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- W2093123034 endingPage "2273" @default.
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- W2093123034 abstract "Many calcium channels can distinguish between ions of the same charge but different size. For example, when cations are in direct competition with each other, the ryanodine receptor (RyR) calcium channel preferentially conducts smaller cations such as Li(+) and Na(+) over larger ones such as K(+) and Cs(+). Here, we analyze the physical basis for this preference using a previously established model of RyR permeation and selectivity. Like other calcium channels, RyR has four aspartate residues in its GGGIGDE selectivity filter. These aspartates have their terminal carboxyl group in the pore lumen, which take up much of the available space for permeating ions. We find that small ions are preferred by RyR because they can fit into this crowded environment more easily." @default.
- W2093123034 created "2016-06-24" @default.
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- W2093123034 date "2014-11-01" @default.
- W2093123034 modified "2023-10-14" @default.
- W2093123034 title "Selecting Ions by Size in a Calcium Channel: The Ryanodine Receptor Case Study" @default.
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- W2093123034 doi "https://doi.org/10.1016/j.bpj.2014.09.031" @default.
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