Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093130211> ?p ?o ?g. }
- W2093130211 endingPage "86" @default.
- W2093130211 startingPage "77" @default.
- W2093130211 abstract "Double-stranded RNA (dsRNA) plays a role in the regulation of cell growth and apoptosis as well as in the cellular antiviral responses. However, it remains unknown if dsRNA-activated signaling systems are functional in the thyroid. Here we report the presence of the dsRNA-dependent protein kinase (PKR) in FRTL-5 rat thyroid cells. In poly(I)-poly(C) (pIC)-stimulated cells, activation of nuclear factor-kappa B (NF kappa B) binding was clearly induced. Incubation of FRTL-5 cells with pIC resulted in a marked increase in interferon regulatory factor-1 (IRF-1) mRNA and phosphorylated signal transducer and activator of transcription-1 (STAT1) levels. Addition of pIC to cells led to type I interferon (IFN) gene expression, especially IFN beta, which can induce STAT1 phosphorylation, suggesting that dsRNA indirectly induced STAT1 phosphorylation through expression of type I IFN. Thus, our results suggest that the dsRNA-activated signaling pathway may be involved in the regulation of IFN-inducible genes in the thyroid." @default.
- W2093130211 created "2016-06-24" @default.
- W2093130211 creator A5004116787 @default.
- W2093130211 creator A5019825512 @default.
- W2093130211 creator A5029070325 @default.
- W2093130211 creator A5038102022 @default.
- W2093130211 creator A5046338027 @default.
- W2093130211 creator A5063823736 @default.
- W2093130211 date "2001-11-01" @default.
- W2093130211 modified "2023-09-24" @default.
- W2093130211 title "Double-stranded RNA-induced interferon regulatory factor-1 gene expression in FRTL-5 rat thyroid cells" @default.
- W2093130211 cites W1514099677 @default.
- W2093130211 cites W1538444363 @default.
- W2093130211 cites W1545795848 @default.
- W2093130211 cites W1824777900 @default.
- W2093130211 cites W1964733610 @default.
- W2093130211 cites W1968987342 @default.
- W2093130211 cites W1977795184 @default.
- W2093130211 cites W1979451677 @default.
- W2093130211 cites W1980935930 @default.
- W2093130211 cites W1982123534 @default.
- W2093130211 cites W1982794558 @default.
- W2093130211 cites W1985703111 @default.
- W2093130211 cites W1989136432 @default.
- W2093130211 cites W1997261857 @default.
- W2093130211 cites W1998115646 @default.
- W2093130211 cites W2005968120 @default.
- W2093130211 cites W2008356119 @default.
- W2093130211 cites W2021951044 @default.
- W2093130211 cites W2029275361 @default.
- W2093130211 cites W2037772620 @default.
- W2093130211 cites W2045081659 @default.
- W2093130211 cites W2069659862 @default.
- W2093130211 cites W2083445717 @default.
- W2093130211 cites W2084472569 @default.
- W2093130211 cites W2085767188 @default.
- W2093130211 cites W2088223086 @default.
- W2093130211 cites W2100837269 @default.
- W2093130211 cites W2130104095 @default.
- W2093130211 cites W2139902700 @default.
- W2093130211 cites W2149758484 @default.
- W2093130211 cites W2154445812 @default.
- W2093130211 cites W2161832141 @default.
- W2093130211 cites W2169726425 @default.
- W2093130211 cites W4293247451 @default.
- W2093130211 cites W4294216491 @default.
- W2093130211 cites W4322574958 @default.
- W2093130211 doi "https://doi.org/10.1016/s0303-7207(01)00641-4" @default.
- W2093130211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11694343" @default.
- W2093130211 hasPublicationYear "2001" @default.
- W2093130211 type Work @default.
- W2093130211 sameAs 2093130211 @default.
- W2093130211 citedByCount "7" @default.
- W2093130211 countsByYear W20931302112012 @default.
- W2093130211 crossrefType "journal-article" @default.
- W2093130211 hasAuthorship W2093130211A5004116787 @default.
- W2093130211 hasAuthorship W2093130211A5019825512 @default.
- W2093130211 hasAuthorship W2093130211A5029070325 @default.
- W2093130211 hasAuthorship W2093130211A5038102022 @default.
- W2093130211 hasAuthorship W2093130211A5046338027 @default.
- W2093130211 hasAuthorship W2093130211A5063823736 @default.
- W2093130211 hasConcept C104317684 @default.
- W2093130211 hasConcept C11960822 @default.
- W2093130211 hasConcept C150194340 @default.
- W2093130211 hasConcept C153911025 @default.
- W2093130211 hasConcept C159047783 @default.
- W2093130211 hasConcept C161238802 @default.
- W2093130211 hasConcept C166703698 @default.
- W2093130211 hasConcept C171958077 @default.
- W2093130211 hasConcept C2191507 @default.
- W2093130211 hasConcept C2776178377 @default.
- W2093130211 hasConcept C2777003663 @default.
- W2093130211 hasConcept C2778923194 @default.
- W2093130211 hasConcept C55493867 @default.
- W2093130211 hasConcept C62478195 @default.
- W2093130211 hasConcept C67705224 @default.
- W2093130211 hasConcept C82495950 @default.
- W2093130211 hasConcept C86339819 @default.
- W2093130211 hasConcept C86803240 @default.
- W2093130211 hasConcept C88045685 @default.
- W2093130211 hasConcept C9173399 @default.
- W2093130211 hasConcept C95444343 @default.
- W2093130211 hasConcept C97029542 @default.
- W2093130211 hasConceptScore W2093130211C104317684 @default.
- W2093130211 hasConceptScore W2093130211C11960822 @default.
- W2093130211 hasConceptScore W2093130211C150194340 @default.
- W2093130211 hasConceptScore W2093130211C153911025 @default.
- W2093130211 hasConceptScore W2093130211C159047783 @default.
- W2093130211 hasConceptScore W2093130211C161238802 @default.
- W2093130211 hasConceptScore W2093130211C166703698 @default.
- W2093130211 hasConceptScore W2093130211C171958077 @default.
- W2093130211 hasConceptScore W2093130211C2191507 @default.
- W2093130211 hasConceptScore W2093130211C2776178377 @default.
- W2093130211 hasConceptScore W2093130211C2777003663 @default.
- W2093130211 hasConceptScore W2093130211C2778923194 @default.
- W2093130211 hasConceptScore W2093130211C55493867 @default.
- W2093130211 hasConceptScore W2093130211C62478195 @default.
- W2093130211 hasConceptScore W2093130211C67705224 @default.