FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093001303> ?p ?o ?g. }

• W2093001303 endingPage "772" @default.
• W2093001303 startingPage "765" @default.
• W2093001303 abstract "Neuropeptide Y (NPY) is widely distributed throughout the brain and has been implicated in some of the actions of ethanol. The aim of the present study was to characterize the subtypes of NPY receptors in ethanol induced sedation, tolerance and withdrawal hyper-excitability. The loss of righting reflex paradigm was used to record the sleep duration in mice. The acute administration of ethanol (3–4 g per kg, i.p., 20% v/v) resulted in marked sedation. While prolonged ethanol consumption led to the development of tolerance, the mice showed hyper-excitability following ethanol withdrawal. Prior acute intracerebroventricular (i.c.v.) injection of NPY (5–20 ng per mouse) or NPY Y1 and Y5 receptors agonist [Leu31, Pro34]-NPY (0.02–0.2 ng per mouse) potentiated ethanol induced sedation. On the other hand, administration of selective NPY Y1 receptor antagonist BIBP3226 (5 ng per mouse, i.c.v.) inhibited ethanol induced sedation. Chronic concomitant treatment of NPY (20 ng per mouse, i.c.v.) or [Leu31, Pro34]-NPY (0.2 ng per mouse, i.c.v.) to ethanol-fed groups prevented the development of tolerance and attenuated withdrawal hyper-excitability. Moreover, acute treatment of NPY (5 ng per mouse, i.c.v.) or [Leu31, Pro34]-NPY (0.02 ng per mouse, i.c.v.) reversed the peak ethanol withdrawal hyper-excitability. The results underscore a role for NPY Y1 and Y5 receptors in the ethanol induced sedation, tolerance and withdrawal hyper-excitability. We suggest that modulation of NPY Y1 and Y5 receptors may be a strategy to address the ethanol withdrawal conditions." @default.
• W2093001303 created "2016-06-24" @default.
• W2093001303 creator A5006168278 @default.
• W2093001303 creator A5009142848 @default.
• W2093001303 creator A5040276048 @default.
• W2093001303 creator A5054769053 @default.
• W2093001303 creator A5089054612 @default.
• W2093001303 date "2009-11-01" @default.
• W2093001303 modified "2023-10-16" @default.
• W2093001303 title "Tolerance to ethanol sedation and withdrawal hyper-excitability is mediated via neuropeptide Y Y1 and Y5 receptors" @default.
• W2093001303 cites W1520918304 @default.
• W2093001303 cites W1522236910 @default.
• W2093001303 cites W1537461273 @default.
• W2093001303 cites W1886452735 @default.
• W2093001303 cites W1951786929 @default.
• W2093001303 cites W1966809810 @default.
• W2093001303 cites W1968269934 @default.
• W2093001303 cites W1969649329 @default.
• W2093001303 cites W1977104619 @default.
• W2093001303 cites W1978399465 @default.
• W2093001303 cites W1980124343 @default.
• W2093001303 cites W1982070204 @default.
• W2093001303 cites W1983218339 @default.
• W2093001303 cites W1988575851 @default.
• W2093001303 cites W1988820780 @default.
• W2093001303 cites W1989416066 @default.
• W2093001303 cites W1992631900 @default.
• W2093001303 cites W1997653830 @default.
• W2093001303 cites W1997917365 @default.
• W2093001303 cites W1998130442 @default.
• W2093001303 cites W1998478663 @default.
• W2093001303 cites W1999177174 @default.
• W2093001303 cites W1999202027 @default.
• W2093001303 cites W2002829388 @default.
• W2093001303 cites W2005590048 @default.
• W2093001303 cites W2006723590 @default.
• W2093001303 cites W2006842834 @default.
• W2093001303 cites W2009286885 @default.
• W2093001303 cites W2012428426 @default.
• W2093001303 cites W2016377226 @default.
• W2093001303 cites W2017355539 @default.
• W2093001303 cites W2017763577 @default.
• W2093001303 cites W2023472271 @default.
• W2093001303 cites W2023947543 @default.
• W2093001303 cites W2027749150 @default.
• W2093001303 cites W2029837044 @default.
• W2093001303 cites W2033486196 @default.
• W2093001303 cites W2034382807 @default.
• W2093001303 cites W2038336231 @default.
• W2093001303 cites W2039424549 @default.
• W2093001303 cites W2040789109 @default.
• W2093001303 cites W2042318783 @default.
• W2093001303 cites W2043280288 @default.
• W2093001303 cites W2044655068 @default.
• W2093001303 cites W2047473676 @default.
• W2093001303 cites W2048616710 @default.
• W2093001303 cites W2049510346 @default.
• W2093001303 cites W2050844190 @default.
• W2093001303 cites W2053481535 @default.
• W2093001303 cites W2054373467 @default.
• W2093001303 cites W2055727567 @default.
• W2093001303 cites W2057305150 @default.
• W2093001303 cites W2059220098 @default.
• W2093001303 cites W2060087014 @default.
• W2093001303 cites W2062057903 @default.
• W2093001303 cites W2064883840 @default.
• W2093001303 cites W2065760031 @default.
• W2093001303 cites W2067856378 @default.
• W2093001303 cites W2069250032 @default.
• W2093001303 cites W2070681305 @default.
• W2093001303 cites W2071620003 @default.
• W2093001303 cites W2075276600 @default.
• W2093001303 cites W2081524870 @default.
• W2093001303 cites W2082370826 @default.
• W2093001303 cites W2084941560 @default.
• W2093001303 cites W2086905464 @default.
• W2093001303 cites W2091219420 @default.
• W2093001303 cites W2094399122 @default.
• W2093001303 cites W2095264825 @default.
• W2093001303 cites W2101243836 @default.
• W2093001303 cites W2101520981 @default.
• W2093001303 cites W2107548513 @default.
• W2093001303 cites W2108678409 @default.
• W2093001303 cites W2112006684 @default.
• W2093001303 cites W2119094463 @default.
• W2093001303 cites W2123784072 @default.
• W2093001303 cites W2129457454 @default.
• W2093001303 cites W2131401230 @default.
• W2093001303 cites W2133171990 @default.
• W2093001303 cites W2133550317 @default.
• W2093001303 cites W2145128242 @default.
• W2093001303 cites W2145437854 @default.
• W2093001303 cites W2145750072 @default.
• W2093001303 cites W2150413179 @default.
• W2093001303 cites W2154347093 @default.
• W2093001303 cites W2159714770 @default.
• W2093001303 cites W4239091887 @default.
• W2093001303 doi "https://doi.org/10.1016/j.lfs.2009.10.007" @default.

• next