Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093103404> ?p ?o ?g. }
- W2093103404 endingPage "1021" @default.
- W2093103404 startingPage "1013" @default.
- W2093103404 abstract "Although transplantation of skeletal myoblast (SkM) in models of chronic myocardial infarction (MI) induces an improvement in cardiac function, the limited engraftment remains a major limitation. We analyse in a pre-clinical model whether the sequential transplantation of autologous SkM by percutaneous delivery was associated with increased cell engraftment and functional benefit. Chronically infarcted Goettingen minipigs (n = 20) were divided in four groups that received either media control or one, two, or three doses of SkM (mean of 329.6 × 106 cells per dose) at intervals of 6 weeks and were followed for a total of 7 months. At the time of sacrifice, cardiac function was significantly better in animals treated with SkM in comparison with the control group. A significantly greater increase in the ΔLVEF was detected in animals that received three doses vs. a single dose of SkM. A correlation between the total number of transplanted cells and the improvement in LVEF and ΔLVEF was found (P < 0.05). Skeletal myoblast transplant was associated with an increase in tissue vasculogenesis and decreased fibrosis (collagen vascular fraction) and these effects were greater in animals receiving three doses of cells. Repeated injection of SkM in a model of chronic MI is feasible and safe and induces a significant improvement in cardiac function." @default.
- W2093103404 created "2016-06-24" @default.
- W2093103404 creator A5003087589 @default.
- W2093103404 creator A5010162631 @default.
- W2093103404 creator A5015094950 @default.
- W2093103404 creator A5016030888 @default.
- W2093103404 creator A5023348035 @default.
- W2093103404 creator A5029998120 @default.
- W2093103404 creator A5034476139 @default.
- W2093103404 creator A5034971794 @default.
- W2093103404 creator A5035460617 @default.
- W2093103404 creator A5056876340 @default.
- W2093103404 creator A5059491868 @default.
- W2093103404 creator A5087575355 @default.
- W2093103404 date "2009-08-22" @default.
- W2093103404 modified "2023-10-18" @default.
- W2093103404 title "Repeated implantation of skeletal myoblast in a swine model of chronic myocardial infarction" @default.
- W2093103404 cites W189185435 @default.
- W2093103404 cites W1969834344 @default.
- W2093103404 cites W1995174454 @default.
- W2093103404 cites W2000006332 @default.
- W2093103404 cites W2005016150 @default.
- W2093103404 cites W2009545124 @default.
- W2093103404 cites W2018624715 @default.
- W2093103404 cites W2026315775 @default.
- W2093103404 cites W2037475505 @default.
- W2093103404 cites W2039412917 @default.
- W2093103404 cites W2045382887 @default.
- W2093103404 cites W2054540361 @default.
- W2093103404 cites W2059956719 @default.
- W2093103404 cites W2064917931 @default.
- W2093103404 cites W2067335193 @default.
- W2093103404 cites W2072740783 @default.
- W2093103404 cites W2076837609 @default.
- W2093103404 cites W2087604634 @default.
- W2093103404 cites W2089431975 @default.
- W2093103404 cites W2090785038 @default.
- W2093103404 cites W2098849525 @default.
- W2093103404 cites W2114222046 @default.
- W2093103404 cites W2124396531 @default.
- W2093103404 cites W2125931106 @default.
- W2093103404 cites W2126916359 @default.
- W2093103404 cites W2129530104 @default.
- W2093103404 cites W2129570558 @default.
- W2093103404 cites W2129991791 @default.
- W2093103404 cites W2134704099 @default.
- W2093103404 cites W2142256658 @default.
- W2093103404 cites W2144116641 @default.
- W2093103404 cites W2144547348 @default.
- W2093103404 cites W2145000376 @default.
- W2093103404 cites W2151722542 @default.
- W2093103404 cites W2155419259 @default.
- W2093103404 cites W2158682140 @default.
- W2093103404 cites W2160293700 @default.
- W2093103404 cites W2167595513 @default.
- W2093103404 cites W2169859308 @default.
- W2093103404 cites W2170871745 @default.
- W2093103404 cites W2329775266 @default.
- W2093103404 cites W2100531804 @default.
- W2093103404 doi "https://doi.org/10.1093/eurheartj/ehp342" @default.
- W2093103404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19700775" @default.
- W2093103404 hasPublicationYear "2009" @default.
- W2093103404 type Work @default.
- W2093103404 sameAs 2093103404 @default.
- W2093103404 citedByCount "54" @default.
- W2093103404 countsByYear W20931034042012 @default.
- W2093103404 countsByYear W20931034042013 @default.
- W2093103404 countsByYear W20931034042014 @default.
- W2093103404 countsByYear W20931034042015 @default.
- W2093103404 countsByYear W20931034042016 @default.
- W2093103404 countsByYear W20931034042017 @default.
- W2093103404 countsByYear W20931034042018 @default.
- W2093103404 countsByYear W20931034042019 @default.
- W2093103404 countsByYear W20931034042020 @default.
- W2093103404 countsByYear W20931034042021 @default.
- W2093103404 countsByYear W20931034042022 @default.
- W2093103404 countsByYear W20931034042023 @default.
- W2093103404 crossrefType "journal-article" @default.
- W2093103404 hasAuthorship W2093103404A5003087589 @default.
- W2093103404 hasAuthorship W2093103404A5010162631 @default.
- W2093103404 hasAuthorship W2093103404A5015094950 @default.
- W2093103404 hasAuthorship W2093103404A5016030888 @default.
- W2093103404 hasAuthorship W2093103404A5023348035 @default.
- W2093103404 hasAuthorship W2093103404A5029998120 @default.
- W2093103404 hasAuthorship W2093103404A5034476139 @default.
- W2093103404 hasAuthorship W2093103404A5034971794 @default.
- W2093103404 hasAuthorship W2093103404A5035460617 @default.
- W2093103404 hasAuthorship W2093103404A5056876340 @default.
- W2093103404 hasAuthorship W2093103404A5059491868 @default.
- W2093103404 hasAuthorship W2093103404A5087575355 @default.
- W2093103404 hasBestOaLocation W20931034041 @default.
- W2093103404 hasConcept C111566952 @default.
- W2093103404 hasConcept C126322002 @default.
- W2093103404 hasConcept C164705383 @default.
- W2093103404 hasConcept C207200792 @default.
- W2093103404 hasConcept C2777798775 @default.
- W2093103404 hasConcept C2778198053 @default.
- W2093103404 hasConcept C2780559512 @default.