FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092984904> ?p ?o ?g. }

• W2092984904 endingPage "752" @default.
• W2092984904 startingPage "743" @default.
• W2092984904 abstract "The persistent maintenance of long-term potentiation requires both messenger RNA and protein synthesis. While there is mounting evidence for an active role of protein synthesis in hippocampal long-term potentiation, the nature of mechanisms underlying its regulation has not yet been established. We used a previously described chemical long-term potentiation protocol [J Neurosci 19 (1999) 2500] to address the hypothesis that signaling mechanisms, involved in long-lasting long-term potentiation, directly regulate protein synthesis. Chemical long-term potentiation is an N-methyl-D-aspartate receptor-dependent form of plasticity, which relies on both synaptic activity, in the form of spontaneous bursting induced by high concentrations of K(+) and Ca(2+), and cyclic AMP/adenylyl cyclase signaling. We found that chemical long-term potentiation in CA1 of the mouse hippocampus lasts for at least 3 hours and requires both messenger RNA and protein synthesis. However, surprisingly de novo total protein synthesis was paradoxically decreased at 1 hour after long-term potentiation induction. Consistent with the decrease in total protein synthesis in potentiated CA1, phosphorylation of eukaryotic elongation factor 2 was increased and is likely responsible for inhibition of translation at the elongation step. Increased phosphorylation of eukaryotic elongation factor 2 was dependent on coincident cyclic AMP/adenylyl cyclase activation and synaptic activity and required N-methyl-D-aspartate receptor activation. Despite the inhibition in total protein synthesis, the level of the immediate early gene protein Arc (activity regulated cytoskeleton-associated protein) increased at 1 hour after chemical long-term potentiation induction. Taken together, the results suggest that regulation at the elongation step of protein synthesis contributes to persistent forms of long-term potentiation." @default.
• W2092984904 created "2016-06-24" @default.
• W2092984904 creator A5008354384 @default.
• W2092984904 creator A5032456571 @default.
• W2092984904 creator A5058824296 @default.
• W2092984904 creator A5059996026 @default.
• W2092984904 creator A5068972113 @default.
• W2092984904 date "2003-02-01" @default.
• W2092984904 modified "2023-09-23" @default.
• W2092984904 title "Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step" @default.
• W2092984904 cites W1510879979 @default.
• W2092984904 cites W1515701659 @default.
• W2092984904 cites W1576580711 @default.
• W2092984904 cites W1583656960 @default.
• W2092984904 cites W1607671357 @default.
• W2092984904 cites W1608464482 @default.
• W2092984904 cites W1659153222 @default.
• W2092984904 cites W1666284247 @default.
• W2092984904 cites W1749755354 @default.
• W2092984904 cites W1837961456 @default.
• W2092984904 cites W1928260425 @default.
• W2092984904 cites W1967046995 @default.
• W2092984904 cites W1973627502 @default.
• W2092984904 cites W1974753375 @default.
• W2092984904 cites W1979496428 @default.
• W2092984904 cites W1989426712 @default.
• W2092984904 cites W1990799170 @default.
• W2092984904 cites W1992170822 @default.
• W2092984904 cites W1993652140 @default.
• W2092984904 cites W1998681857 @default.
• W2092984904 cites W2002927748 @default.
• W2092984904 cites W2005744880 @default.
• W2092984904 cites W2008792865 @default.
• W2092984904 cites W2011827928 @default.
• W2092984904 cites W2013542464 @default.
• W2092984904 cites W2016129100 @default.
• W2092984904 cites W2018662966 @default.
• W2092984904 cites W2021885593 @default.
• W2092984904 cites W2035550082 @default.
• W2092984904 cites W2037532701 @default.
• W2092984904 cites W2042834556 @default.
• W2092984904 cites W2044273755 @default.
• W2092984904 cites W2046909406 @default.
• W2092984904 cites W2051473177 @default.
• W2092984904 cites W2058200799 @default.
• W2092984904 cites W2063055145 @default.
• W2092984904 cites W2069336896 @default.
• W2092984904 cites W2069354675 @default.
• W2092984904 cites W2070147819 @default.
• W2092984904 cites W2077664665 @default.
• W2092984904 cites W2079651195 @default.
• W2092984904 cites W2086045560 @default.
• W2092984904 cites W2086545953 @default.
• W2092984904 cites W2087964046 @default.
• W2092984904 cites W2099814708 @default.
• W2092984904 cites W2104029934 @default.
• W2092984904 cites W2105663186 @default.
• W2092984904 cites W2106389606 @default.
• W2092984904 cites W2109851824 @default.
• W2092984904 cites W2111885726 @default.
• W2092984904 cites W2112853568 @default.
• W2092984904 cites W2114005002 @default.
• W2092984904 cites W2137701272 @default.
• W2092984904 cites W2142862020 @default.
• W2092984904 cites W216009453 @default.
• W2092984904 cites W2160769038 @default.
• W2092984904 cites W2340946024 @default.
• W2092984904 cites W2436956706 @default.
• W2092984904 cites W4300580226 @default.
• W2092984904 doi "https://doi.org/10.1016/s0306-4522(02)00797-2" @default.
• W2092984904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12573716" @default.
• W2092984904 hasPublicationYear "2003" @default.
• W2092984904 type Work @default.
• W2092984904 sameAs 2092984904 @default.
• W2092984904 citedByCount "76" @default.
• W2092984904 countsByYear W20929849042012 @default.
• W2092984904 countsByYear W20929849042013 @default.
• W2092984904 countsByYear W20929849042014 @default.
• W2092984904 countsByYear W20929849042015 @default.
• W2092984904 countsByYear W20929849042016 @default.
• W2092984904 countsByYear W20929849042017 @default.
• W2092984904 countsByYear W20929849042018 @default.
• W2092984904 countsByYear W20929849042019 @default.
• W2092984904 countsByYear W20929849042020 @default.
• W2092984904 countsByYear W20929849042021 @default.
• W2092984904 countsByYear W20929849042022 @default.
• W2092984904 countsByYear W20929849042023 @default.
• W2092984904 crossrefType "journal-article" @default.
• W2092984904 hasAuthorship W2092984904A5008354384 @default.
• W2092984904 hasAuthorship W2092984904A5032456571 @default.
• W2092984904 hasAuthorship W2092984904A5058824296 @default.
• W2092984904 hasAuthorship W2092984904A5059996026 @default.
• W2092984904 hasAuthorship W2092984904A5068972113 @default.
• W2092984904 hasConcept C104317684 @default.
• W2092984904 hasConcept C139124968 @default.
• W2092984904 hasConcept C170493617 @default.
• W2092984904 hasConcept C185592680 @default.
• W2092984904 hasConcept C25274449 @default.

• next