FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2092995930> ?p ?o ?g. }

• W2092995930 endingPage "124" @default.
• W2092995930 startingPage "118" @default.
• W2092995930 abstract "Objective We sought to identify single-nucleotide polymorphisms (SNPs) associated with Alzheimer's disease (AD) progression and brain volume. Methods Ninety-seven SNPs were genotyped in 243 subjects from a longitudinal study of healthy aging. Subjects who received a diagnosis of cognitive impairment (CI) at any study visit (before their most recent visit) and had DNA in the study's DNA bank were included. Progression of AD was defined as the duration from onset of CI to diagnosis of AD. Association of each of the 97 SNPs with AD progression was tested via Cox model. Those SNPs meeting a criterion of nominal significance (P < 0.05) for association with AD progression were reassessed to account for multiple testing by repeating the marker selection process in 10,000 random permutations. Next, the association between the one SNP that survived the multiple-testing adjustment and brain volume was determined by multiple regression analysis in a subgroup of subjects for whom magnetic-resonance imaging (MRI)-derived brain-volume data were available. Brain volumes were adjusted for age at MRI, gender, and time from MRI to onset of CI. Results The minor allele of rs1468063 in the FAS gene, which is member 6 of the tumor necrosis factor receptor superfamily, was significantly associated with faster AD progression after adjustment for multiple testing (Ppermutation = 0.049). The same allele in rs1468063 was associated with smaller brain volumes and larger ventricular volumes (P = 0.02 and 0.04, respectively). Conclusions The FAS gene, which plays a role in apoptosis, may be associated with AD by modulating the apoptosis and neuronal loss secondary to AD neuropathology." @default.
• W2092995930 created "2016-06-24" @default.
• W2092995930 creator A5004235479 @default.
• W2092995930 creator A5033146190 @default.
• W2092995930 creator A5040419704 @default.
• W2092995930 creator A5040631126 @default.
• W2092995930 creator A5076400266 @default.
• W2092995930 date "2009-09-22" @default.
• W2092995930 modified "2023-09-24" @default.
• W2092995930 title "The <i>FAS</i> gene, brain volume, and disease progression in Alzheimer's disease" @default.
• W2092995930 cites W124123819 @default.
• W2092995930 cites W1847168837 @default.
• W2092995930 cites W1966417374 @default.
• W2092995930 cites W1973792489 @default.
• W2092995930 cites W1976423935 @default.
• W2092995930 cites W1977813572 @default.
• W2092995930 cites W1980529166 @default.
• W2092995930 cites W1987469323 @default.
• W2092995930 cites W1991304383 @default.
• W2092995930 cites W1991952617 @default.
• W2092995930 cites W1999631936 @default.
• W2092995930 cites W1999840793 @default.
• W2092995930 cites W1999864873 @default.
• W2092995930 cites W2003762929 @default.
• W2092995930 cites W2006270268 @default.
• W2092995930 cites W2008352401 @default.
• W2092995930 cites W2011617651 @default.
• W2092995930 cites W2013200926 @default.
• W2092995930 cites W2017079501 @default.
• W2092995930 cites W2018360155 @default.
• W2092995930 cites W2020435508 @default.
• W2092995930 cites W2030586974 @default.
• W2092995930 cites W2033552121 @default.
• W2092995930 cites W2036362108 @default.
• W2092995930 cites W2041014331 @default.
• W2092995930 cites W2045153164 @default.
• W2092995930 cites W2045477987 @default.
• W2092995930 cites W2046209489 @default.
• W2092995930 cites W2047649942 @default.
• W2092995930 cites W2058723245 @default.
• W2092995930 cites W2063317165 @default.
• W2092995930 cites W2065279830 @default.
• W2092995930 cites W2069238604 @default.
• W2092995930 cites W2073949400 @default.
• W2092995930 cites W2082042799 @default.
• W2092995930 cites W2088519917 @default.
• W2092995930 cites W2099450592 @default.
• W2092995930 cites W2128348740 @default.
• W2092995930 cites W2130763755 @default.
• W2092995930 cites W2131242591 @default.
• W2092995930 cites W2133557496 @default.
• W2092995930 cites W2150179643 @default.
• W2092995930 cites W2154034238 @default.
• W2092995930 cites W2156220037 @default.
• W2092995930 cites W2162936584 @default.
• W2092995930 cites W2166036638 @default.
• W2092995930 cites W2166966137 @default.
• W2092995930 cites W2171998949 @default.
• W2092995930 cites W2503214490 @default.
• W2092995930 cites W4246376884 @default.
• W2092995930 doi "https://doi.org/10.1016/j.jalz.2009.05.663" @default.
• W2092995930 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3100774" @default.
• W2092995930 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19766542" @default.
• W2092995930 hasPublicationYear "2009" @default.
• W2092995930 type Work @default.
• W2092995930 sameAs 2092995930 @default.
• W2092995930 citedByCount "34" @default.
• W2092995930 countsByYear W20929959302012 @default.
• W2092995930 countsByYear W20929959302013 @default.
• W2092995930 countsByYear W20929959302014 @default.
• W2092995930 countsByYear W20929959302015 @default.
• W2092995930 countsByYear W20929959302016 @default.
• W2092995930 countsByYear W20929959302017 @default.
• W2092995930 countsByYear W20929959302018 @default.
• W2092995930 countsByYear W20929959302020 @default.
• W2092995930 countsByYear W20929959302021 @default.
• W2092995930 countsByYear W20929959302022 @default.
• W2092995930 countsByYear W20929959302023 @default.
• W2092995930 crossrefType "journal-article" @default.
• W2092995930 hasAuthorship W2092995930A5004235479 @default.
• W2092995930 hasAuthorship W2092995930A5033146190 @default.
• W2092995930 hasAuthorship W2092995930A5040419704 @default.
• W2092995930 hasAuthorship W2092995930A5040631126 @default.
• W2092995930 hasAuthorship W2092995930A5076400266 @default.
• W2092995930 hasBestOaLocation W20929959302 @default.
• W2092995930 hasConcept C104317684 @default.
• W2092995930 hasConcept C126322002 @default.
• W2092995930 hasConcept C126838900 @default.
• W2092995930 hasConcept C135763542 @default.
• W2092995930 hasConcept C139275648 @default.
• W2092995930 hasConcept C143409427 @default.
• W2092995930 hasConcept C143998085 @default.
• W2092995930 hasConcept C153209595 @default.
• W2092995930 hasConcept C157410074 @default.
• W2092995930 hasConcept C180754005 @default.
• W2092995930 hasConcept C2779134260 @default.
• W2092995930 hasConcept C50382708 @default.
• W2092995930 hasConcept C54355233 @default.

• next