FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093014473> ?p ?o ?g. }

• W2093014473 endingPage "888" @default.
• W2093014473 startingPage "879" @default.
• W2093014473 abstract "T-type Ca2+ channel current (ICa,T) plays an important role for spontaneous pacemaker activity and is involved in the progression of structural heart diseases. Estrogens are of importance for the regulation of growth and differentiation and function in a wide array of target tissues, including those in the cardiovascular system. The aim of this study was to elucidate the short-term and long-term effects of 17β-estradiol (E2) on ICa,T in cardiomyocytes. We employed in vivo and in vitro techniques to clarify E2-mediated modulation of heart rate (HR) in ovariectomized rats and ICa,T in cardiomyocytes. Ovariectomy increased HR and E2 supplement reduced HR in ovariectomized rats. Slowing of E2-induced HR was consistent with the deceleration of automaticity in E2-treated neonatal cardiomyocytes. Short-term application of E2 did not have significant effects on ICa,T, whereas in cardiomyocytes treated with 10 nm E2 for 24 h, estrogen receptor-independent down-regulation of peak ICa,T and declination of CaV3.2 mRNA were observed. Expression of a cardiac-specific transcription factor Csx/Nkx2.5 was also suppressed by E2 treatment for 24 h. On the other hand, expression of CaV3.1 mRNA was unaltered by E2 treatment in this study. An ERK-1/2, 5 inhibitor, PD-98059, abolished the effects of E2 on ICa,T and CaV3.2 mRNA as well as Csx/Nkx2.5 mRNA. These findings indicate that E2 decreases CaV3.2 ICa,T through activation of ERK-1/2, 5, which is mediated by the suppression of Csx/Nkx2.5-dependent transcription, suggesting a genomic effect of E2 as a negative chronotropic factor in the heart. Long-term treatment of cardiomyocytes with 17β-estradiol decreases the T-type Ca2+ channel current of CaV3.2 through activation of ERK-1/2, 5, which is mediated by the suppression of a transcription factor Csx/Nkx2.5." @default.
• W2093014473 created "2016-06-24" @default.
• W2093014473 creator A5003642180 @default.
• W2093014473 creator A5017890368 @default.
• W2093014473 creator A5021592390 @default.
• W2093014473 creator A5024744991 @default.
• W2093014473 creator A5079938599 @default.
• W2093014473 creator A5084195189 @default.
• W2093014473 creator A5007542960 @default.
• W2093014473 creator A5009650793 @default.
• W2093014473 date "2009-02-01" @default.
• W2093014473 modified "2023-10-17" @default.
• W2093014473 title "17β-Estradiol Modulates Expression of Low-Voltage-Activated CaV3.2 T-Type Calcium Channel via Extracellularly Regulated Kinase Pathway in Cardiomyocytes" @default.
• W2093014473 cites W1520650580 @default.
• W2093014473 cites W1558176436 @default.
• W2093014473 cites W1564796335 @default.
• W2093014473 cites W1973799408 @default.
• W2093014473 cites W1977892849 @default.
• W2093014473 cites W1979639957 @default.
• W2093014473 cites W1981301512 @default.
• W2093014473 cites W1982836201 @default.
• W2093014473 cites W1985506908 @default.
• W2093014473 cites W1987014317 @default.
• W2093014473 cites W1987416588 @default.
• W2093014473 cites W1987837483 @default.
• W2093014473 cites W1989810511 @default.
• W2093014473 cites W1990374532 @default.
• W2093014473 cites W1995223011 @default.
• W2093014473 cites W2005264220 @default.
• W2093014473 cites W2006862162 @default.
• W2093014473 cites W2012561790 @default.
• W2093014473 cites W2012791105 @default.
• W2093014473 cites W2015878560 @default.
• W2093014473 cites W2016841050 @default.
• W2093014473 cites W2017661666 @default.
• W2093014473 cites W2021110709 @default.
• W2093014473 cites W2031195896 @default.
• W2093014473 cites W2041526045 @default.
• W2093014473 cites W2048671549 @default.
• W2093014473 cites W2051842115 @default.
• W2093014473 cites W2054267961 @default.
• W2093014473 cites W2054913890 @default.
• W2093014473 cites W2057103859 @default.
• W2093014473 cites W2062504645 @default.
• W2093014473 cites W2064182380 @default.
• W2093014473 cites W2071492647 @default.
• W2093014473 cites W2072378777 @default.
• W2093014473 cites W2072621146 @default.
• W2093014473 cites W2074102566 @default.
• W2093014473 cites W2082470387 @default.
• W2093014473 cites W2083681760 @default.
• W2093014473 cites W2091690694 @default.
• W2093014473 cites W2093388887 @default.
• W2093014473 cites W2093676604 @default.
• W2093014473 cites W2094096789 @default.
• W2093014473 cites W2114936393 @default.
• W2093014473 cites W2131170556 @default.
• W2093014473 cites W2135372958 @default.
• W2093014473 cites W2135480559 @default.
• W2093014473 cites W2136070250 @default.
• W2093014473 cites W2137470139 @default.
• W2093014473 cites W2137693602 @default.
• W2093014473 cites W2142772417 @default.
• W2093014473 cites W2148336522 @default.
• W2093014473 cites W2150116795 @default.
• W2093014473 cites W2150583813 @default.
• W2093014473 cites W2155975969 @default.
• W2093014473 cites W2157796632 @default.
• W2093014473 cites W2169122898 @default.
• W2093014473 cites W2171830917 @default.
• W2093014473 doi "https://doi.org/10.1210/en.2008-0645" @default.
• W2093014473 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18832095" @default.
• W2093014473 hasPublicationYear "2009" @default.
• W2093014473 type Work @default.
• W2093014473 sameAs 2093014473 @default.
• W2093014473 citedByCount "33" @default.
• W2093014473 countsByYear W20930144732012 @default.
• W2093014473 countsByYear W20930144732013 @default.
• W2093014473 countsByYear W20930144732014 @default.
• W2093014473 countsByYear W20930144732015 @default.
• W2093014473 countsByYear W20930144732016 @default.
• W2093014473 countsByYear W20930144732017 @default.
• W2093014473 countsByYear W20930144732019 @default.
• W2093014473 countsByYear W20930144732020 @default.
• W2093014473 countsByYear W20930144732021 @default.
• W2093014473 countsByYear W20930144732022 @default.
• W2093014473 countsByYear W20930144732023 @default.
• W2093014473 crossrefType "journal-article" @default.
• W2093014473 hasAuthorship W2093014473A5003642180 @default.
• W2093014473 hasAuthorship W2093014473A5007542960 @default.
• W2093014473 hasAuthorship W2093014473A5009650793 @default.
• W2093014473 hasAuthorship W2093014473A5017890368 @default.
• W2093014473 hasAuthorship W2093014473A5021592390 @default.
• W2093014473 hasAuthorship W2093014473A5024744991 @default.
• W2093014473 hasAuthorship W2093014473A5079938599 @default.
• W2093014473 hasAuthorship W2093014473A5084195189 @default.
• W2093014473 hasBestOaLocation W20930144731 @default.
• W2093014473 hasConcept C104317684 @default.

• next