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• W2093022381 endingPage "146" @default.
• W2093022381 startingPage "131" @default.
• W2093022381 abstract "Background: We have shown in FG pancreatic cancer cells that α2β1 integrin-mediated type I collagen adhesion decreases parathyroid hormone-related protein (PTHrP), inerleukin-6 (IL-6), and interleukin-8 (IL-8) expression, decreases the localization of E-cadherin and β-catenin in cell-cell contacts, increases cell migration, and increases glycogen synthase kinase 3 (GSK3) and protein kinase B (PKB/Akt) phosphorylation states relative to α5β1 integrin-mediated fibronectin (Fn) adhesion. Aim of the Study: To extend our observations in FG cells to other pancreatic cancer cell lines, and to determine whether E-cadherin-mediated cell-cell adhesion and its downstream effectors were functionally involved in the ECM-mediated regulation of PTHrP, IL-6, and IL-8. Methods: We used standard biochemical techniques to determine ECM-specific differences in E-cadherin and β-catenin localization, GSK3 and PKB/Akt phosphorylation, haptokinetic cell migration, and cytokine expression in pancreatic cancer cells. We also conducted functional studies using pharmacological inhibitors for GSK3 and PKB/Akt, as well as elevated Mg2+/Ca2+ ratios similar to pancreatic juice, and examined their effects on cytokine expression. Results: Differences in E-cadherin and β-catenin localization along with GSK3 and PKB/Akt phosphorylation occur in multiple pancreatic cancer cell lines, resulting in differences in ECM-mediated haptokinesis and cytokine expression that are generally consistent with previous observations in FG cells. Our functional studies also suggest that E-cadherin-mediated cell-cell adhesion and downstream effectors are involved in PTHrP, IL-6, and IL-8 expression. Conclusions: These data indicate that α2β1 integrin-mediated type I collagen adhesion disrupts cell-cell adhesion architecture, resulting in increased migration and decreased PTHrP, IL-6, and IL-8 expression in pancreatic cancer cells." @default.
• W2093022381 created "2016-06-24" @default.
• W2093022381 creator A5004495121 @default.
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• W2093022381 date "2005-01-01" @default.
• W2093022381 modified "2023-09-23" @default.
• W2093022381 title "Type I Collagen and Divalent Cation Shifts Disrupt Cell-Cell Adhesion, Increase Migration, and Decrease PTHrP, IL-6, and IL-8 Expression in Pancreatic Cancer Cells" @default.
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• W2093022381 doi "https://doi.org/10.1385/ijgc:36:3:131" @default.
• W2093022381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16720909" @default.
• W2093022381 hasPublicationYear "2005" @default.
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