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• W2093076603 abstract "Here we describe the detection of T-cell epitope region on the house dust mite allergen Mag 3, which has been shown to trigger T-cell proliferation in mite-allergic asthmatic patients. We first examined murine T-cell epitope using T-cell fraction prepared from recombinant Mag 3 (r-Mag 3)-primed H-2k mice. Initial proliferation assay with truncated r-Mag 3 indicated that N-terminal 113 amino acid region was required for triggering T-cell activation. Subsequent epitope scanning with synthetic overlapping peptides revealed that T-cell reactive region was assigned within amino acid range 56-75. We also explored human T-cell determinant using specific T-cells from mite-allergic patients. Intriguingly, we found that amino acid range 56-85, a portion partially overlapping with that identified in r-Mag 3-primed mice, was exclusively recognized by T-cells from different patients. Further investigation of unique T-cell epitope region found in this study would provide insight into the development of animal therapeutic model and/or peptide vaccine for asthma." @default.
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• W2093076603 date "2000-04-03" @default.
• W2093076603 modified "2023-09-27" @default.
• W2093076603 title "T-cell epitope analysis of Mag 3, an important allergen from the house dust mite, Dermatophagoides farinae" @default.
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• W2093076603 doi "https://doi.org/10.1016/s0165-2478(00)00163-2" @default.
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