FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092973313> ?p ?o ?g. }

• W2092973313 endingPage "1283" @default.
• W2092973313 startingPage "1277" @default.
• W2092973313 abstract "Activity of the epithelial sodium channels (ENaCs) in the lung tissue plays a critical role on sodium/fluid homeostasis and the lung fluid clearance. The serum- and glucocorticoid-inducible kinase-1 (SGK1), one of the critical regulation proteins of ENaC, is activated by insulin and growth factors possibly through 3-phosphoinositide-dependent kinase PDK1 or/and phosphatidylinositol 3-kinase (PI3K). However, it is uncertain whether insulin shows its stimulatory action on ENaC by activation of SGK1 in lipopolysaccharide (LPS)-induced acute lung injury (ALI) condition. In our study, Wistar rats were injected with LPS to induce ALI. Evans blue dye albumin (EBA) concentration was used to measure pulmonary oedema. For detecting the ratio of phospho-SGK1/SGK1 and α-ENaC protein, Western blot was performed. Real-time polymerase chain reaction (RT-PCR) was used to assess α-ENaC messenger RNA (mRNA). Immunohistochemistry was used to locate and quantitate α-ENaC expression. The EBA concentration was markedly increased by LPS alone but significantly reduced in rats that also received insulin injection. The ratio of phospho-SGK1/SGK1 was raised significantly in the insulin group and insulin + LPS group, compared with the control group and the LPS group, respectively. Furthermore, α-ENaC was up-regulated by insulin treatment. Simultaneously, injection with LPS significantly reduced α-ENaC expression. These findings demonstrated that insulin up-regulates ENaC in vivo possibly resulting from activation of SGK1." @default.
• W2092973313 created "2016-06-24" @default.
• W2092973313 creator A5002139784 @default.
• W2092973313 creator A5006876375 @default.
• W2092973313 creator A5007529548 @default.
• W2092973313 date "2012-08-01" @default.
• W2092973313 modified "2023-09-29" @default.
• W2092973313 title "Insulin up-regulates epithelial sodium channel in LPS-induced acute lung injury model in rats by SGK1 activation" @default.
• W2092973313 cites W1486524131 @default.
• W2092973313 cites W1970920862 @default.
• W2092973313 cites W1971426502 @default.
• W2092973313 cites W1980717583 @default.
• W2092973313 cites W1991940875 @default.
• W2092973313 cites W2003029950 @default.
• W2092973313 cites W2008696153 @default.
• W2092973313 cites W2009649501 @default.
• W2092973313 cites W2017944747 @default.
• W2092973313 cites W2020265991 @default.
• W2092973313 cites W2024281548 @default.
• W2092973313 cites W2060189309 @default.
• W2092973313 cites W2064500677 @default.
• W2092973313 cites W2072043915 @default.
• W2092973313 cites W2087499467 @default.
• W2092973313 cites W2090117730 @default.
• W2092973313 cites W2091531959 @default.
• W2092973313 cites W2110305256 @default.
• W2092973313 cites W2113770601 @default.
• W2092973313 cites W2121009129 @default.
• W2092973313 cites W2142656747 @default.
• W2092973313 cites W2149309380 @default.
• W2092973313 cites W2152331398 @default.
• W2092973313 cites W2161328469 @default.
• W2092973313 cites W2171989184 @default.
• W2092973313 cites W2172109574 @default.
• W2092973313 cites W2177611930 @default.
• W2092973313 cites W2301973105 @default.
• W2092973313 cites W2334530874 @default.
• W2092973313 cites W4211084754 @default.
• W2092973313 cites W4232299335 @default.
• W2092973313 cites W4294658238 @default.
• W2092973313 doi "https://doi.org/10.1016/j.injury.2012.04.004" @default.
• W2092973313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22552040" @default.
• W2092973313 hasPublicationYear "2012" @default.
• W2092973313 type Work @default.
• W2092973313 sameAs 2092973313 @default.
• W2092973313 citedByCount "32" @default.
• W2092973313 countsByYear W20929733132012 @default.
• W2092973313 countsByYear W20929733132013 @default.
• W2092973313 countsByYear W20929733132014 @default.
• W2092973313 countsByYear W20929733132015 @default.
• W2092973313 countsByYear W20929733132016 @default.
• W2092973313 countsByYear W20929733132017 @default.
• W2092973313 countsByYear W20929733132018 @default.
• W2092973313 countsByYear W20929733132019 @default.
• W2092973313 countsByYear W20929733132020 @default.
• W2092973313 countsByYear W20929733132021 @default.
• W2092973313 countsByYear W20929733132022 @default.
• W2092973313 crossrefType "journal-article" @default.
• W2092973313 hasAuthorship W2092973313A5002139784 @default.
• W2092973313 hasAuthorship W2092973313A5006876375 @default.
• W2092973313 hasAuthorship W2092973313A5007529548 @default.
• W2092973313 hasConcept C104317684 @default.
• W2092973313 hasConcept C126322002 @default.
• W2092973313 hasConcept C127561419 @default.
• W2092973313 hasConcept C134018914 @default.
• W2092973313 hasConcept C178790620 @default.
• W2092973313 hasConcept C184150571 @default.
• W2092973313 hasConcept C184235292 @default.
• W2092973313 hasConcept C185592680 @default.
• W2092973313 hasConcept C2776415932 @default.
• W2092973313 hasConcept C2778754761 @default.
• W2092973313 hasConcept C2779306644 @default.
• W2092973313 hasConcept C2780610907 @default.
• W2092973313 hasConcept C2780841215 @default.
• W2092973313 hasConcept C537181965 @default.
• W2092973313 hasConcept C55493867 @default.
• W2092973313 hasConcept C6507245 @default.
• W2092973313 hasConcept C71924100 @default.
• W2092973313 hasConceptScore W2092973313C104317684 @default.
• W2092973313 hasConceptScore W2092973313C126322002 @default.
• W2092973313 hasConceptScore W2092973313C127561419 @default.
• W2092973313 hasConceptScore W2092973313C134018914 @default.
• W2092973313 hasConceptScore W2092973313C178790620 @default.
• W2092973313 hasConceptScore W2092973313C184150571 @default.
• W2092973313 hasConceptScore W2092973313C184235292 @default.
• W2092973313 hasConceptScore W2092973313C185592680 @default.
• W2092973313 hasConceptScore W2092973313C2776415932 @default.
• W2092973313 hasConceptScore W2092973313C2778754761 @default.
• W2092973313 hasConceptScore W2092973313C2779306644 @default.
• W2092973313 hasConceptScore W2092973313C2780610907 @default.
• W2092973313 hasConceptScore W2092973313C2780841215 @default.
• W2092973313 hasConceptScore W2092973313C537181965 @default.
• W2092973313 hasConceptScore W2092973313C55493867 @default.
• W2092973313 hasConceptScore W2092973313C6507245 @default.
• W2092973313 hasConceptScore W2092973313C71924100 @default.
• W2092973313 hasIssue "8" @default.
• W2092973313 hasLocation W20929733131 @default.
• W2092973313 hasLocation W20929733132 @default.

• next