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- W2093140752 abstract "Objectives: The study prospectively analyses the different diagnosis methods for tuberculous meningitis available in Infectious Diseases Hospital Iasi, Romania. Material and Method: We prospectively studied the cases of tuberculous meningitis admitted from January 1st till October 2007 in our hospital, regarding epidemiological, clinical data and laboratory methods of diagnosis: cerebrospinal fluid examination and culture, tuberculin skin test, radiological assays and quantification of gamma-interferon in blood and cerebrospinal fluid using Quantiferon TBGold assay (QTF). Results: The patients were divided in 2 groups: one of 17 patients with TB meningitis and one control group of 28 patients with either bacterial (3c), lymphocytic meningitis (17c) or without central nervous system infection (7c). TB meningitis was more frequent in males, with a mean ratio of 2.5. The age of patients varied between 2 and 78 years, with a mean of 30.5 years. Many of the patients were children (35.6%) and 40% were older than 36 years. In 71.1% (32c) of the cases the meningean infection was secondary, disseminated from a primary site, most frequent a pulmonary one (68.7%). We had bacteriological confirmation by culture in 6 cases (13.3%), with a medium of 23.4 days of cultivation time. For the other cases the diagnosis was established by clinical data, cell count and biochemical analysis of CSF, the presence of extrameningean tuberculous infection and positive evolution under antituberculous therapy. TST was performed to all the patients except 3 AIDS patients; it had a sensitivity of 71.4% and a specificity of 62.5%. In whole blood the sensitivity of QTF was 78.57. In CSF the specificity was higher than in blood (96.1 vs 88.4%), having a positive prediction value over 90%. Antituberculous therapy prior to QTF testing had a negative impact, 5 of 6 cases having negative QTF results. Conclusion: QTF (serum or CSF) had a better sensibility and specificity than TST, CSF direct exam or culture and could be used to establish an early diagnosis of tuberculous meningitis." @default.
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- W2093140752 date "2008-12-01" @default.
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- W2093140752 title "Usefulness of Gamma-Interferon Determination in Blood and Cerebrospinal Fluid for the Diagnosis of Tuberculous Meningitis" @default.
- W2093140752 doi "https://doi.org/10.1016/j.ijid.2008.05.855" @default.
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