FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092973670> ?p ?o ?g. }

• W2092973670 endingPage "213" @default.
• W2092973670 startingPage "206" @default.
• W2092973670 abstract "The relative affinity of molybdocene dichloride (Cp(2)MoCl(2)) for the thiol, amino, carboxylate, phosphate(O) and heterocyclic(N) donor ligands present in amino acids and nucleotides, has been studied in aqueous solutions at pH 2-7, using (1)H, (13)C and (31)P NMR spectroscopy. Molybdocene dichloride forms the highly water soluble, air-stable complexes Cp(2)Mo(Cys)(2) and Cp(2)Mo(GS)(2) with cysteine and glutathione respectively, via coordination of the deprotonated thiol groups. While coordination to the imidazole nitrogen in histidine was observed, no evidence for coordination of the amino or carboxylate groups in the amino acids cysteine, histidine, alanine or lysine to Cp(2)MoCl(2) was detected. Competition experiments with dAMP, ribose monophosphate and histidine showed preferential coordination to the cysteine thiol over the phosphate(O) and heterocyclic(N) groups. Cp(2)Mo(Cys)(2) is stable in the presence of excess dAMP or ribose monophosphate and Cys displaces coordinated histidine, dAMP or ribose monophosphate to give Cp(2)Mo(Cys)(2). These results provide further evidence against interaction with DNA as the key interaction that is related to the antitumor activity of molybdocene dichloride. The implications of these results for the biological activity of the antitumor metallocene and the likely species formed in vivo are discussed." @default.
• W2092973670 created "2016-06-24" @default.
• W2092973670 creator A5041073658 @default.
• W2092973670 creator A5059883521 @default.
• W2092973670 date "2003-12-03" @default.
• W2092973670 modified "2023-10-16" @default.
• W2092973670 title "Coordination Chemistry of the Antitumor Metallocene Molybdocene Dichloride with Biological Ligands" @default.
• W2092973670 cites W133898051 @default.
• W2092973670 cites W1967495266 @default.
• W2092973670 cites W1969722215 @default.
• W2092973670 cites W1973591492 @default.
• W2092973670 cites W1974075450 @default.
• W2092973670 cites W1978612964 @default.
• W2092973670 cites W1980637183 @default.
• W2092973670 cites W1981519760 @default.
• W2092973670 cites W1982125147 @default.
• W2092973670 cites W1991565868 @default.
• W2092973670 cites W1991588605 @default.
• W2092973670 cites W2001821796 @default.
• W2092973670 cites W2017030176 @default.
• W2092973670 cites W2032291871 @default.
• W2092973670 cites W2039102028 @default.
• W2092973670 cites W2040529066 @default.
• W2092973670 cites W2041363678 @default.
• W2092973670 cites W2052597254 @default.
• W2092973670 cites W2056893453 @default.
• W2092973670 cites W2070896353 @default.
• W2092973670 cites W2073952053 @default.
• W2092973670 cites W2079946015 @default.
• W2092973670 cites W2083433470 @default.
• W2092973670 cites W2084240113 @default.
• W2092973670 cites W2085137152 @default.
• W2092973670 cites W2092889823 @default.
• W2092973670 cites W2136006702 @default.
• W2092973670 cites W2231516589 @default.
• W2092973670 cites W2241061912 @default.
• W2092973670 cites W2943284274 @default.
• W2092973670 cites W2950624003 @default.
• W2092973670 cites W3004576110 @default.
• W2092973670 cites W4254616385 @default.
• W2092973670 doi "https://doi.org/10.1021/ic034892q" @default.
• W2092973670 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14704069" @default.
• W2092973670 hasPublicationYear "2003" @default.
• W2092973670 type Work @default.
• W2092973670 sameAs 2092973670 @default.
• W2092973670 citedByCount "45" @default.
• W2092973670 countsByYear W20929736702012 @default.
• W2092973670 countsByYear W20929736702013 @default.
• W2092973670 countsByYear W20929736702014 @default.
• W2092973670 countsByYear W20929736702015 @default.
• W2092973670 countsByYear W20929736702017 @default.
• W2092973670 countsByYear W20929736702018 @default.
• W2092973670 countsByYear W20929736702019 @default.
• W2092973670 countsByYear W20929736702022 @default.
• W2092973670 crossrefType "journal-article" @default.
• W2092973670 hasAuthorship W2092973670A5041073658 @default.
• W2092973670 hasAuthorship W2092973670A5059883521 @default.
• W2092973670 hasConcept C118629725 @default.
• W2092973670 hasConcept C145148216 @default.
• W2092973670 hasConcept C155647269 @default.
• W2092973670 hasConcept C178790620 @default.
• W2092973670 hasConcept C181199279 @default.
• W2092973670 hasConcept C185592680 @default.
• W2092973670 hasConcept C2778074193 @default.
• W2092973670 hasConcept C2778460671 @default.
• W2092973670 hasConcept C2779201268 @default.
• W2092973670 hasConcept C2779461342 @default.
• W2092973670 hasConcept C2781324293 @default.
• W2092973670 hasConcept C515207424 @default.
• W2092973670 hasConcept C55493867 @default.
• W2092973670 hasConcept C71240020 @default.
• W2092973670 hasConceptScore W2092973670C118629725 @default.
• W2092973670 hasConceptScore W2092973670C145148216 @default.
• W2092973670 hasConceptScore W2092973670C155647269 @default.
• W2092973670 hasConceptScore W2092973670C178790620 @default.
• W2092973670 hasConceptScore W2092973670C181199279 @default.
• W2092973670 hasConceptScore W2092973670C185592680 @default.
• W2092973670 hasConceptScore W2092973670C2778074193 @default.
• W2092973670 hasConceptScore W2092973670C2778460671 @default.
• W2092973670 hasConceptScore W2092973670C2779201268 @default.
• W2092973670 hasConceptScore W2092973670C2779461342 @default.
• W2092973670 hasConceptScore W2092973670C2781324293 @default.
• W2092973670 hasConceptScore W2092973670C515207424 @default.
• W2092973670 hasConceptScore W2092973670C55493867 @default.
• W2092973670 hasConceptScore W2092973670C71240020 @default.
• W2092973670 hasIssue "1" @default.
• W2092973670 hasLocation W20929736701 @default.
• W2092973670 hasLocation W20929736702 @default.
• W2092973670 hasOpenAccess W2092973670 @default.
• W2092973670 hasPrimaryLocation W20929736701 @default.
• W2092973670 hasRelatedWork W1980129044 @default.
• W2092973670 hasRelatedWork W1989081025 @default.
• W2092973670 hasRelatedWork W2001920378 @default.
• W2092973670 hasRelatedWork W2012479140 @default.
• W2092973670 hasRelatedWork W2013253286 @default.
• W2092973670 hasRelatedWork W2015247279 @default.
• W2092973670 hasRelatedWork W2092973670 @default.
• W2092973670 hasRelatedWork W2140329238 @default.

• next