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- W2093003148 abstract "Head and neck squamous cell carcinoma represents a complex set of neoplasms arising in diverse anatomical locations. The site and stage of the cancer determine whether patients will be treated with single or multi-modality therapy. The HDAC inhibitor LBH589 is effective in treating some haematological neoplasms and shows promise for certain epithelial neoplasms. As with other human cancer cell lines, LBH589 causes up-regulation of p21, G2/M cell cycle arrest, and cell death of human HNSCC cell lines, as measured using flow cytometry and cDNA microarrays. Global RNA expression studies following treatment of the HNSCC cell line FaDu with LBH589 reveal down-regulation of genes required for chromosome congression and segregation (SMC2L1), sister chromatid cohesion (DDX11), and kinetochore structure (CENP-A, CENP-F, and CENP-M); these LBH589-induced changes in gene expression coupled with the down-regulation of MYC and BIRC5 (survivin) provide a plausible explanation for the early mitotic arrest and cell death observed. When LBH589-induced changes in gene expression were compared with gene expression profiles of 41 primary HNSCC samples, many of the genes that were down-regulated by LBH589 showed increased expression in primary HNSCC, suggesting that some patients with HNSCC may respond to treatment with LBH589. Copyright © 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd." @default.
- W2093003148 created "2016-06-24" @default.
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- W2093003148 date "2009-08-01" @default.
- W2093003148 modified "2023-10-13" @default.
- W2093003148 title "The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines" @default.
- W2093003148 cites W1502418486 @default.
- W2093003148 cites W1513329088 @default.
- W2093003148 cites W1817917437 @default.
- W2093003148 cites W194837403 @default.
- W2093003148 cites W1974244352 @default.
- W2093003148 cites W1975089320 @default.
- W2093003148 cites W1976298557 @default.
- W2093003148 cites W1986364710 @default.
- W2093003148 cites W1987898954 @default.
- W2093003148 cites W1989582949 @default.
- W2093003148 cites W1992321269 @default.
- W2093003148 cites W1994211401 @default.
- W2093003148 cites W1996103159 @default.
- W2093003148 cites W2001218098 @default.
- W2093003148 cites W2002125670 @default.
- W2093003148 cites W2002698073 @default.
- W2093003148 cites W2013919679 @default.
- W2093003148 cites W2015851881 @default.
- W2093003148 cites W2019918282 @default.
- W2093003148 cites W2020411912 @default.
- W2093003148 cites W2023695022 @default.
- W2093003148 cites W2025669923 @default.
- W2093003148 cites W2029524330 @default.
- W2093003148 cites W2029875848 @default.
- W2093003148 cites W2030320771 @default.
- W2093003148 cites W2033457416 @default.
- W2093003148 cites W2036256995 @default.
- W2093003148 cites W2038266181 @default.
- W2093003148 cites W2038466533 @default.
- W2093003148 cites W2041027497 @default.
- W2093003148 cites W2043260970 @default.
- W2093003148 cites W2054724044 @default.
- W2093003148 cites W2055993339 @default.
- W2093003148 cites W2056209423 @default.
- W2093003148 cites W2056561005 @default.
- W2093003148 cites W2058023641 @default.
- W2093003148 cites W2058943350 @default.
- W2093003148 cites W2062072040 @default.
- W2093003148 cites W2062084817 @default.
- W2093003148 cites W2064810566 @default.
- W2093003148 cites W2066264051 @default.
- W2093003148 cites W2067535345 @default.
- W2093003148 cites W2073052482 @default.
- W2093003148 cites W2074245850 @default.
- W2093003148 cites W2075468442 @default.
- W2093003148 cites W2078500792 @default.
- W2093003148 cites W2078794379 @default.
- W2093003148 cites W2080125477 @default.
- W2093003148 cites W2082259697 @default.
- W2093003148 cites W2083175994 @default.
- W2093003148 cites W2086152873 @default.
- W2093003148 cites W2086703813 @default.
- W2093003148 cites W2086743941 @default.
- W2093003148 cites W2088406768 @default.
- W2093003148 cites W2088624336 @default.
- W2093003148 cites W2089193589 @default.
- W2093003148 cites W2089844705 @default.
- W2093003148 cites W2090272354 @default.
- W2093003148 cites W2091381212 @default.
- W2093003148 cites W2097537611 @default.
- W2093003148 cites W2097973787 @default.
- W2093003148 cites W2099803844 @default.
- W2093003148 cites W2100961085 @default.
- W2093003148 cites W2100972878 @default.
- W2093003148 cites W2103703088 @default.
- W2093003148 cites W2104337841 @default.
- W2093003148 cites W2106839967 @default.
- W2093003148 cites W2107263674 @default.
- W2093003148 cites W2107277218 @default.
- W2093003148 cites W2107424534 @default.
- W2093003148 cites W2110358014 @default.
- W2093003148 cites W2111868018 @default.
- W2093003148 cites W2112555367 @default.
- W2093003148 cites W2113634596 @default.
- W2093003148 cites W2120068217 @default.
- W2093003148 cites W2121167030 @default.
- W2093003148 cites W2121619780 @default.
- W2093003148 cites W2124492056 @default.
- W2093003148 cites W2125306062 @default.
- W2093003148 cites W2125917346 @default.
- W2093003148 cites W2126683450 @default.
- W2093003148 cites W2126860097 @default.