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• W2093144498 startingPage "3244" @default.
• W2093144498 abstract "The ryanodine receptor-like Ca2+ channel (RyRLC) is responsible for Ca2+ wave propagation and Ca2+ oscillations in certain nonmuscle cells by a Ca(2+)-induced Ca2+ release (CICR) mechanism. Cyclic ADP-ribose (cADPR), an enzymatic product derived from NAD+, is the only known endogenous metabolite that acts as an agonist on the RyRLC. However, the mode of action of cADPR is not clear. We have identified calmodulin as a functional mediator of cADPR-triggered CICR through the RyRLC in sea urchin eggs. cADPR-induced Ca2+ release consisted of two phases, an initial rapid release phase and a subsequent slower release. The second phase was selectively potentiated by calmodulin which, in turn, was activated by Ca2+ released during the initial phase. Caffeine enhanced the action of calmodulin. Calmodulin did not play a role in inositol 1,4,5-trisphosphate-induced Ca2+ release. These findings offer insights into the multiple pathways that regulate intracellular Ca2+ signaling." @default.
• W2093144498 created "2016-06-24" @default.
• W2093144498 creator A5047629088 @default.
• W2093144498 creator A5073132850 @default.
• W2093144498 date "1995-04-11" @default.
• W2093144498 modified "2023-09-24" @default.
• W2093144498 title "Calmodulin is a selective mediator of Ca(2+)-induced Ca2+ release via the ryanodine receptor-like Ca2+ channel triggered by cyclic ADP-ribose." @default.
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• W2093144498 doi "https://doi.org/10.1073/pnas.92.8.3244" @default.
• W2093144498 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/42142" @default.
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