Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093032008> ?p ?o ?g. }
- W2093032008 abstract "E-cadherin (E-cad) is the main component of epithelial junctions in multicellular organisms, where it is essential for cell-cell adhesion. The localisation of E-cad is often strongly polarised in the apico-basal axis. However, the mechanisms required for its polarised distribution are still largely unknown. We performed a systematic RNAi screen in vivo to identify genes required for the strict E-cad apical localisation in C. elegans epithelial epidermal cells. We found that the loss of clathrin, its adaptor AP-1 and the AP-1 interactor SOAP-1 induced a basolateral localisation of E-cad without affecting the apico-basal diffusion barrier. We further found that SOAP-1 controls AP-1 localisation, and that AP-1 is required for clathrin recruitment. Finally, we also show that AP-1 controls E-cad apical delivery and actin organisation during embryonic elongation, the final morphogenetic step of embryogenesis. We therefore propose that a molecular pathway, containing SOAP-1, AP-1 and clathrin, controls the apical delivery of E-cad and morphogenesis." @default.
- W2093032008 created "2016-06-24" @default.
- W2093032008 creator A5000911565 @default.
- W2093032008 creator A5026104353 @default.
- W2093032008 creator A5034404301 @default.
- W2093032008 creator A5061190003 @default.
- W2093032008 creator A5068876941 @default.
- W2093032008 creator A5083599094 @default.
- W2093032008 date "2015-01-01" @default.
- W2093032008 modified "2023-09-30" @default.
- W2093032008 title "Control of E-cadherin apical localisation and morphogenesis by a SOAP-1/AP-1/clathrin pathway in <i>C. elegans</i> epidermal cells" @default.
- W2093032008 cites W1647075334 @default.
- W2093032008 cites W191916476 @default.
- W2093032008 cites W1944127002 @default.
- W2093032008 cites W1969417219 @default.
- W2093032008 cites W1970035510 @default.
- W2093032008 cites W1975338046 @default.
- W2093032008 cites W1984024996 @default.
- W2093032008 cites W1986665005 @default.
- W2093032008 cites W1989903749 @default.
- W2093032008 cites W2001611897 @default.
- W2093032008 cites W2004863382 @default.
- W2093032008 cites W2008273587 @default.
- W2093032008 cites W2011974546 @default.
- W2093032008 cites W2015347111 @default.
- W2093032008 cites W2015468345 @default.
- W2093032008 cites W2019308540 @default.
- W2093032008 cites W2029873308 @default.
- W2093032008 cites W2031407476 @default.
- W2093032008 cites W2036180977 @default.
- W2093032008 cites W2036451831 @default.
- W2093032008 cites W2041275216 @default.
- W2093032008 cites W2051432574 @default.
- W2093032008 cites W2052072695 @default.
- W2093032008 cites W2056565217 @default.
- W2093032008 cites W2060328732 @default.
- W2093032008 cites W2061228001 @default.
- W2093032008 cites W2063591374 @default.
- W2093032008 cites W2066012475 @default.
- W2093032008 cites W2068436424 @default.
- W2093032008 cites W2073038040 @default.
- W2093032008 cites W2083970667 @default.
- W2093032008 cites W2085852911 @default.
- W2093032008 cites W2090347885 @default.
- W2093032008 cites W2094803625 @default.
- W2093032008 cites W2095261440 @default.
- W2093032008 cites W2095785516 @default.
- W2093032008 cites W2096415418 @default.
- W2093032008 cites W2101925501 @default.
- W2093032008 cites W2106555469 @default.
- W2093032008 cites W2109791816 @default.
- W2093032008 cites W2110779290 @default.
- W2093032008 cites W2113936637 @default.
- W2093032008 cites W2118548448 @default.
- W2093032008 cites W2121621688 @default.
- W2093032008 cites W2124260943 @default.
- W2093032008 cites W2124373678 @default.
- W2093032008 cites W2124733101 @default.
- W2093032008 cites W2126733007 @default.
- W2093032008 cites W2127681818 @default.
- W2093032008 cites W2129018625 @default.
- W2093032008 cites W2129460080 @default.
- W2093032008 cites W2133956002 @default.
- W2093032008 cites W2134427448 @default.
- W2093032008 cites W2134487528 @default.
- W2093032008 cites W2144282284 @default.
- W2093032008 cites W2145294610 @default.
- W2093032008 cites W2147822621 @default.
- W2093032008 cites W2148277919 @default.
- W2093032008 cites W2152401277 @default.
- W2093032008 cites W2152456282 @default.
- W2093032008 cites W2155443081 @default.
- W2093032008 cites W2165435692 @default.
- W2093032008 cites W2167279371 @default.
- W2093032008 cites W2169621308 @default.
- W2093032008 doi "https://doi.org/10.1242/dev.118216" @default.
- W2093032008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25858456" @default.
- W2093032008 hasPublicationYear "2015" @default.
- W2093032008 type Work @default.
- W2093032008 sameAs 2093032008 @default.
- W2093032008 citedByCount "36" @default.
- W2093032008 countsByYear W20930320082015 @default.
- W2093032008 countsByYear W20930320082016 @default.
- W2093032008 countsByYear W20930320082017 @default.
- W2093032008 countsByYear W20930320082018 @default.
- W2093032008 countsByYear W20930320082019 @default.
- W2093032008 countsByYear W20930320082020 @default.
- W2093032008 countsByYear W20930320082021 @default.
- W2093032008 countsByYear W20930320082022 @default.
- W2093032008 countsByYear W20930320082023 @default.
- W2093032008 crossrefType "journal-article" @default.
- W2093032008 hasAuthorship W2093032008A5000911565 @default.
- W2093032008 hasAuthorship W2093032008A5026104353 @default.
- W2093032008 hasAuthorship W2093032008A5034404301 @default.
- W2093032008 hasAuthorship W2093032008A5061190003 @default.
- W2093032008 hasAuthorship W2093032008A5068876941 @default.
- W2093032008 hasAuthorship W2093032008A5083599094 @default.
- W2093032008 hasBestOaLocation W20930320081 @default.
- W2093032008 hasConcept C104317684 @default.
- W2093032008 hasConcept C1491633281 @default.