Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093025821> ?p ?o ?g. }
- W2093025821 endingPage "198" @default.
- W2093025821 startingPage "193" @default.
- W2093025821 abstract "De novo pyrimidine synthesis was studied in mouse liver, intestine, and kidney by intraperitoneal infusion of 15NH4C1 and analysis of 15N incorporation into uracil nucleotide pools. When the dose of a 1-h infusion of 15NH4C1 was increased from 50 μmol to 250 μmol the fraction of the total uracil nucleotide pool formed by de novo synthesis increased 4.0-fold in liver to 8.4% and 2.3-fold in intestine to 13.7%. The increase in intestine was independent of the increase in liver as evidenced by the lack of correlation between the increase observed in the intestine and liver of the same animal and the different distributions of label in the uracil ring nitrogens. A 2.4-fold increase in newly formed uracil nucleotides was observed in kidney when the infusion dose was raised from 150 μmol to 250 μmol. The increase in kidney was correlated with the increase in liver in the same animal and the distribution of label in the uracil ring nitrogens was similar to the distribution in liver. These results suggest that the increase in newly formed uracil nucleotides in intestine is due to increased de novo synthesis of pyrimidines in the intestine, while the increase in the kidney is due to increased salvage synthesis of uracil nucleotides from uridine synthesized in the liver and output to the circulation." @default.
- W2093025821 created "2016-06-24" @default.
- W2093025821 creator A5010900558 @default.
- W2093025821 creator A5029484897 @default.
- W2093025821 creator A5034427633 @default.
- W2093025821 creator A5052615872 @default.
- W2093025821 creator A5061737472 @default.
- W2093025821 date "1988-07-01" @default.
- W2093025821 modified "2023-09-27" @default.
- W2093025821 title "Stimulation of uracil nucleotide synthesis in mouse liver, intestine and kidney by ammonium chloride infusion" @default.
- W2093025821 cites W1493532528 @default.
- W2093025821 cites W1524995373 @default.
- W2093025821 cites W1580729290 @default.
- W2093025821 cites W1583278020 @default.
- W2093025821 cites W1583842568 @default.
- W2093025821 cites W1592565027 @default.
- W2093025821 cites W1865288239 @default.
- W2093025821 cites W1979560300 @default.
- W2093025821 cites W1983423591 @default.
- W2093025821 cites W1985000690 @default.
- W2093025821 cites W1989440391 @default.
- W2093025821 cites W1996069919 @default.
- W2093025821 cites W2024695279 @default.
- W2093025821 cites W2034927568 @default.
- W2093025821 cites W2049959041 @default.
- W2093025821 cites W2056543103 @default.
- W2093025821 cites W2067328026 @default.
- W2093025821 cites W2085941310 @default.
- W2093025821 cites W2088210473 @default.
- W2093025821 cites W2092724327 @default.
- W2093025821 cites W2094074402 @default.
- W2093025821 cites W2096725836 @default.
- W2093025821 cites W2145838771 @default.
- W2093025821 cites W2173108077 @default.
- W2093025821 cites W2206838131 @default.
- W2093025821 cites W2325889129 @default.
- W2093025821 cites W2418959378 @default.
- W2093025821 doi "https://doi.org/10.1111/j.1432-1033.1988.tb14183.x" @default.
- W2093025821 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3402448" @default.
- W2093025821 hasPublicationYear "1988" @default.
- W2093025821 type Work @default.
- W2093025821 sameAs 2093025821 @default.
- W2093025821 citedByCount "10" @default.
- W2093025821 countsByYear W20930258212015 @default.
- W2093025821 crossrefType "journal-article" @default.
- W2093025821 hasAuthorship W2093025821A5010900558 @default.
- W2093025821 hasAuthorship W2093025821A5029484897 @default.
- W2093025821 hasAuthorship W2093025821A5034427633 @default.
- W2093025821 hasAuthorship W2093025821A5052615872 @default.
- W2093025821 hasAuthorship W2093025821A5061737472 @default.
- W2093025821 hasBestOaLocation W20930258211 @default.
- W2093025821 hasConcept C104317684 @default.
- W2093025821 hasConcept C126322002 @default.
- W2093025821 hasConcept C134018914 @default.
- W2093025821 hasConcept C185592680 @default.
- W2093025821 hasConcept C2777882243 @default.
- W2093025821 hasConcept C2779321679 @default.
- W2093025821 hasConcept C2779554091 @default.
- W2093025821 hasConcept C2780091579 @default.
- W2093025821 hasConcept C2781259782 @default.
- W2093025821 hasConcept C512185932 @default.
- W2093025821 hasConcept C552990157 @default.
- W2093025821 hasConcept C55493867 @default.
- W2093025821 hasConcept C67705224 @default.
- W2093025821 hasConcept C71924100 @default.
- W2093025821 hasConcept C86803240 @default.
- W2093025821 hasConceptScore W2093025821C104317684 @default.
- W2093025821 hasConceptScore W2093025821C126322002 @default.
- W2093025821 hasConceptScore W2093025821C134018914 @default.
- W2093025821 hasConceptScore W2093025821C185592680 @default.
- W2093025821 hasConceptScore W2093025821C2777882243 @default.
- W2093025821 hasConceptScore W2093025821C2779321679 @default.
- W2093025821 hasConceptScore W2093025821C2779554091 @default.
- W2093025821 hasConceptScore W2093025821C2780091579 @default.
- W2093025821 hasConceptScore W2093025821C2781259782 @default.
- W2093025821 hasConceptScore W2093025821C512185932 @default.
- W2093025821 hasConceptScore W2093025821C552990157 @default.
- W2093025821 hasConceptScore W2093025821C55493867 @default.
- W2093025821 hasConceptScore W2093025821C67705224 @default.
- W2093025821 hasConceptScore W2093025821C71924100 @default.
- W2093025821 hasConceptScore W2093025821C86803240 @default.
- W2093025821 hasIssue "1" @default.
- W2093025821 hasLocation W20930258211 @default.
- W2093025821 hasLocation W20930258212 @default.
- W2093025821 hasOpenAccess W2093025821 @default.
- W2093025821 hasPrimaryLocation W20930258211 @default.
- W2093025821 hasRelatedWork W1970425639 @default.
- W2093025821 hasRelatedWork W1985754489 @default.
- W2093025821 hasRelatedWork W2049391750 @default.
- W2093025821 hasRelatedWork W2053676465 @default.
- W2093025821 hasRelatedWork W2083724568 @default.
- W2093025821 hasRelatedWork W2093025821 @default.
- W2093025821 hasRelatedWork W2344696941 @default.
- W2093025821 hasRelatedWork W2408937020 @default.
- W2093025821 hasRelatedWork W2427172417 @default.
- W2093025821 hasRelatedWork W2951241535 @default.
- W2093025821 hasVolume "175" @default.
- W2093025821 isParatext "false" @default.