929375572019 @default.
• W2092937557 countsByYear W20929375572020 @default.
• W2092937557 countsByYear W20929375572021 @default.
• W2092937557 countsByYear W20929375572022 @default.
• W2092937557 countsByYear W20929375572023 @default.
• W2092937557 crossrefType "journal-article" @default.
• W2092937557 hasAuthorship W2092937557A5007409800 @default.
• W2092937557 hasAuthorship W2092937557A5011861620 @default.
• W2092937557 hasAuthorship W2092937557A5018527317 @default.
• W2092937557 hasAuthorship W2092937557A5028840514 @default.
• W2092937557 hasAuthorship W2092937557A5028894700 @default.
• W2092937557 hasAuthorship W2092937557A5090387178 @default.
• W2092937557 hasConcept C104317684 @default.
• W2092937557 hasConcept C143065580 @default.
• W2092937557 hasConcept C153911025 @default.
• W2092937557 hasConcept C171350616 @default.
• W2092937557 hasConcept C181199279 @default.
• W2092937557 hasConcept C190062978 @default.
• W2092937557 hasConcept C25602115 @default.
• W2092937557 hasConcept C2776714187 @default.
• W2092937557 hasConcept C2780114586 @default.
• W2092937557 hasConcept C54757728 @default.
• W2092937557 hasConcept C55493867 @default.
• W2092937557 hasConcept C86803240 @default.
• W2092937557 hasConcept C95444343 @default.
• W2092937557 hasConceptScore W2092937557C104317684 @default.
• W2092937557 hasConceptScore W2092937557C143065580 @default.
• W2092937557 hasConceptScore W2092937557C153911025 @default.
• W2092937557 hasConceptScore W2092937557C171350616 @default.
• W2092937557 hasConceptScore W2092937557C181199279 @default.
• W2092937557 hasConceptScore W2092937557C190062978 @default.
• W2092937557 hasConceptScore W2092937557C25602115 @default.
• W2092937557 hasConceptScore W2092937557C2776714187 @default.
• W2092937557 hasConceptScore W2092937557C2780114586 @default.
• W2092937557 hasConceptScore W2092937557C54757728 @default.
• W2092937557 hasConceptScore W2092937557C55493867 @default.
• W2092937557 hasConceptScore W2092937557C86803240 @default.
• W2092937557 hasConceptScore W2092937557C95444343 @default.
• W2092937557 hasIssue "27" @default.
• W2092937557 hasLocation W20929375571 @default.
• W2092937557 hasLocation W20929375572 @default.
• W2092937557 hasOpenAccess W2092937557 @default.

• next