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- W2092942673 endingPage "218" @default.
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- W2092942673 abstract "Although the hemodynamic response to polymicrobial sepsis is characterized by an early, hyperdynamic phase followed by a late, hypodynamic phase, the factors responsible for producing the transition from the hyperdynamic to the hypodynamic stage are not fully understood. The failure to recognize or prevent this transition may lead to progressive deteriorations in cell and organ functions and ultimately result in multiple organ failure. Despite the fact that several vasoactive mediators (i.e., nitric oxide, prostacyclin, calcitonin gene-related peptide) have been implicated in producing cardiovascular alterations during sepsis, recent studies have indicated that adrenomedullin (AM), a novel vasodilatory peptide, plays an important role in initiating the hyperdynamic response during the early stage of polymicrobial sepsis. In addition, the reduced vascular responsiveness appears to be responsible for producing the transition from the early, hyperdynamic phase to the late, hypodynamic phase of sepsis. Moreover, modulation of AM vascular responsiveness reduces sepsis-induced mortality. In this review the physiological effects of AM, mechanisms of its action, and regulation of its production under various pathophysiological conditions will be discussed. Furthermore, the role of AM in producing the biphasic hemodynamic responses observed during polymicrobial sepsis and approaches for pharmacologically modulating vascular responsiveness and hemodynamic stability under such conditions will be described." @default.
- W2092942673 created "2016-06-24" @default.
- W2092942673 creator A5025135549 @default.
- W2092942673 creator A5073353122 @default.
- W2092942673 creator A5084966628 @default.
- W2092942673 creator A5085171919 @default.
- W2092942673 date "2001-02-01" @default.
- W2092942673 modified "2023-09-23" @default.
- W2092942673 title "The Role of Adrenomedullin in Producing Differential Hemodynamic Responses during Sepsis" @default.
- W2092942673 cites W1496300019 @default.
- W2092942673 cites W1514452974 @default.
- W2092942673 cites W168146901 @default.
- W2092942673 cites W1954023508 @default.
- W2092942673 cites W1964207919 @default.
- W2092942673 cites W1966485962 @default.
- W2092942673 cites W1966952945 @default.
- W2092942673 cites W1971910159 @default.
- W2092942673 cites W1973769926 @default.
- W2092942673 cites W1973970183 @default.
- W2092942673 cites W1975319050 @default.
- W2092942673 cites W1977391267 @default.
- W2092942673 cites W1978289807 @default.
- W2092942673 cites W1978862133 @default.
- W2092942673 cites W1979439670 @default.
- W2092942673 cites W1980334357 @default.
- W2092942673 cites W1980985994 @default.
- W2092942673 cites W1980988043 @default.
- W2092942673 cites W1981492597 @default.
- W2092942673 cites W1982290807 @default.
- W2092942673 cites W1988386616 @default.
- W2092942673 cites W1989219046 @default.
- W2092942673 cites W1990768815 @default.
- W2092942673 cites W1992207523 @default.
- W2092942673 cites W1996571691 @default.
- W2092942673 cites W1997873010 @default.
- W2092942673 cites W1999136239 @default.
- W2092942673 cites W1999582787 @default.
- W2092942673 cites W2002017720 @default.
- W2092942673 cites W2005276110 @default.
- W2092942673 cites W2005759059 @default.
- W2092942673 cites W2014138060 @default.
- W2092942673 cites W2014597168 @default.
- W2092942673 cites W2017585061 @default.
- W2092942673 cites W2022579067 @default.
- W2092942673 cites W2023541036 @default.
- W2092942673 cites W2023818295 @default.
- W2092942673 cites W2024001709 @default.
- W2092942673 cites W2024795227 @default.
- W2092942673 cites W2029787195 @default.
- W2092942673 cites W2035433014 @default.
- W2092942673 cites W2035476626 @default.
- W2092942673 cites W2036031516 @default.
- W2092942673 cites W2036983784 @default.
- W2092942673 cites W2037588629 @default.
- W2092942673 cites W2039711337 @default.
- W2092942673 cites W2041077071 @default.
- W2092942673 cites W2041669340 @default.
- W2092942673 cites W2042438672 @default.
- W2092942673 cites W2042781468 @default.
- W2092942673 cites W2044073735 @default.
- W2092942673 cites W2049872985 @default.
- W2092942673 cites W2052303540 @default.
- W2092942673 cites W2052923531 @default.
- W2092942673 cites W2053731747 @default.
- W2092942673 cites W2054385742 @default.
- W2092942673 cites W2061451792 @default.
- W2092942673 cites W2063308606 @default.
- W2092942673 cites W2066837470 @default.
- W2092942673 cites W2067695080 @default.
- W2092942673 cites W2070625301 @default.
- W2092942673 cites W2070743921 @default.
- W2092942673 cites W2071000520 @default.
- W2092942673 cites W2074295150 @default.
- W2092942673 cites W2074962294 @default.
- W2092942673 cites W2075790751 @default.
- W2092942673 cites W2076574971 @default.
- W2092942673 cites W2083350408 @default.
- W2092942673 cites W2084201100 @default.
- W2092942673 cites W2084300836 @default.
- W2092942673 cites W2084400824 @default.
- W2092942673 cites W2087050018 @default.
- W2092942673 cites W2088007858 @default.
- W2092942673 cites W2088437275 @default.
- W2092942673 cites W2089522615 @default.
- W2092942673 cites W2089598030 @default.
- W2092942673 cites W2089873717 @default.
- W2092942673 cites W2092419989 @default.
- W2092942673 cites W2093057855 @default.
- W2092942673 cites W2094958645 @default.
- W2092942673 cites W2095189647 @default.
- W2092942673 cites W2110163942 @default.
- W2092942673 cites W2111112233 @default.
- W2092942673 cites W2118132608 @default.
- W2092942673 cites W2119370017 @default.
- W2092942673 cites W2124559121 @default.
- W2092942673 cites W2130036936 @default.
- W2092942673 cites W2147665627 @default.
- W2092942673 cites W2149013679 @default.