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• W2093049817 abstract "Backgound Gastroesophageal reflux disease patients demonstrate various pathophysiologic backgrounds. Therefore, a heterogeneous response to proton-pump inhibitor (PPI) treatment can be expected. We investigated the effect of short-term PPI treatment on symptoms and quality of life (QOL) in primary care patients with and without pathologic esophageal acid exposure and in presence or absence of a positive association between symptoms and reflux episodes. Study Seventy-four heartburn patients were categorized into 4 groups according to positive or negative symptom-reflux association, as expressed in symptom index, symptom sensitivity index, and symptom association probability (SAP) and presence or absence of pathologic reflux, defined as esophageal pH<4%>6% of the time (pH+/pH−). Overall and specific reflux symptoms were assessed 1 week before and the last week during a 2-week course of 40-mg esomeprazole daily. The QOL was scored by the Quality of Life in Reflux and Dyspepsia questionnaire 2 weeks before treatment and directly after. Results Using the SAP to assess symptom-reflux associations, the 4 groups [SAP+pH+(n=40); SAP+pH−(n=12); SAP−pH+(n=10); SAP−pH−(n=10)] had similar demographic characteristics. The SAP−pH− subgroup had the least overall symptom reduction (P<0.01) and in the SAP+pH+ subgroup the greatest heartburn symptom reduction was found (P<0.02). The residual symptom scores on treatment were lowest in SAP+pH+ and highest in SAP−pH− subgroups and relatively high in the SAP+pH−. QOL was severely reduced and SAP−pH− patients had the lowest QOL overall. Similar findings were made using symptom index and symptom sensitivity index. Conclusions Symptomatic reflux patients without evidence of reflux disease on a 24-hour pH recording responded less favorably to PPI treatment than patients with a positive symptom-reflux association or with pathologic reflux." @default.
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• W2093049817 date "2008-05-01" @default.
• W2093049817 modified "2023-10-13" @default.
• W2093049817 title "Effect of Proton-Pump Inhibitor Treatment on Symptoms and Quality of Life in GERD Patients Depends on the Symptom-reflux Association" @default.
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• W2093049817 doi "https://doi.org/10.1097/mcg.0b013e318074dd62" @default.
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