FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093080369> ?p ?o ?g. }

• W2093080369 abstract "Calpains belong to a family of calcium-dependent cysteine proteases which are implicated in a myriad of pathologies such as cancer and neurodegeneration. Despite extensive experimental studies on these proteases, our knowledge of the calpain degradome is still limited. Using a dataset of 341 unique, experimentally verified calpain cleavage sites, we conducted extensive sequence analyses and discovered novel residue propensities in the region flanking the cleavage site which could be modeled for prediction using machine learning algorithms. We have developed a series of computational models incorporating support vector machines and Bayes Feature Extraction for the prediction of calpain cleavage sites. The best models achieved AROC and accuracy scores ranging from 0.79 to 0.93 and 71% to 86% respectively when tested on independent test sets. We predicted calpain cleavage sites on proteins from the receptor tyrosine kinase family and discovered potential sites of cleavage at critical regulatory domains. The results suggest a novel role of calpains as a direct regulator of receptor tyrosine kinase activity in cell survival and cell death pathways." @default.
• W2093080369 created "2016-06-24" @default.
• W2093080369 creator A5016790196 @default.
• W2093080369 creator A5062603804 @default.
• W2093080369 date "2012-08-01" @default.
• W2093080369 modified "2023-09-24" @default.
• W2093080369 title "SVM-based prediction of the calpain degradome using Bayes Feature Extraction" @default.
• W2093080369 cites W1969100836 @default.
• W2093080369 cites W1985339713 @default.
• W2093080369 cites W1991719291 @default.
• W2093080369 cites W2016439537 @default.
• W2093080369 cites W2020261641 @default.
• W2093080369 cites W2030060549 @default.
• W2093080369 cites W2034271898 @default.
• W2093080369 cites W2038916773 @default.
• W2093080369 cites W2048356293 @default.
• W2093080369 cites W2049910739 @default.
• W2093080369 cites W2058670812 @default.
• W2093080369 cites W2059248017 @default.
• W2093080369 cites W2061222946 @default.
• W2093080369 cites W2069508712 @default.
• W2093080369 cites W2073908337 @default.
• W2093080369 cites W2074647581 @default.
• W2093080369 cites W2076015897 @default.
• W2093080369 cites W2087898932 @default.
• W2093080369 cites W2095999492 @default.
• W2093080369 cites W2100080081 @default.
• W2093080369 cites W2122460814 @default.
• W2093080369 cites W2126106836 @default.
• W2093080369 cites W2129435178 @default.
• W2093080369 cites W2133893126 @default.
• W2093080369 cites W2139212933 @default.
• W2093080369 cites W2142847551 @default.
• W2093080369 cites W2150506987 @default.
• W2093080369 cites W2153635508 @default.
• W2093080369 cites W2158266834 @default.
• W2093080369 cites W2160965492 @default.
• W2093080369 doi "https://doi.org/10.1109/embc.2012.6347248" @default.
• W2093080369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23367183" @default.
• W2093080369 hasPublicationYear "2012" @default.
• W2093080369 type Work @default.
• W2093080369 sameAs 2093080369 @default.
• W2093080369 citedByCount "3" @default.
• W2093080369 countsByYear W20930803692017 @default.
• W2093080369 countsByYear W20930803692018 @default.
• W2093080369 countsByYear W20930803692019 @default.
• W2093080369 crossrefType "proceedings-article" @default.
• W2093080369 hasAuthorship W2093080369A5016790196 @default.
• W2093080369 hasAuthorship W2093080369A5062603804 @default.
• W2093080369 hasConcept C107673813 @default.
• W2093080369 hasConcept C12267149 @default.
• W2093080369 hasConcept C151730666 @default.
• W2093080369 hasConcept C153180895 @default.
• W2093080369 hasConcept C154945302 @default.
• W2093080369 hasConcept C175156509 @default.
• W2093080369 hasConcept C181199279 @default.
• W2093080369 hasConcept C182220744 @default.
• W2093080369 hasConcept C207201462 @default.
• W2093080369 hasConcept C41008148 @default.
• W2093080369 hasConcept C43369102 @default.
• W2093080369 hasConcept C52001869 @default.
• W2093080369 hasConcept C52622490 @default.
• W2093080369 hasConcept C55493867 @default.
• W2093080369 hasConcept C56928146 @default.
• W2093080369 hasConcept C70721500 @default.
• W2093080369 hasConcept C86803240 @default.
• W2093080369 hasConcept C95444343 @default.
• W2093080369 hasConceptScore W2093080369C107673813 @default.
• W2093080369 hasConceptScore W2093080369C12267149 @default.
• W2093080369 hasConceptScore W2093080369C151730666 @default.
• W2093080369 hasConceptScore W2093080369C153180895 @default.
• W2093080369 hasConceptScore W2093080369C154945302 @default.
• W2093080369 hasConceptScore W2093080369C175156509 @default.
• W2093080369 hasConceptScore W2093080369C181199279 @default.
• W2093080369 hasConceptScore W2093080369C182220744 @default.
• W2093080369 hasConceptScore W2093080369C207201462 @default.
• W2093080369 hasConceptScore W2093080369C41008148 @default.
• W2093080369 hasConceptScore W2093080369C43369102 @default.
• W2093080369 hasConceptScore W2093080369C52001869 @default.
• W2093080369 hasConceptScore W2093080369C52622490 @default.
• W2093080369 hasConceptScore W2093080369C55493867 @default.
• W2093080369 hasConceptScore W2093080369C56928146 @default.
• W2093080369 hasConceptScore W2093080369C70721500 @default.
• W2093080369 hasConceptScore W2093080369C86803240 @default.
• W2093080369 hasConceptScore W2093080369C95444343 @default.
• W2093080369 hasLocation W20930803691 @default.
• W2093080369 hasLocation W20930803692 @default.
• W2093080369 hasOpenAccess W2093080369 @default.
• W2093080369 hasPrimaryLocation W20930803691 @default.
• W2093080369 hasRelatedWork W2093080369 @default.
• W2093080369 hasRelatedWork W2124109643 @default.
• W2093080369 hasRelatedWork W2126100045 @default.
• W2093080369 hasRelatedWork W2145231349 @default.
• W2093080369 hasRelatedWork W2336974148 @default.
• W2093080369 hasRelatedWork W2381773606 @default.
• W2093080369 hasRelatedWork W2539163683 @default.
• W2093080369 hasRelatedWork W4205958290 @default.
• W2093080369 hasRelatedWork W2187500075 @default.
• W2093080369 hasRelatedWork W2345184372 @default.
• W2093080369 isParatext "false" @default.

• next