FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092968923> ?p ?o ?g. }

• W2092968923 abstract "Neurotensin (NT) receptor subtypes were investigated in nine brain regions from long sleep (LS) and short sleep (SS) mice that were selectively bred for differences in sensitivity to ethanol. Differences in NT receptor densities may mediate, in part, genetically selected differences in ethanol sensitivity between the two lines of mice. The use of [3H] NT at concentrations from 0.02 to 20 nM yielded biphasic binding isotherms as revealed by Scatchard analysis. Membranes from LS ventral midbrain yielded dissociation constants (KD values) of 0.34 and 3.85 nM for the high (NTH) and low (NTL) affinity components, respectively. SS membranes displayed similar KD values, however the maximum number of binding sites (Bmax) for both receptor subtypes were significantly greater in SS than in LS membranes (46.7 vs. 71.5 fmol/mg protein for NTH and 170.2 vs. 208.2 fmol/mg protein for NTL). Using levocabastine, and H1 antagonist with selectivity for NTL, characterization of NTH and NTL binding in nine brain regions was performed. In general, membranes from each brain region of SS mice had higher densities than LS for both receptor subtypes. Significant differences for the total density of receptors and NTL were found in entorhinal cortex, nucleus accumbens, hippocampus, and ventral midbrain. The only region to differ in NTH was the ventral midbrain. Competition experiments using various NT fragments to compete for NTH binding showed the C-terminal amino acids to be essential for binding. The order of potency was NT1-13 = NT8-13 greater than Neuromedin N greater than NT1-8 = NT1-11." @default.
• W2092968923 created "2016-06-24" @default.
• W2092968923 creator A5034631528 @default.
• W2092968923 creator A5050125034 @default.
• W2092968923 creator A5057003584 @default.
• W2092968923 date "1991-11-01" @default.
• W2092968923 modified "2023-09-23" @default.
• W2092968923 title "Regional Characterization of Brain Neurotensin Receptor Subtypes in LS and SS Mice" @default.
• W2092968923 cites W1480715733 @default.
• W2092968923 cites W1487686100 @default.
• W2092968923 cites W1573974844 @default.
• W2092968923 cites W1607957872 @default.
• W2092968923 cites W1684853394 @default.
• W2092968923 cites W1775749144 @default.
• W2092968923 cites W1967037725 @default.
• W2092968923 cites W1968220226 @default.
• W2092968923 cites W1971239645 @default.
• W2092968923 cites W1972700598 @default.
• W2092968923 cites W1975961987 @default.
• W2092968923 cites W1983956535 @default.
• W2092968923 cites W1995545889 @default.
• W2092968923 cites W1996660130 @default.
• W2092968923 cites W1997839253 @default.
• W2092968923 cites W2010280935 @default.
• W2092968923 cites W2013363587 @default.
• W2092968923 cites W2027773672 @default.
• W2092968923 cites W2032566097 @default.
• W2092968923 cites W2034716179 @default.
• W2092968923 cites W2041110976 @default.
• W2092968923 cites W2042605308 @default.
• W2092968923 cites W2043589738 @default.
• W2092968923 cites W2044948606 @default.
• W2092968923 cites W2051270911 @default.
• W2092968923 cites W2052969077 @default.
• W2092968923 cites W2072248623 @default.
• W2092968923 cites W2076291793 @default.
• W2092968923 cites W2082127987 @default.
• W2092968923 cites W2082399297 @default.
• W2092968923 cites W2082905630 @default.
• W2092968923 cites W2091129282 @default.
• W2092968923 cites W2159939112 @default.
• W2092968923 cites W957480215 @default.
• W2092968923 cites W1983876343 @default.
• W2092968923 doi "https://doi.org/10.1111/j.1530-0277.1991.tb05203.x" @default.
• W2092968923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1686369" @default.
• W2092968923 hasPublicationYear "1991" @default.
• W2092968923 type Work @default.
• W2092968923 sameAs 2092968923 @default.
• W2092968923 citedByCount "17" @default.
• W2092968923 countsByYear W20929689232013 @default.
• W2092968923 crossrefType "journal-article" @default.
• W2092968923 hasAuthorship W2092968923A5034631528 @default.
• W2092968923 hasAuthorship W2092968923A5050125034 @default.
• W2092968923 hasAuthorship W2092968923A5057003584 @default.
• W2092968923 hasConcept C118303440 @default.
• W2092968923 hasConcept C12554922 @default.
• W2092968923 hasConcept C126322002 @default.
• W2092968923 hasConcept C134018914 @default.
• W2092968923 hasConcept C153911025 @default.
• W2092968923 hasConcept C170493617 @default.
• W2092968923 hasConcept C185592680 @default.
• W2092968923 hasConcept C2776552330 @default.
• W2092968923 hasConcept C2777307743 @default.
• W2092968923 hasConcept C2778938600 @default.
• W2092968923 hasConcept C2778976297 @default.
• W2092968923 hasConcept C2780715579 @default.
• W2092968923 hasConcept C2781161787 @default.
• W2092968923 hasConcept C529278444 @default.
• W2092968923 hasConcept C552161191 @default.
• W2092968923 hasConcept C55493867 @default.
• W2092968923 hasConcept C71924100 @default.
• W2092968923 hasConcept C86803240 @default.
• W2092968923 hasConceptScore W2092968923C118303440 @default.
• W2092968923 hasConceptScore W2092968923C12554922 @default.
• W2092968923 hasConceptScore W2092968923C126322002 @default.
• W2092968923 hasConceptScore W2092968923C134018914 @default.
• W2092968923 hasConceptScore W2092968923C153911025 @default.
• W2092968923 hasConceptScore W2092968923C170493617 @default.
• W2092968923 hasConceptScore W2092968923C185592680 @default.
• W2092968923 hasConceptScore W2092968923C2776552330 @default.
• W2092968923 hasConceptScore W2092968923C2777307743 @default.
• W2092968923 hasConceptScore W2092968923C2778938600 @default.
• W2092968923 hasConceptScore W2092968923C2778976297 @default.
• W2092968923 hasConceptScore W2092968923C2780715579 @default.
• W2092968923 hasConceptScore W2092968923C2781161787 @default.
• W2092968923 hasConceptScore W2092968923C529278444 @default.
• W2092968923 hasConceptScore W2092968923C552161191 @default.
• W2092968923 hasConceptScore W2092968923C55493867 @default.
• W2092968923 hasConceptScore W2092968923C71924100 @default.
• W2092968923 hasConceptScore W2092968923C86803240 @default.
• W2092968923 hasLocation W20929689231 @default.
• W2092968923 hasLocation W20929689232 @default.
• W2092968923 hasOpenAccess W2092968923 @default.
• W2092968923 hasPrimaryLocation W20929689231 @default.
• W2092968923 hasRelatedWork W1559212726 @default.
• W2092968923 hasRelatedWork W2002240883 @default.
• W2092968923 hasRelatedWork W2047083510 @default.
• W2092968923 hasRelatedWork W2065375621 @default.
• W2092968923 hasRelatedWork W2087759102 @default.
• W2092968923 hasRelatedWork W2092224264 @default.

• next