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- W2093036489 abstract "AbstractNumerous tests, both invasive and non-invasive, are available for the diagnosis of Helicobacter pylori infection. The aim of this study was to evaluate the extent and determinants of differences in serology and 13 C-urea breath test ( 13 C-UBT ) in diagnosing H. pylori . Four-hundred-and-seventy-four asymptomatic blood donors aged 40 to 68 years (mean age 55.8 years) and of German nationality were recruited between October 1996 and November 1997. H. pylori infection was measured with 13 C-UBT and with a commercial IgG-ELISA test (Medac; Hamburg, Germany). A standardized questionnaire was applied to identify factors which could explain discrepant results of 13 C-UBT and serology. Prevalence of infection was similar according to both tests (33.1% for 13 C-UBT and 30.8 % for serology). From the 146 subjects with a positive serology, 121 (82.7%) had a positive 13 C-UBT. Previous treatment of H. pylori infection was the strongest predictor of a negative 13 C-UBT given positive IgG serology (odds ratio (OR) = 12.87, 95% CI = 4.10-40.36). Coffee consumption of more than 3 cups/day was also associated with an increased odds of a negative serology (OR = 3.12, 95% CI = 1.16-8.43). No significant determinants of positive 13 C-UBT given negative serology could be identified. These findings suggest a delayed fall in serum antibodies following eradication of the infection to be a major source of differences in H. pylori diagnosis using non invasive 13 C-UBT and serology.KeywordsCoffee Consumption H. Pylori Diagnosis Life Style Non-INVASIVE" @default.
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- W2093036489 date "2001-01-01" @default.
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- W2093036489 title "Characteristics of differences in Helicobacter pylori serology and 13 C-urea breath-testing in an asymptomatic sample of blood donors" @default.
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- W2093036489 doi "https://doi.org/10.1080/003655101753267955" @default.
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