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- W2093011489 abstract "Objective – Single nucleotide polymorphisms in the regulatory regions of the cytokine genes for tumor necrosis factor α (TNFα), interleukin (IL)-6 and IL-10 have been suggested to influence the risk of Alzheimer’s disease (AD) with conflicting results. Aim – To investigate the TNFα–308, IL-6 –174 and IL-10 –1082 gene polymorphisms as susceptibility factors for AD. Methods – We analyzed genotype and allele distributions of these polymorphisms in 101 sporadic AD patients and 138 healthy controls. Results – Heterozygotes (AG) or combined genotype (AG+AA) for IL-10 –1082 were associated with approximately two-fold increase in the risk of AD. Carriers of A alleles of both TNFα–308 and IL-10 –1082 had 6.5 times higher risk for AD in comparison with non-carriers. Concomitant presence of both mutant TNFα–308 A and IL-6 –174 C alleles raised three-fold the AD risk, whereas there was no notable risk for AD afflicted by IL-6 –174 polymorphism alone. Conclusion – Our results suggest that TNFα and IL-10 promoter polymorphism might be a risk factor for AD. The combined effects of TNFα–308, IL-6 –174 and IL-10 –1082 variant alleles may be more decisive to induce functional differences and modify the risk for AD." @default.
- W2093011489 created "2016-06-24" @default.
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- W2093011489 date "2009-09-10" @default.
- W2093011489 modified "2023-10-18" @default.
- W2093011489 title "The combinations of TNFα-308 and IL-6 -174 or IL-10 -1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer’s disease" @default.
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- W2093011489 doi "https://doi.org/10.1111/j.1600-0404.2009.01230.x" @default.
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