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• W2093148933 endingPage "615" @default.
• W2093148933 startingPage "609" @default.
• W2093148933 abstract "The alpha subunit of Eukaryotic Initiation Factor 2 (eIF2α) is a key translation regulator that plays an important role in cellular stress responses, which including virus infection. To investigate whether WSSV infection can activate the PERK-eIF2α pathway, the eIF2α in shrimp Litopenaeus vannamei, designed as LveIF2α, was analyzed. The LveIF2α, a 332-amino acid polypeptide, shares a high degree of similarity with eIF2α from other species, having two eIF2α protein signatures at the 13-88 aa and 192-243 aa. The WSSV challenge experiment showed that the protein level of the total LveIF2α was decreased after infection, while the phosphorylation of LveIF2α has no significant change, which indicated that the phosphorylation ratio of LveIF2α was increased after infection. Furthermore, inhibitor treatment led to a significant decrease of WSSV loads. Moreover, the Binding immunoglobulin protein (BiP), an endoplasmic reticulum (ER) stress sensor, and PERK were also investigated during virus infection and it was shown that they were both up-regulated. Taken together, these results suggested that WSSV infection can induce ER stress and activated the unfolded protein response (UPR), and the PERK-eIF2α pathway is important for innate immune during WSSV infection in shrimp." @default.
• W2093148933 created "2016-06-24" @default.
• W2093148933 creator A5022617539 @default.
• W2093148933 creator A5061947719 @default.
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• W2093148933 date "2014-10-01" @default.
• W2093148933 modified "2023-09-24" @default.
• W2093148933 title "eIF2α of Litopenaeus vannamei involved in shrimp immune response to WSSV infection" @default.
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• W2093148933 doi "https://doi.org/10.1016/j.fsi.2014.08.016" @default.
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