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- W2093065038 abstract "A gene involved in psoriasis susceptibility was localized to the distal region of human chromosome 17q as a result of a genome-wide linkage analysis with polymorphic microsatellites and eight multiply affected psoriasis kindreds. In the family which showed the strongest evidence for linkage, the recombination fraction between a psoriasis susceptibility locus and D17S784 was 0.04 with a maximum two-point lod score of 5.33. There was also evidence for genetic heterogeneity and although none of the linked families showed any association with HLA-Cw6, two unlinked families showed weak levels of association. This study demonstrates that in some families, psoriasis susceptibility is due to variation at a single major genetic locus other than the human lymphocyte antigen locus." @default.
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- W2093065038 date "1994-05-20" @default.
- W2093065038 modified "2023-10-10" @default.
- W2093065038 title "Gene for Familial Psoriasis Susceptibility Mapped to the Distal End of Human Chromosome 17q" @default.
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- W2093065038 doi "https://doi.org/10.1126/science.8178173" @default.
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