FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092979815> ?p ?o ?g. }

• W2092979815 endingPage "25" @default.
• W2092979815 startingPage "17" @default.
• W2092979815 abstract "Carcinogenicity is a complex endpoint of high concern yet the rodent bioassay still used is costly to run in terms of time, money and animals. Therefore carcinogenicity has been the subject of many different efforts to both develop short-term tests and non-testing approaches capable of predicting genotoxic carcinogenic potential. In our previous publication (Mekenyan et al., 2012) we presented an in vitro-in vivo extrapolation workflow to help investigate the differences between in vitro and in vivo genotoxicity tests. The outcomes facilitated the development of new (Q)SAR models and for directing testing. Here we have refined this workflow by grouping specific tests together on the basis of their ability to detect DNA and/or protein damage at different levels of biological organization. This revised workflow, akin to an Integrated Approach to Testing and Assessment (IATA) informed by mechanistic understanding was helpful in rationalizing inconsistent study outcomes and categorizing a test set of carcinogens with mutagenicity data on the basis of regulatory mutagenicity classifications. Rodent genotoxic carcinogens were found to be correctly predicted with a high sensitivity (90-100%) and a low rate of false positives (3-10%). The insights derived are useful to consider when developing future (non-)testing approaches to address regulatory purposes." @default.
• W2092979815 created "2016-06-24" @default.
• W2092979815 creator A5005029428 @default.
• W2092979815 creator A5016368712 @default.
• W2092979815 creator A5031891942 @default.
• W2092979815 creator A5034652034 @default.
• W2092979815 creator A5042404534 @default.
• W2092979815 creator A5062895826 @default.
• W2092979815 creator A5063324664 @default.
• W2092979815 creator A5072354171 @default.
• W2092979815 creator A5072378025 @default.
• W2092979815 date "2015-06-01" @default.
• W2092979815 modified "2023-09-26" @default.
• W2092979815 title "A feasibility study: Can information collected to classify for mutagenicity be informative in predicting carcinogenicity?" @default.
• W2092979815 cites W129251135 @default.
• W2092979815 cites W1526446653 @default.
• W2092979815 cites W1973879072 @default.
• W2092979815 cites W1975827721 @default.
• W2092979815 cites W1988562694 @default.
• W2092979815 cites W1991095464 @default.
• W2092979815 cites W1991871732 @default.
• W2092979815 cites W1994122604 @default.
• W2092979815 cites W2000089305 @default.
• W2092979815 cites W2004326614 @default.
• W2092979815 cites W2004678494 @default.
• W2092979815 cites W2006882273 @default.
• W2092979815 cites W2007420389 @default.
• W2092979815 cites W2008207702 @default.
• W2092979815 cites W2008838636 @default.
• W2092979815 cites W2009077052 @default.
• W2092979815 cites W2013938779 @default.
• W2092979815 cites W2034485370 @default.
• W2092979815 cites W2066517594 @default.
• W2092979815 cites W2073169035 @default.
• W2092979815 cites W2092202938 @default.
• W2092979815 cites W2095872575 @default.
• W2092979815 cites W2132224561 @default.
• W2092979815 cites W2404362748 @default.
• W2092979815 cites W2416010609 @default.
• W2092979815 cites W4235201712 @default.
• W2092979815 cites W84089843 @default.
• W2092979815 doi "https://doi.org/10.1016/j.yrtph.2015.03.003" @default.
• W2092979815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25792138" @default.
• W2092979815 hasPublicationYear "2015" @default.
• W2092979815 type Work @default.
• W2092979815 sameAs 2092979815 @default.
• W2092979815 citedByCount "15" @default.
• W2092979815 countsByYear W20929798152015 @default.
• W2092979815 countsByYear W20929798152016 @default.
• W2092979815 countsByYear W20929798152017 @default.
• W2092979815 countsByYear W20929798152019 @default.
• W2092979815 countsByYear W20929798152020 @default.
• W2092979815 countsByYear W20929798152021 @default.
• W2092979815 countsByYear W20929798152022 @default.
• W2092979815 countsByYear W20929798152023 @default.
• W2092979815 crossrefType "journal-article" @default.
• W2092979815 hasAuthorship W2092979815A5005029428 @default.
• W2092979815 hasAuthorship W2092979815A5016368712 @default.
• W2092979815 hasAuthorship W2092979815A5031891942 @default.
• W2092979815 hasAuthorship W2092979815A5034652034 @default.
• W2092979815 hasAuthorship W2092979815A5042404534 @default.
• W2092979815 hasAuthorship W2092979815A5062895826 @default.
• W2092979815 hasAuthorship W2092979815A5063324664 @default.
• W2092979815 hasAuthorship W2092979815A5072354171 @default.
• W2092979815 hasAuthorship W2092979815A5072378025 @default.
• W2092979815 hasConcept C114246631 @default.
• W2092979815 hasConcept C127413603 @default.
• W2092979815 hasConcept C154945302 @default.
• W2092979815 hasConcept C177212765 @default.
• W2092979815 hasConcept C177264268 @default.
• W2092979815 hasConcept C178790620 @default.
• W2092979815 hasConcept C183696295 @default.
• W2092979815 hasConcept C185592680 @default.
• W2092979815 hasConcept C199360897 @default.
• W2092979815 hasConcept C2778959862 @default.
• W2092979815 hasConcept C29730261 @default.
• W2092979815 hasConcept C33070731 @default.
• W2092979815 hasConcept C41008148 @default.
• W2092979815 hasConcept C54355233 @default.
• W2092979815 hasConcept C64869954 @default.
• W2092979815 hasConcept C70721500 @default.
• W2092979815 hasConcept C77088390 @default.
• W2092979815 hasConcept C86803240 @default.
• W2092979815 hasConceptScore W2092979815C114246631 @default.
• W2092979815 hasConceptScore W2092979815C127413603 @default.
• W2092979815 hasConceptScore W2092979815C154945302 @default.
• W2092979815 hasConceptScore W2092979815C177212765 @default.
• W2092979815 hasConceptScore W2092979815C177264268 @default.
• W2092979815 hasConceptScore W2092979815C178790620 @default.
• W2092979815 hasConceptScore W2092979815C183696295 @default.
• W2092979815 hasConceptScore W2092979815C185592680 @default.
• W2092979815 hasConceptScore W2092979815C199360897 @default.
• W2092979815 hasConceptScore W2092979815C2778959862 @default.
• W2092979815 hasConceptScore W2092979815C29730261 @default.
• W2092979815 hasConceptScore W2092979815C33070731 @default.
• W2092979815 hasConceptScore W2092979815C41008148 @default.
• W2092979815 hasConceptScore W2092979815C54355233 @default.
• W2092979815 hasConceptScore W2092979815C64869954 @default.

• next