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• W2092948999 abstract "Background Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder characterized by the progressive development of renal and hepatic cysts. Follicle-stimulating hormone (FSH) has been demonstrated to be a trophic factor for biliary cells in normal rats and experimental cholestasis induced by bile duct ligation (BDL). Aims To assess the effect of FSH on cholangiocyte proliferation during ADPKD using both in vivo and in vitro models. Methods Evaluation of FSH receptor (FSHR), FSH, phospho-extracellular-regulated kinase (pERK) and c-myc expression in liver fragments from normal patients and patients with ADPKD. In vitro, we studied proliferating cell nuclear antigen (PCNA) and cAMP levels in a human immortalized, non-malignant cholangiocyte cell line (H69) and in an immortalized cell line obtained from the epithelium lining the hepatic cysts from the patients with ADPKD (LCDE) with or without transient silencing of the FSH gene. Results Follicle-stimulating hormone is linked to the active proliferation of the cystic wall and to the localization of p-ERK and c-myc. This hormone sustains the biliary growth by activation of the cAMP/ERK signalling pathway. Conclusion These results showed that FSH has an important function in cystic growth acting on the cAMP pathway, demonstrating that it provides a target for medical therapy of hepatic cysts during ADPKD." @default.
• W2092948999 created "2016-06-24" @default.
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• W2092948999 date "2013-04-25" @default.
• W2092948999 modified "2023-10-17" @default.
• W2092948999 title "Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease" @default.
• W2092948999 cites W100165276 @default.
• W2092948999 cites W1492104840 @default.
• W2092948999 cites W1580893558 @default.
• W2092948999 cites W1875082729 @default.
• W2092948999 cites W1908700199 @default.
• W2092948999 cites W1967667628 @default.
• W2092948999 cites W1968969832 @default.
• W2092948999 cites W1969000560 @default.
• W2092948999 cites W1972496381 @default.
• W2092948999 cites W1980844512 @default.
• W2092948999 cites W1982708256 @default.
• W2092948999 cites W1983197316 @default.
• W2092948999 cites W1985109279 @default.
• W2092948999 cites W1989461823 @default.
• W2092948999 cites W1995012620 @default.
• W2092948999 cites W1999095798 @default.
• W2092948999 cites W2000763401 @default.
• W2092948999 cites W2001988515 @default.
• W2092948999 cites W2005026678 @default.
• W2092948999 cites W2011924388 @default.
• W2092948999 cites W2012527044 @default.
• W2092948999 cites W2014214553 @default.
• W2092948999 cites W2014233742 @default.
• W2092948999 cites W2018767335 @default.
• W2092948999 cites W2021594260 @default.
• W2092948999 cites W2024488205 @default.
• W2092948999 cites W2029303787 @default.
• W2092948999 cites W2032228150 @default.
• W2092948999 cites W2033135582 @default.
• W2092948999 cites W2034693702 @default.
• W2092948999 cites W2036848803 @default.
• W2092948999 cites W2037381750 @default.
• W2092948999 cites W2038341639 @default.
• W2092948999 cites W2056794794 @default.
• W2092948999 cites W2062999758 @default.
• W2092948999 cites W2070558024 @default.
• W2092948999 cites W2078292875 @default.
• W2092948999 cites W2081228978 @default.
• W2092948999 cites W2085690923 @default.
• W2092948999 cites W2088867776 @default.
• W2092948999 cites W2089636225 @default.
• W2092948999 cites W2090239109 @default.
• W2092948999 cites W2090300078 @default.
• W2092948999 cites W2092850262 @default.
• W2092948999 cites W2095869636 @default.
• W2092948999 cites W2102109538 @default.
• W2092948999 cites W2106119346 @default.
• W2092948999 cites W2120106989 @default.
• W2092948999 cites W2128759136 @default.
• W2092948999 cites W2133648805 @default.
• W2092948999 cites W2135355383 @default.
• W2092948999 cites W2141935987 @default.
• W2092948999 cites W2143609597 @default.
• W2092948999 cites W2146597400 @default.
• W2092948999 cites W2147196233 @default.
• W2092948999 cites W2147417412 @default.
• W2092948999 cites W2149793328 @default.
• W2092948999 cites W2151925930 @default.
• W2092948999 cites W2159101760 @default.
• W2092948999 cites W2163623286 @default.
• W2092948999 cites W2164080063 @default.
• W2092948999 cites W2166743029 @default.
• W2092948999 cites W2167512484 @default.
• W2092948999 cites W2167714337 @default.
• W2092948999 cites W2167881829 @default.
• W2092948999 cites W2187923669 @default.
• W2092948999 cites W35381647 @default.
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• W2092948999 doi "https://doi.org/10.1111/liv.12177" @default.
• W2092948999 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4064944" @default.
• W2092948999 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23617956" @default.
• W2092948999 hasPublicationYear "2013" @default.
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