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• W2093152743 abstract "The use of intensity-modulated radiation therapy (IMRT) is now widely advocated for the treatment of prostate cancer to increase the therapeutic ratio. IMRT can be delivered with a multileaf collimator (MLC) either as conventional two phase IMRT or as simultaneous integrated boost (SIB). This report aims to compare the volumetric and dosimetric parameters between the two methods of IMRT delivery. Objectives: To compare conformality index and homogeneity index between conventional and SIB IMRT plans; To compare the mean dose to the rectum, bladder and femur head; To compare beam-on time (MU or monitor units). Ten patients of high risk carcinoma prostate who were treated by IMRT were included in the study. Patients were immobilized in a thermoplastic mould and simulation was done using spiral CT scan with 5mm thick slices. Images were transferred to treatment planning system and contouring was done according to RTOG guidelines. For each patient, IMRT planning was done by two methods, conventional planning with dose prescription of 45 Gy to PTV45 which includes primary and elective nodes (1.8 Gy/fraction, 25 fractions) and 27 Gy boost to primary (1.8 Gy/fraction, 15 fractions) and SIB IMRT to deliver 45 Gy to PTV 45 (1.8 Gy/fraction, 25 fractions), 60.75 Gy to PTVboost (2.43Gy/fraction, 25 fractions). Dose plans were evaluated in terms of dose to organs at risk, conformality index and homogeneity index using the RTOG criteria and SALT criteria. Beam-on time(MUs) was evaluated. Data analysis was done using Windows SPSS software version 20 for Statistical analysis. There was no significant difference between the SIB IMRT and conventional IMRT plans for PTV 45 and PTV boost regarding RTOG conformality index (p = 0.052,0.256 respectively), Lomax and Scheib conformality index (p = 0.056,0.115 respectively), homogeneity index for PTV boost (p = 0.107) and mean rectal dose (p = 0.10). There was a significant difference between the two plans in homogeneity index for PTV45 (p = 0.0001), Beam-on time (MU) (p = 0.0001), mean bladder dose (p = 0.006), mean dose to left femur head (p = 0.001) and right femur head (p = 0.0001). Conventional IMRT and SIB IMRT methods of delivery showed similar volumetric parameters. SIB IMRT method has an advantage of shorter duration of treatment (by three weeks) with relatively lower doses to the femur head and bladder and lower beam-on time (87% less). SIB IMRT may have radiobiological advantage due to low α/ß ratio of carcinoma prostate." @default.
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• W2093152743 date "2012-11-01" @default.
• W2093152743 modified "2023-10-05" @default.
• W2093152743 title "Conventional 2 Phase Versus Simultaneous Integrated Boost Methods of Intensity Modulated Radiation Therapy in Carcinoma of the Prostate—Analysis of Volumetric and Dosimetric Parameters" @default.
• W2093152743 doi "https://doi.org/10.1016/j.ijrobp.2012.07.2109" @default.
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