Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093132221> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2093132221 endingPage "281" @default.
- W2093132221 startingPage "277" @default.
- W2093132221 abstract "Autologous mixed lymphocyte cultures (AMC) with T-enriched subset of human blood lymphocytes as responders and B-cells or plastic adherent cells as stimulators and allogeneic mixed lymphocyte cultures (MLC) were assayed for blastogenesis and generation of cytotoxic potential. The activated cells lyzed K562 and Daudi, autologous and allogeneic PHA-blasts. The AMC population affected the autologous and allogeneic blasts at a similar strength and there was no indication for selective effects. B-Blasts induced with Staphylococcus aureus were not lyzed. The MLC populations had a stimulation-specific cytotoxic component. This was revealed by the stronger effect against the stimulator PHA-blasts and by the lysis of the stimulator B-blasts. Short-time interferon (IFN) treatment prior to the lytic assay enhanced the anti-Daudi and anti-K562 lytic activity of the AMC and MLC populations. With AMC the lytic efficiency against the autologous and allogeneic PHA-blasts were not changed while with MLC they were also elevated. This increase was confined to the non-specific component of the cytotoxicity. The proliferation of lymphocytes was suppressed when interferon was added at the initiation of the mixed cultures. On a per-cell basis the cytotoxic potential of these cultures were stronger. In the MLC the stimulation-specific component increased more substantially than the effect against the non-specific targets. It is possible that the IFN-induced modification of the culture conditions such as suppression of the initial proliferation favored the growth of the specific clone. Re-exposure of these cells to another dose of interferon prior to the lytic assay had no effect on the lytic potential." @default.
- W2093132221 created "2016-06-24" @default.
- W2093132221 creator A5006412648 @default.
- W2093132221 creator A5061350230 @default.
- W2093132221 date "1982-11-01" @default.
- W2093132221 modified "2023-10-16" @default.
- W2093132221 title "IFN-α-induced modulations of the events in human mixed lymphocyte cultures" @default.
- W2093132221 cites W1569135081 @default.
- W2093132221 cites W1974218008 @default.
- W2093132221 cites W2019197302 @default.
- W2093132221 cites W2022633205 @default.
- W2093132221 cites W2024318335 @default.
- W2093132221 cites W2052439829 @default.
- W2093132221 cites W2077622055 @default.
- W2093132221 cites W2118552033 @default.
- W2093132221 cites W2412519231 @default.
- W2093132221 doi "https://doi.org/10.1016/0165-2478(82)90112-2" @default.
- W2093132221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6219067" @default.
- W2093132221 hasPublicationYear "1982" @default.
- W2093132221 type Work @default.
- W2093132221 sameAs 2093132221 @default.
- W2093132221 citedByCount "0" @default.
- W2093132221 crossrefType "journal-article" @default.
- W2093132221 hasAuthorship W2093132221A5006412648 @default.
- W2093132221 hasAuthorship W2093132221A5061350230 @default.
- W2093132221 hasConcept C109316439 @default.
- W2093132221 hasConcept C134018914 @default.
- W2093132221 hasConcept C153911025 @default.
- W2093132221 hasConcept C154317977 @default.
- W2093132221 hasConcept C171122931 @default.
- W2093132221 hasConcept C182615771 @default.
- W2093132221 hasConcept C202751555 @default.
- W2093132221 hasConcept C203014093 @default.
- W2093132221 hasConcept C24998067 @default.
- W2093132221 hasConcept C2522874641 @default.
- W2093132221 hasConcept C2776178377 @default.
- W2093132221 hasConcept C2777761686 @default.
- W2093132221 hasConcept C2778461978 @default.
- W2093132221 hasConcept C2908647359 @default.
- W2093132221 hasConcept C552990157 @default.
- W2093132221 hasConcept C55493867 @default.
- W2093132221 hasConcept C57409179 @default.
- W2093132221 hasConcept C71924100 @default.
- W2093132221 hasConcept C73588182 @default.
- W2093132221 hasConcept C81089528 @default.
- W2093132221 hasConcept C86803240 @default.
- W2093132221 hasConcept C99454951 @default.
- W2093132221 hasConceptScore W2093132221C109316439 @default.
- W2093132221 hasConceptScore W2093132221C134018914 @default.
- W2093132221 hasConceptScore W2093132221C153911025 @default.
- W2093132221 hasConceptScore W2093132221C154317977 @default.
- W2093132221 hasConceptScore W2093132221C171122931 @default.
- W2093132221 hasConceptScore W2093132221C182615771 @default.
- W2093132221 hasConceptScore W2093132221C202751555 @default.
- W2093132221 hasConceptScore W2093132221C203014093 @default.
- W2093132221 hasConceptScore W2093132221C24998067 @default.
- W2093132221 hasConceptScore W2093132221C2522874641 @default.
- W2093132221 hasConceptScore W2093132221C2776178377 @default.
- W2093132221 hasConceptScore W2093132221C2777761686 @default.
- W2093132221 hasConceptScore W2093132221C2778461978 @default.
- W2093132221 hasConceptScore W2093132221C2908647359 @default.
- W2093132221 hasConceptScore W2093132221C552990157 @default.
- W2093132221 hasConceptScore W2093132221C55493867 @default.
- W2093132221 hasConceptScore W2093132221C57409179 @default.
- W2093132221 hasConceptScore W2093132221C71924100 @default.
- W2093132221 hasConceptScore W2093132221C73588182 @default.
- W2093132221 hasConceptScore W2093132221C81089528 @default.
- W2093132221 hasConceptScore W2093132221C86803240 @default.
- W2093132221 hasConceptScore W2093132221C99454951 @default.
- W2093132221 hasIssue "5" @default.
- W2093132221 hasLocation W20931322211 @default.
- W2093132221 hasLocation W20931322212 @default.
- W2093132221 hasOpenAccess W2093132221 @default.
- W2093132221 hasPrimaryLocation W20931322211 @default.
- W2093132221 hasRelatedWork W1486874446 @default.
- W2093132221 hasRelatedWork W1923560168 @default.
- W2093132221 hasRelatedWork W1939478204 @default.
- W2093132221 hasRelatedWork W2038272141 @default.
- W2093132221 hasRelatedWork W2065812440 @default.
- W2093132221 hasRelatedWork W2074989987 @default.
- W2093132221 hasRelatedWork W2094853737 @default.
- W2093132221 hasRelatedWork W2127301942 @default.
- W2093132221 hasRelatedWork W2409134249 @default.
- W2093132221 hasRelatedWork W1981530385 @default.
- W2093132221 hasVolume "5" @default.
- W2093132221 isParatext "false" @default.
- W2093132221 isRetracted "false" @default.
- W2093132221 magId "2093132221" @default.
- W2093132221 workType "article" @default.