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- W2093088906 abstract "In this work, a new signal amplification strategy based on hollow PtCo nanochains (HPtCoNCs) functionalized by bi-enzyme-horseradish peroxidase mimicking DNAzyme (HRP-DNAzyme) and glucose oxidase (GOD), as well as ferrocene-labeled secondary thrombin aptamer (Fc-TBA 2), is developed to construct a highly sensitive electrochemical aptasensor. The HRP-DNAzyme contains a special G-quadruplex structure with an intercalated hemin. With the surface area enlarged by HPtCoNCs, the amount of immobilized Fc-TBA 2, hemin and GOD can be enhanced. Under the enzyme catalysis of GOD, d-glucose is rapidly oxidized into gluconic acid accompanying with the generation of H2O2, which is further electrocatalyzed by Pt nanoparticles and HPR-DNAzyme to improve the electrochemical signal of Fc. With several amplification factors mentioned above, a wide linear ranged from 0.001 to 30 nM is acquired with a relatively low detection limit of 0.39 pM for thrombin. The present work demonstrates that using HPtCoNCs as labels is a promising way to amplify the analysis signal and improve the sensitivity of aptasensors." @default.
- W2093088906 created "2016-06-24" @default.
- W2093088906 creator A5035536309 @default.
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- W2093088906 date "2011-07-01" @default.
- W2093088906 modified "2023-10-18" @default.
- W2093088906 title "Bi-enzyme functionlized hollow PtCo nanochains as labels for an electrochemical aptasensor" @default.
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- W2093088906 doi "https://doi.org/10.1016/j.bios.2011.04.032" @default.
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