Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093001829> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2093001829 endingPage "799" @default.
- W2093001829 startingPage "793" @default.
- W2093001829 abstract "Desensitization of the anterior pituitary has been observed after continuous infusion of LHRH or repetitive administration of LHRH at concentrations or frequencies exceeding physiological limits. We have studied the LH responsiveness of the LHRH-desensitized male rat anterior pituitary in a continuously perifused dispersed cell culture system. Infusion of 10 nM LHRH initially stimulated a 4- to 5-fold increase in LH secretion which became maximal at 6-9 min and which declined gradually to a preinfusion baseline over 6 h. Since the cells did not maintain peak levels of LH secretion in the presence of continuous exposure to LHRH, they were considered to be desensitized. These desensitized cells were studied to determine their LH responsiveness to LHRH. Cells desensitized by a 6-h LHRH infusion responded to four hourly LHRH boluses of 200 pm by releasing four statistically equal LH pulses. The response of desensitized cells to 200 pm LHRH was similar to that of 10 pm LHRH of nondesensitized cells. Furthermore, desensitized anterior pituitary cells responded to LHRH in a linear dose-dependent manner. The dose response of desensitized cells ranged from 75-500 pm, whereas for nondesensitized cells a dose response was observed from 1-75 pm. In addition, anterior pituitary cells desensitized with continuous LHRH infusion can respond to a second LHRH infusion of a greater concentration and become desensitized for a second time. These data suggest that the capacity of the pituitary gland to store and secrete LH while desensitized is similar to that of the nondesensitized anterior pituitary. The major difference between cells desensitized with LHRH and nondesensitized cells is that desensitized cells require a larger dose of LHRH to elicit a given LH response." @default.
- W2093001829 created "2016-06-24" @default.
- W2093001829 creator A5021267987 @default.
- W2093001829 creator A5076259954 @default.
- W2093001829 creator A5085548490 @default.
- W2093001829 date "1983-03-01" @default.
- W2093001829 modified "2023-09-26" @default.
- W2093001829 title "The Luteinizing Hormone-Releasing Hormone (LHRH) Desensitized Rat Pituitary: Luteinizing Hormone Responsiveness to LHRH in Vitro*" @default.
- W2093001829 cites W1981181400 @default.
- W2093001829 cites W1987241450 @default.
- W2093001829 cites W2008733524 @default.
- W2093001829 cites W2016794614 @default.
- W2093001829 cites W2018439313 @default.
- W2093001829 cites W2020625803 @default.
- W2093001829 cites W2032971632 @default.
- W2093001829 cites W2042167610 @default.
- W2093001829 cites W2058362095 @default.
- W2093001829 cites W2070999156 @default.
- W2093001829 cites W2071962891 @default.
- W2093001829 cites W2074607818 @default.
- W2093001829 cites W2077563872 @default.
- W2093001829 cites W2085289803 @default.
- W2093001829 cites W2085373050 @default.
- W2093001829 cites W2107960574 @default.
- W2093001829 cites W2129261798 @default.
- W2093001829 cites W2152717714 @default.
- W2093001829 cites W2157999228 @default.
- W2093001829 cites W2407406168 @default.
- W2093001829 cites W2410746056 @default.
- W2093001829 cites W2415692277 @default.
- W2093001829 doi "https://doi.org/10.1210/endo-112-3-793" @default.
- W2093001829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6337047" @default.
- W2093001829 hasPublicationYear "1983" @default.
- W2093001829 type Work @default.
- W2093001829 sameAs 2093001829 @default.
- W2093001829 citedByCount "66" @default.
- W2093001829 crossrefType "journal-article" @default.
- W2093001829 hasAuthorship W2093001829A5021267987 @default.
- W2093001829 hasAuthorship W2093001829A5076259954 @default.
- W2093001829 hasAuthorship W2093001829A5085548490 @default.
- W2093001829 hasConcept C126322002 @default.
- W2093001829 hasConcept C134018914 @default.
- W2093001829 hasConcept C170493617 @default.
- W2093001829 hasConcept C185592680 @default.
- W2093001829 hasConcept C197012351 @default.
- W2093001829 hasConcept C2777658017 @default.
- W2093001829 hasConcept C2778575703 @default.
- W2093001829 hasConcept C2778894405 @default.
- W2093001829 hasConcept C2779029589 @default.
- W2093001829 hasConcept C2779779143 @default.
- W2093001829 hasConcept C49039625 @default.
- W2093001829 hasConcept C56191518 @default.
- W2093001829 hasConcept C71315377 @default.
- W2093001829 hasConcept C71924100 @default.
- W2093001829 hasConcept C86803240 @default.
- W2093001829 hasConceptScore W2093001829C126322002 @default.
- W2093001829 hasConceptScore W2093001829C134018914 @default.
- W2093001829 hasConceptScore W2093001829C170493617 @default.
- W2093001829 hasConceptScore W2093001829C185592680 @default.
- W2093001829 hasConceptScore W2093001829C197012351 @default.
- W2093001829 hasConceptScore W2093001829C2777658017 @default.
- W2093001829 hasConceptScore W2093001829C2778575703 @default.
- W2093001829 hasConceptScore W2093001829C2778894405 @default.
- W2093001829 hasConceptScore W2093001829C2779029589 @default.
- W2093001829 hasConceptScore W2093001829C2779779143 @default.
- W2093001829 hasConceptScore W2093001829C49039625 @default.
- W2093001829 hasConceptScore W2093001829C56191518 @default.
- W2093001829 hasConceptScore W2093001829C71315377 @default.
- W2093001829 hasConceptScore W2093001829C71924100 @default.
- W2093001829 hasConceptScore W2093001829C86803240 @default.
- W2093001829 hasIssue "3" @default.
- W2093001829 hasLocation W20930018291 @default.
- W2093001829 hasLocation W20930018292 @default.
- W2093001829 hasOpenAccess W2093001829 @default.
- W2093001829 hasPrimaryLocation W20930018291 @default.
- W2093001829 hasRelatedWork W1986415250 @default.
- W2093001829 hasRelatedWork W2024553435 @default.
- W2093001829 hasRelatedWork W2033315361 @default.
- W2093001829 hasRelatedWork W2033525217 @default.
- W2093001829 hasRelatedWork W2035274793 @default.
- W2093001829 hasRelatedWork W2055041622 @default.
- W2093001829 hasRelatedWork W2071237287 @default.
- W2093001829 hasRelatedWork W2079195384 @default.
- W2093001829 hasRelatedWork W2093001829 @default.
- W2093001829 hasRelatedWork W2141504910 @default.
- W2093001829 hasVolume "112" @default.
- W2093001829 isParatext "false" @default.
- W2093001829 isRetracted "false" @default.
- W2093001829 magId "2093001829" @default.
- W2093001829 workType "article" @default.