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- W209311946 abstract "Rabies is a viral infection with a high case fatality rate. Typical symptoms of rabies include hydrophobia, pharynx muscle spasms, and progressive paralysis. Rabies-induced persistent mental disturbances are rare. Here we report a 22-year-old male who was infected with rabies after being attacked by a dog. He did not receive rabies vaccine immediately after the incident and was only provided with non-standard treatment at a local clinic. A week later he became disorientated, paranoid, and aggressive. One month after the attack, rabies antibody was found in his cerebrospinal fluid and a Magnetic Resonance Imaging (MRI) examination of his head revealed abnormal signals in the putamina, caudate nucleus, and insula. His mental symptoms persisted for six years and his daily functioning was severely impaired, but his vital signs were stable without signs of brain stem damage. Six years after the incident, a repeat MRI showed brain atrophy. 狂犬病是一种致死率很高的病毒性传染疾病。狂犬病的典型症状包括恐水症、咽肌痉挛和进行性瘫痪。狂犬病所致的持续性精神障碍较为罕见。这里报道一名22岁的男性狂犬病患者。该患者自被病狗咬伤后，没有立即接种狂犬病疫苗，而只是在当地诊所不规范治疗。一周后，患者出现定向障碍、偏执，并表现出攻击性。咬伤后一个月，患者脑脊液中检测到狂犬病病毒抗体，头颅磁共振成像（MRI）显示豆状核、尾状核以及岛叶异常信号影。患者的精神症状持续了6年，生活不能自理，但生命体征平稳，无脑干受损表现。发病6年后再次检查头颅MRI，检查结果为脑萎缩。.本文全文中文版从2015年4月8日起在http://dx.doi.org/10.11919/j.issn.1002-0829.214174可供免费阅览下载." @default.
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- W209311946 date "2015-02-25" @default.
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- W209311946 title "Case report of rabies-induced persistent mental symptoms." @default.
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- W209311946 doi "https://doi.org/10.11919/j.issn.1002-0829.214174" @default.
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