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- W2093056056 abstract "Hemopoietic reconstitution of supralethally irradiated adult dogs of the Cooperstown colony with their own stored bone marrow can produce long-term unresponsiveness to DLA-identical kidney allografts with no need for any additional immunosuppression. Eleven of 18 kidneys transplanted 12 hr after replacement of autologous marrow into irradiated recipients currently survive with normal function for as long as 1,417 days; 8 of 13 organs transplanted 28 hr after marrow replacement, and 8 of 13 organs transplanted 36 hr after marrow injection, currently survive up to 502 days, with no further treatment. Alterations in the timing and sequence of each procedure decrease the incidence of unresponsiveness. Implantation of kidney allografts 20 hr before removal of marrow, followed by irradiation and marrow reconstitution produced unresponsiveness in only 3 of 21 dogs. Kidneys transplanted at the time of marrow replacement were tolerated in 4 of 16 irradiated recipients. When kidneys were placed into irradiated dogs, and an interval of 40 hr was provided before marrow reconstitution, only 5 of 19 animals became unresponsive. Twelve dogs unresponsive to renal allografts received skin grafts from the respective kidney donors. Five dogs were unresponsive to such skin allografts; the remaining seven dogs rejected the skin grafts within 115 days. Second-, third-, and fourth-set skin grafts from the kidney donor were rejected in a progressively more rapid fashion. Survival and function of the kidney allografts were not affected by the rejection of successive skin grafts from the kidney donor. Skin grafts from other DLA-identical donors and DLA-incompatible skin grafts were rejected by the same recipients in uniform fashion." @default.
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- W2093056056 date "1980-07-01" @default.
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- W2093056056 title "SPECIFIC ALLOGENEIC UNRESPONSIVENESS IN IRRADIATED DOGS RECONSTITUTED WITH AUTOLOGOUS BONE MARROW" @default.
- W2093056056 doi "https://doi.org/10.1097/00007890-198007000-00005" @default.
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