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- W2093093344 abstract "Abstract. The elimination process of a substance from the blood stream has been analysed in physical and biochemical terms taking into consideration both the enzyme‐substrate reaction, the possibility of pinocytosis or diffusion and the uneven distribution of the receptor sites in the body. The elimination process was expressed in mathematical terms and simulated in a computer. The elimination curve was studied by changes of different parameters in the equations. It was found that at high substrate concentrations, when the enzyme capacities were saturated, there was a linear elimination rate. The slope of that part of the curve was depending on the enzyme activities. At low concentration the elimination was exponential. The slope of this part of the curve was influenced by changes of the blood flow to the receptor sites. The pinocytotic model was more effective than the enzymatic models under similar conditions, a fact which may be of importance in a biological evolution with competition between different systems." @default.
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- W2093093344 date "1973-01-12" @default.
- W2093093344 modified "2023-10-16" @default.
- W2093093344 title "THE SIMULATION OF THE ELIMINATION PROCESS FOR A SUBSTANCE INJECTED INTO THE BLOOD STREAM" @default.
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- W2093093344 doi "https://doi.org/10.1111/j.0954-6820.1973.tb19427.x" @default.
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