FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093070329> ?p ?o ?g. }

• W2093070329 endingPage "2122" @default.
• W2093070329 startingPage "2113" @default.
• W2093070329 abstract "The pathology of traumatic brain injury (TBI) is characterized by the decreased capacity of neurons to metabolize energy and sustain synaptic function, likely resulting in cognitive and emotional disorders. Based on the broad nature of the pathology, we have assessed the potential of the omega-3 fatty acid docosahexaenoic acid (DHA) to counteract the effects of concussive injury on important aspects of neuronal function and cognition. Fluid percussion injury (FPI) or sham injury was performed, and rats were then maintained on a diet high in DHA (1.2% DHA) for 12 days. We found that DHA supplementation, which elevates brain DHA content, normalized levels of brain-derived neurotrophic factor (BDNF), synapsin I (Syn-1), cAMP-responsive element-binding protein (CREB), and calcium/calmodulin-dependent kinase II (CaMKII), and improved learning ability in FPI rats. It is known that BDNF facilitates synaptic transmission and learning ability by modulating Syn-I, CREB, and CaMKII signaling. The DHA diet also counteracted the FPI-reduced manganese superoxide dismutase (SOD) and Sir2 (a NAD+-dependent deacetylase). Given the involvement of SOD and Sir2 in promoting metabolic homeostasis, DHA may help the injured brain by providing resistance to oxidative stress. Furthermore, DHA normalized levels of calcium-independent phospholipase A2 (iPLA2) and syntaxin-3, which may help preserve membrane homeostasis and function after FPI. The overall results emphasize the potential of dietary DHA to counteract broad and fundamental aspects of TBI pathology that may translate into preserved cognitive capacity." @default.
• W2093070329 created "2016-06-24" @default.
• W2093070329 creator A5038362399 @default.
• W2093070329 creator A5060552570 @default.
• W2093070329 creator A5074815307 @default.
• W2093070329 date "2011-10-01" @default.
• W2093070329 modified "2023-10-16" @default.
• W2093070329 title "The Salutary Effects of DHA Dietary Supplementation on Cognition, Neuroplasticity, and Membrane Homeostasis after Brain Trauma" @default.
• W2093070329 cites W1494460016 @default.
• W2093070329 cites W1505414983 @default.
• W2093070329 cites W1558727857 @default.
• W2093070329 cites W1968177047 @default.
• W2093070329 cites W1973418455 @default.
• W2093070329 cites W1977554176 @default.
• W2093070329 cites W1985023627 @default.
• W2093070329 cites W1986866846 @default.
• W2093070329 cites W1987018561 @default.
• W2093070329 cites W1988607674 @default.
• W2093070329 cites W1990966758 @default.
• W2093070329 cites W1991084221 @default.
• W2093070329 cites W1991585392 @default.
• W2093070329 cites W1991660337 @default.
• W2093070329 cites W1992890638 @default.
• W2093070329 cites W1994215544 @default.
• W2093070329 cites W2003421215 @default.
• W2093070329 cites W2017169966 @default.
• W2093070329 cites W2019124038 @default.
• W2093070329 cites W2021218882 @default.
• W2093070329 cites W2023390598 @default.
• W2093070329 cites W2026258042 @default.
• W2093070329 cites W2031375851 @default.
• W2093070329 cites W2040481490 @default.
• W2093070329 cites W2045777403 @default.
• W2093070329 cites W2054473035 @default.
• W2093070329 cites W2059962058 @default.
• W2093070329 cites W2071523084 @default.
• W2093070329 cites W2091598446 @default.
• W2093070329 cites W2098775852 @default.
• W2093070329 cites W2102501457 @default.
• W2093070329 cites W2103279359 @default.
• W2093070329 cites W2107445350 @default.
• W2093070329 cites W2122007084 @default.
• W2093070329 cites W2124898423 @default.
• W2093070329 cites W2128378957 @default.
• W2093070329 cites W2130009335 @default.
• W2093070329 cites W2131865492 @default.
• W2093070329 cites W2142790764 @default.
• W2093070329 cites W2160899793 @default.
• W2093070329 cites W2171569424 @default.
• W2093070329 cites W287877826 @default.
• W2093070329 cites W4236776871 @default.
• W2093070329 cites W4293156776 @default.
• W2093070329 doi "https://doi.org/10.1089/neu.2011.1872" @default.
• W2093070329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3191367" @default.
• W2093070329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21851229" @default.
• W2093070329 hasPublicationYear "2011" @default.
• W2093070329 type Work @default.
• W2093070329 sameAs 2093070329 @default.
• W2093070329 citedByCount "140" @default.
• W2093070329 countsByYear W20930703292012 @default.
• W2093070329 countsByYear W20930703292013 @default.
• W2093070329 countsByYear W20930703292014 @default.
• W2093070329 countsByYear W20930703292015 @default.
• W2093070329 countsByYear W20930703292016 @default.
• W2093070329 countsByYear W20930703292017 @default.
• W2093070329 countsByYear W20930703292018 @default.
• W2093070329 countsByYear W20930703292019 @default.
• W2093070329 countsByYear W20930703292020 @default.
• W2093070329 countsByYear W20930703292021 @default.
• W2093070329 countsByYear W20930703292022 @default.
• W2093070329 countsByYear W20930703292023 @default.
• W2093070329 crossrefType "journal-article" @default.
• W2093070329 hasAuthorship W2093070329A5038362399 @default.
• W2093070329 hasAuthorship W2093070329A5060552570 @default.
• W2093070329 hasAuthorship W2093070329A5074815307 @default.
• W2093070329 hasBestOaLocation W20930703292 @default.
• W2093070329 hasConcept C104317684 @default.
• W2093070329 hasConcept C118552586 @default.
• W2093070329 hasConcept C126322002 @default.
• W2093070329 hasConcept C130316041 @default.
• W2093070329 hasConcept C134018914 @default.
• W2093070329 hasConcept C148785051 @default.
• W2093070329 hasConcept C160539049 @default.
• W2093070329 hasConcept C1629964 @default.
• W2093070329 hasConcept C169760540 @default.
• W2093070329 hasConcept C170493617 @default.
• W2093070329 hasConcept C19038510 @default.
• W2093070329 hasConcept C2776151105 @default.
• W2093070329 hasConcept C2777171753 @default.
• W2093070329 hasConcept C2778790584 @default.
• W2093070329 hasConcept C2781017439 @default.
• W2093070329 hasConcept C41625074 @default.
• W2093070329 hasConcept C50493954 @default.
• W2093070329 hasConcept C543025807 @default.
• W2093070329 hasConcept C55493867 @default.
• W2093070329 hasConcept C63645605 @default.
• W2093070329 hasConcept C71924100 @default.
• W2093070329 hasConcept C86339819 @default.

• next