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- W2093142724 abstract "Recent experience has prompted the US FDA to consider whether ethanol ingestion may modify the release characteristics of prolonged-release formulations, where dose dumping may be an issue for patient safety.The influence of ethanol on the in vitro release of opioid drugs from some prolonged-release formulations utilizing different release technologies was examined. Results indicated that the prolonged-release mechanisms remained intact under the testing conditions, although one product showed initial sensitivity to ethanol in its release characteristics. Nevertheless, in this case, extrapolation of the findings to likely outcome in vivo indicated no risk of dose-dumping.It is proposed that prolonged-release medicinal products should be tested during development to ensure robustness to the effects of ethanol on drug release." @default.
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- W2093142724 date "2007-01-01" @default.
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- W2093142724 title "The Effect of Ethanol on the Release of Opioids from Oral Prolonged-Release Preparations" @default.
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- W2093142724 doi "https://doi.org/10.1080/03639040701377292" @default.
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