FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2093146923> ?p ?o ?g. }

• W2093146923 endingPage "31" @default.
• W2093146923 startingPage "20" @default.
• W2093146923 abstract "The antiproliferative effect of simvastatin on tumor cells has been speculated to be by intracellular signal inhibition through 3-hydroxy-3-methylglutaryl acetyl coenzyme A reductase. We examined the killing effect of simvastatin on imatinib-sensitive and resistant chronic myelogenous leukemia (CML) cells (three kinds of CML cell lines representative of each hematopoietic lineage: K562, KCL22, and LAMA84) and T315I and E255K site-directed mutant cells (Ba/F3). The in-vivo effect of simvastatin was determined in K562-xenografted nude mice. Cotreatment with imatinib and simvastatin in imatinib-resistant CML cells showed a synergistic killing effect in K562-R, KCL22-R, LAMA84-R, and E255K mutant cells, but only an additive effect in the T315I mutant cell, although a single treatment of simvastatin strongly inhibited T315I mutant cells. Mechanisms of killing were an induction of apoptosis and cell cycle arrest, through inhibition of tyrosine phosphorylation, and activated STAT5 and STAT3. Simvastatin suppressed the growth of K562-transplanted tumors, and cotreatment with imatinib was more effective in reducing tumor size. Simvastatin also killed primary CD34+ cells from patients with CML more efficiently, compared with CD34− CML cells. Our study shows a synergic effect of imatinib and simvastatin both in imatinib-sensitive and imatinib-resistant cells, but more effective synergism in resistant cells. On the basis of these findings, we suggest that a combination of simvastatin and imatinib may be a potential candidate for the treatment of imatinib-resistant CML." @default.
• W2093146923 created "2016-06-24" @default.
• W2093146923 creator A5027156692 @default.
• W2093146923 creator A5039011456 @default.
• W2093146923 creator A5049032346 @default.
• W2093146923 creator A5051391875 @default.
• W2093146923 creator A5070434251 @default.
• W2093146923 creator A5074951962 @default.
• W2093146923 creator A5082783833 @default.
• W2093146923 creator A5090388397 @default.
• W2093146923 date "2013-01-01" @default.
• W2093146923 modified "2023-09-23" @default.
• W2093146923 title "Synergistic killing effect of imatinib and simvastatin on imatinib-resistant chronic myelogenous leukemia cells" @default.
• W2093146923 cites W120419820 @default.
• W2093146923 cites W1490418776 @default.
• W2093146923 cites W1951308530 @default.
• W2093146923 cites W1964088193 @default.
• W2093146923 cites W1966917258 @default.
• W2093146923 cites W1973720500 @default.
• W2093146923 cites W1974198171 @default.
• W2093146923 cites W1976915409 @default.
• W2093146923 cites W1990042184 @default.
• W2093146923 cites W1995456504 @default.
• W2093146923 cites W1996644539 @default.
• W2093146923 cites W2006778638 @default.
• W2093146923 cites W2011474502 @default.
• W2093146923 cites W2015538356 @default.
• W2093146923 cites W2028959752 @default.
• W2093146923 cites W2032890774 @default.
• W2093146923 cites W2034843329 @default.
• W2093146923 cites W2040396943 @default.
• W2093146923 cites W2041460867 @default.
• W2093146923 cites W2042200885 @default.
• W2093146923 cites W2043707585 @default.
• W2093146923 cites W2049659810 @default.
• W2093146923 cites W2059659076 @default.
• W2093146923 cites W2064153983 @default.
• W2093146923 cites W2071255986 @default.
• W2093146923 cites W2074740152 @default.
• W2093146923 cites W2076624216 @default.
• W2093146923 cites W2082097264 @default.
• W2093146923 cites W2082580993 @default.
• W2093146923 cites W2107015590 @default.
• W2093146923 cites W2113703021 @default.
• W2093146923 cites W2118154631 @default.
• W2093146923 cites W2145376550 @default.
• W2093146923 cites W2152208557 @default.
• W2093146923 cites W2155421604 @default.
• W2093146923 cites W2263837564 @default.
• W2093146923 cites W2314938037 @default.
• W2093146923 cites W2315691043 @default.
• W2093146923 cites W2329648702 @default.
• W2093146923 doi "https://doi.org/10.1097/cad.0b013e32835a0fbd" @default.
• W2093146923 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23075630" @default.
• W2093146923 hasPublicationYear "2013" @default.
• W2093146923 type Work @default.
• W2093146923 sameAs 2093146923 @default.
• W2093146923 citedByCount "23" @default.
• W2093146923 countsByYear W20931469232013 @default.
• W2093146923 countsByYear W20931469232014 @default.
• W2093146923 countsByYear W20931469232016 @default.
• W2093146923 countsByYear W20931469232017 @default.
• W2093146923 countsByYear W20931469232018 @default.
• W2093146923 countsByYear W20931469232019 @default.
• W2093146923 countsByYear W20931469232020 @default.
• W2093146923 countsByYear W20931469232021 @default.
• W2093146923 countsByYear W20931469232023 @default.
• W2093146923 crossrefType "journal-article" @default.
• W2093146923 hasAuthorship W2093146923A5027156692 @default.
• W2093146923 hasAuthorship W2093146923A5039011456 @default.
• W2093146923 hasAuthorship W2093146923A5049032346 @default.
• W2093146923 hasAuthorship W2093146923A5051391875 @default.
• W2093146923 hasAuthorship W2093146923A5070434251 @default.
• W2093146923 hasAuthorship W2093146923A5074951962 @default.
• W2093146923 hasAuthorship W2093146923A5082783833 @default.
• W2093146923 hasAuthorship W2093146923A5090388397 @default.
• W2093146923 hasConcept C171122931 @default.
• W2093146923 hasConcept C203014093 @default.
• W2093146923 hasConcept C2776329913 @default.
• W2093146923 hasConcept C2776960273 @default.
• W2093146923 hasConcept C2777583451 @default.
• W2093146923 hasConcept C2778461978 @default.
• W2093146923 hasConcept C2778729363 @default.
• W2093146923 hasConcept C3019892230 @default.
• W2093146923 hasConcept C502942594 @default.
• W2093146923 hasConcept C71924100 @default.
• W2093146923 hasConcept C98274493 @default.
• W2093146923 hasConceptScore W2093146923C171122931 @default.
• W2093146923 hasConceptScore W2093146923C203014093 @default.
• W2093146923 hasConceptScore W2093146923C2776329913 @default.
• W2093146923 hasConceptScore W2093146923C2776960273 @default.
• W2093146923 hasConceptScore W2093146923C2777583451 @default.
• W2093146923 hasConceptScore W2093146923C2778461978 @default.
• W2093146923 hasConceptScore W2093146923C2778729363 @default.
• W2093146923 hasConceptScore W2093146923C3019892230 @default.
• W2093146923 hasConceptScore W2093146923C502942594 @default.
• W2093146923 hasConceptScore W2093146923C71924100 @default.
• W2093146923 hasConceptScore W2093146923C98274493 @default.

• next