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- W2093135503 abstract "The effect of droperidol on miniature endplate potential (mepp) frequency and amplitude, acetylcholine sensitivity, action potential generation, twitch tension, input resistance and alteration of acetylcholine release were studied in frog muscle. Interaction with d-tubocurarine was studied in the cat sciatic gastrocnemius preparation. Between 10 −11 and 10 −7 g/l droperidol did not change mepp frequency or amplitude. Between 7.5 × 10 −6 and 2.5 × 10 −5 g/l mepp amplitude, endplate sensitivity to acetylcholine and twitch tension were depressed. At 5 × 10 −5 g/l the threshold for action potential generation increased while amplitude and rate of rise decreased. Input resistance was unaltered. With indirect interrupted tetanic stimulation of the muscle for 30 min droperidol 10 −6 to 10 −4 g/l reduced the contraction height while acetylcholine release was concomitantly depressed. Droperidol 10 mg/kg in cats did not block muscle contraction, but combination with d-tubocurarine prolonged recovery time." @default.
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- W2093135503 date "1974-09-01" @default.
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- W2093135503 title "Effects of droperidol on neuromuscular transmission and muscle membrane" @default.
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- W2093135503 doi "https://doi.org/10.1016/0014-2999(74)90133-2" @default.
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