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- W2093015099 abstract "Hematopoiesis has long served as a paradigm of stem cell biology and tissue homeostasis. In the past decade, the genomics revolution has ushered in powerful new methods for investigating the hematopoietic system that have provided transformative insights into its biology. As part of the advances in genomics, increasingly accurate deep sequencing and novel methods of cell tracking have revealed hematopoiesis to be more of a continuous and less of a discrete and punctuated process than originally envisioned. In part, this continuous nature of hematopoiesis is made possible by the emergent outcomes of vast, interconnected regulatory networks that influence cell fates and lineage commitment. It is also becoming clear how these mechanisms are modulated by genetic variation present throughout the population. This review describes how these recently uncovered complexities are reshaping our concept of tissue development and homeostasis while opening up a more comprehensive future understanding of hematopoiesis." @default.
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- W2093015099 date "2011-09-01" @default.
- W2093015099 modified "2023-09-26" @default.
- W2093015099 title "Disturbance of reaching-grasping induced by the pathway-specific blockade of the signal transmission through the mid-cervical propriospinal neurons in macaque monkeys" @default.
- W2093015099 doi "https://doi.org/10.1016/j.neures.2011.07.426" @default.
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