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- W2093089622 endingPage "975" @default.
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- W2093089622 abstract "Posttranslational modifications of proteins such as phosphorylation have been recognized as pivotal modulators of biological activity in healthy and diseased tissues. Sulfation is a key posttranslational modification the role of which in physiology and pathology is only now becoming appreciated. Whereas phosphorylation is central to intracellular signal transduction, sulfation modulates cell-cell and cell-matrix communication. Sulfation involves a class of enzymes known as sulfotransferases, which transfer sulfate from the ATP-like sulfate donor 3′phosphoadenosine-5′phosphosulate to glycoproteins, glycolipids or metabolites. This review focuses on Golgi-localized sulfotransferases, their molecular biology and biochemistry, and strategies towards discovery of sulfotransferase inhibitors that could have potential as therapeutics in inflammation, cancer and infectious diseases." @default.
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- W2093089622 date "2004-11-01" @default.
- W2093089622 modified "2023-09-27" @default.
- W2093089622 title "Strategies for drug discovery by targeting sulfation pathways" @default.
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- W2093089622 doi "https://doi.org/10.1016/s1359-6446(04)03261-1" @default.
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