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• W2093122630 endingPage "7034" @default.
• W2093122630 startingPage "7034" @default.
• W2093122630 abstract "Purpose.: Stimulation to the cornea via noxious chemical and mechanical means evokes tearing, blinking, and pain. In contrast, mild cooling of the ocular surface has been reported to increase lacrimation via activation of corneal cool primary afferent neurons. The purpose of our study was to determine whether menthol induces corneal cool cell activity and lacrimation via the transient receptor potential melastatin-8 (TRPM8) channel without evoking nociceptive responses. Methods.: Tear measurements were made using a cotton thread in TRPM8 wild type and knockout mice after application of menthol (0.05–50 mM) to the cornea. In additional studies, nocifensive responses (eye swiping and lid closure) were quantified following cornea menthol application. Trigeminal ganglion electrophysiologic single unit recordings were performed in rats to determine the effect of low and high concentrations of menthol on corneal cool cells. Results.: At low concentrations, menthol increased tear production in TRPM8 wild type and heterozygous animals, but had no effect in TRPM8 knockout mice, while nocifensive responses remained unaffected. At the highest concentration, menthol (50 mM) increased tearing and nocifensive responses in TRPM8 wild type and knockout animals. A low concentration of menthol (0.1 mM) increased cool cell activity, yet a high concentration of menthol (50 mM) had no effect. Conclusions.: These studies indicated that low concentrations of menthol can increase lacrimation via TRPM8 channels without evoking nocifensive behaviors. At high concentrations, menthol can induce lacrimation and nocifensive behaviors in a TRPM8 independent mechanism. The increase in lacrimation is likely due to an increase in cool cell activity." @default.
• W2093122630 created "2016-06-24" @default.
• W2093122630 creator A5019282393 @default.
• W2093122630 creator A5025856564 @default.
• W2093122630 creator A5052874314 @default.
• W2093122630 creator A5065734078 @default.
• W2093122630 date "2012-10-09" @default.
• W2093122630 modified "2023-09-24" @default.
• W2093122630 title "Menthol Activation of Corneal Cool Cells Induces TRPM8-Mediated Lacrimation but Not Nociceptive Responses in Rodents" @default.
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• W2093122630 doi "https://doi.org/10.1167/iovs.12-10025" @default.
• W2093122630 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3471555" @default.
• W2093122630 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22952122" @default.
• W2093122630 hasPublicationYear "2012" @default.
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